Vrk1 MGI Mouse Gene Detail - MGI:1261847 - vaccinia related kinase 1

Symbol

Vrk1
Name

vaccinia related kinase 1
Synonyms

51PK

Feature Type

protein coding gene
IDs

MGI:1261847
NCBI Gene: 22367
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr12:105976487-106043685 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 56.37 cM, cytoband F1
Mapping Data

2 experiments

SNPs within 2kb

2002 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1261847	protein coding gene	Chr12:105976398-106044578 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0020097	protein coding gene	Chr12:107923883-108001585 (+)
A/J	MGP_AJ_G0020051	protein coding gene	Chr12:103888068-103957323 (+)
AKR/J	MGP_AKRJ_G0020027	protein coding gene	Chr12:106901923-106977342 (+)
BALB/cJ	MGP_BALBcJ_G0020037	protein coding gene	Chr12:104313775-104381385 (+)
C3H/HeJ	MGP_C3HHeJ_G0019839	protein coding gene	Chr12:107337030-107409320 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020482	protein coding gene	Chr12:111263092-111335483 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018094	protein coding gene	Chr12:100470719-100544457 (+)
CAST/EiJ	MGP_CASTEiJ_G0019381	protein coding gene	Chr12:102150449-102225956 (+)
CBA/J	MGP_CBAJ_G0019806	protein coding gene	Chr12:115690224-115762553 (+)
DBA/2J	MGP_DBA2J_G0019923	protein coding gene	Chr12:103411344-103480065 (+)
FVB/NJ	MGP_FVBNJ_G0019908	protein coding gene	Chr12:102194335-102265824 (+)
LP/J	MGP_LPJ_G0019998	protein coding gene	Chr12:107815260-107887188 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019946	protein coding gene	Chr12:119049528-119120512 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020511	protein coding gene	Chr12:106310919-106381802 (+)
PWK/PhJ	MGP_PWKPhJ_G0019140	protein coding gene	Chr12:97998120-98070756 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018944	protein coding gene	Chr12:100526420-100602870 (+)
WSB/EiJ	MGP_WSBEiJ_G0019438	protein coding gene	Chr12:107260749-107330314 (+)

Human Ortholog

VRK1, VRK serine/threonine kinase 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

VRK1, VRK serine/threonine kinase 1
Synonyms

HMNR10, PCH1, PCH1A
Links

HGNC:12718

NCBI Gene ID: 7443

neXtProt AC: NX_Q99986

UniProt: Q99986
Chr Location

14q32.2; chr14:96797304-96954846 (+) GRCh38

MGI Vertebrate Homology

Vrk1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: VRK1
Gene Tree

Vrk1

Diseases

2 with human VRK1 associations

				Human Disease	Mouse Models
				autosomal recessive distal hereditary motor neuronopathy 10 IDs autosomal recessive distal hereditary motor neuronopathy 10 DOID:0081429 OMIM:620542
				pontocerebellar hypoplasia type 1A IDs pontocerebellar hypoplasia type 1A DOID:0060265 OMIM:607596 ORDO:2254

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

30 phenotypes from 3 alleles in 4 genetic backgrounds
8 phenotypes from multigenic genotypes
21 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

46
Chemically induced (other)

1
Endonuclease-mediated

6
Gene trapped

39
Genomic Mutations

1 involving Vrk1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

42 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Males homozygous for a hypomorphic gene trap show progressive loss of proliferating spermatogonia, lack of meiotic cells and mature sperm and early onset sterility, whereas females show complete sterility due to defects in meiotic progression during oogenesis and failure of oocyte fertilization.

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All GO Annotations

70
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

744
Tissues

38
cDNA Data

72
Literature Summary

3

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase vrk1

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All Sequences

109
RefSeq

56
UniProt

6
CCDS

CCDS26157.1, CCDS26158.1, CCDS36551.1

Ensembl

ENSMUSG00000021115 (Evidence)
NCBI Gene

22367

			Length	Strain/Species	Flank
genomic	ENSMUSG00000021115	Ensembl Gene Model \| MGI Sequence Detail	67199	C57BL/6J	± kb
transcript	ENSMUST00000021539	Ensembl \| MGI Sequence Detail	1742	Not Applicable
polypeptide	ENSMUSP00000021539	Ensembl \| MGI Sequence Detail	440	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000017349 serine/threonine-protein kinase VRK1

(term hierarchy)
EC

2.7.11.1
InterPro Domains

IPR050235 Casein Kinase 1 Ser/Thr Protein Kinase

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR008271 Serine/threonine-protein kinase, active site

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All nucleic 73

cDNA 72

Primer pair 1

Microarray probesets 4

Summaries

All 56

Developmental Gene Expression 3

Gene Ontology 11

Phenotypes 21
Earliest

J:46795 Zelko I, et al., Molecular cloning and characterization of a novel nuclear protein kinase in mice. Arch Biochem Biophys. 1998 Apr 1;352(1):31-6
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Vrk1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr114928	Chr12:105976463-105976484 (+)	-13 bp
Tssr114929	Chr12:105976534-105976598 (+)	79 bp
Tssr114930	Chr12:105996962-105996984 (+)	20,486 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24