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Cisd1 Gene Detail
Summary
  • Symbol
    Cisd1
  • Name
    CDGSH iron sulfur domain 1
  • Synonyms
    D10Ertd214e, mitoNEET, Zcd1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1261855
    NCBI Gene: 52637
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:71166324-71180679 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 36.88 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    395 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1261855
 protein coding gene Chr10:71166310-71180784 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017344
 protein coding gene Chr10:71323371-71339282 (-)
A/J MGP_AJ_G0017321
 protein coding gene Chr10:68868454-68883274 (-)
AKR/J MGP_AKRJ_G0017282
 protein coding gene Chr10:70758929-70778193 (-)
BALB/cJ MGP_BALBcJ_G0017281
 protein coding gene Chr10:69070027-69085027 (-)
C3H/HeJ MGP_C3HHeJ_G0017105
 protein coding gene Chr10:70762884-70777770 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017739
 protein coding gene Chr10:73858048-73874276 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015429
 protein coding gene Chr10:65439237-65453771 (-)
CAST/EiJ MGP_CASTEiJ_G0016675
 protein coding gene Chr10:70922858-70938227 (-)
CBA/J MGP_CBAJ_G0017077
 protein coding gene Chr10:76740644-76755231 (-)
DBA/2J MGP_DBA2J_G0017182
 protein coding gene Chr10:68224779-68239290 (-)
FVB/NJ MGP_FVBNJ_G0017175
 protein coding gene Chr10:67393399-67409085 (-)
LP/J MGP_LPJ_G0017255
 protein coding gene Chr10:71759807-71774266 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017203
 protein coding gene Chr10:78808039-78822996 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017778
 protein coding gene Chr10:70719260-70733882 (-)
PWK/PhJ MGP_PWKPhJ_G0016459
 protein coding gene Chr10:68079929-68095893 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016242
 protein coding gene Chr10:70089424-70103961 (-)
WSB/EiJ MGP_WSBEiJ_G0016739
 protein coding gene Chr10:70674426-70689217 (-)



Homology
more
  • Human Ortholog
    CISD1, CDGSH iron sulfur domain 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CISD1, CDGSH iron sulfur domain 1
  • Synonyms
    C10orf70, MDS029, mitoNEET, ZCD1
  • Links
    NCBI Gene ID: 55847
    neXtProt AC: NX_Q9NZ45
    UniProt: Q9NZ45

  • Chr Location
    10q21.1; chr10:58269162-58289586 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit reduced oxidative capacity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    24
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    860
  • Tissues
    33
  • cDNA Data
    123
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 52637 NCBI Gene Model | MGI Sequence Detail 14356 C57BL/6J ±  kb
    transcript NM_134007 RefSeq | MGI Sequence Detail 965 ZRU/MplStud  
    polypeptide Q91WS0 UniProt | EBI | MGI Sequence Detail 108 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000005501 CDGSH iron-sulfur domain-containing protein 1
      (term hierarchy)
    • EC
      2.6.1.3
    • InterPro Domains
      IPR045131 CDGSH iron-sulfur domain-containing protein 1/2
      IPR018967 Iron-binding zinc finger, CDGSH type
      IPR019610 Iron sulphur domain-containing, mitoNEET, N-terminal
      IPR042216 MitoNEET, CDGSH iron-sulfur domain
    • GlyGen
      Q91WS0 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 125
      cDNA 123
      Primer pair 2

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:2143766, MGI:2144588
    References
    more
    • Summaries
      All 60
      Developmental Gene Expression 2
      Gene Ontology 8
      Phenotypes 24
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory