Pibf1 MGI Mouse Gene Detail - MGI:1261910 - progesterone immunomodulatory binding factor 1

Symbol

Pibf1
Name

progesterone immunomodulatory binding factor 1
Synonyms

1700017E21Rik, 4930513H15Rik, 4933438D16Rik, 4933439E17Rik, D14Ertd581e

Feature Type

protein coding gene
IDs

MGI:1261910
NCBI Gene: 52023
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr14:99336860-99491929 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 49.27 cM, cytoband E2.1
Mapping Data

4 experiments

SNPs within 2kb

4268 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1261910	protein coding gene	Chr14:99336860-99492335 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0021617	protein coding gene	Chr14:95371800-95533047 (+)
A/J	MGP_AJ_G0021575	protein coding gene	Chr14:92334379-92491043 (+)
AKR/J	MGP_AKRJ_G0021551	protein coding gene	Chr14:95048816-95214154 (+)
BALB/cJ	MGP_BALBcJ_G0021581	protein coding gene	Chr14:92666896-92829311 (+)
C3H/HeJ	MGP_C3HHeJ_G0021359	protein coding gene	Chr14:94935802-95099047 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0022021	protein coding gene	Chr14:99265610-99436224 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019561	protein coding gene	Chr14:89383476-89543010 (+)
CAST/EiJ	MGP_CASTEiJ_G0020876	protein coding gene	Chr14:92227318-92390909 (+)
CBA/J	MGP_CBAJ_G0021327	protein coding gene	Chr14:102940990-103119911 (+)
DBA/2J	MGP_DBA2J_G0021451	protein coding gene	Chr14:91828079-91984161 (+)
FVB/NJ	MGP_FVBNJ_G0021428	protein coding gene	Chr14:90865778-91025543 (+)
LP/J	MGP_LPJ_G0021519	protein coding gene	Chr14:96176615-96335586 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021455	protein coding gene	Chr14:105663247-105837091 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022044	protein coding gene	Chr14:94558053-94724762 (+)
PWK/PhJ	MGP_PWKPhJ_G0020619	protein coding gene	Chr14:88808735-88969098 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0020457	protein coding gene	Chr14:90529706-90698644 (+)
WSB/EiJ	MGP_WSBEiJ_G0020929	protein coding gene	Chr14:95160546-95326544 (+)

Human Ortholog

PIBF1, progesterone immunomodulatory binding factor 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PIBF1, progesterone immunomodulatory binding factor 1
Synonyms

C13orf24, CEP90, JBTS33, PIBF
Links

HGNC:23352

NCBI Gene ID: 10464

neXtProt AC: NX_Q8WXW3

UniProt: Q8WXW3
Chr Location

13q21.33-q22.1; chr13:72782133-73016461 (+) GRCh38

MGI Vertebrate Homology

Pibf1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PIBF1
Gene Tree

Pibf1

Diseases

1 with human PIBF1 associations

				Human Disease	Mouse Models
				Joubert syndrome 33 IDs Joubert syndrome 33 DOID:0080279 OMIM:617767

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

16 phenotypes from 1 allele in 2 genetic backgrounds
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

19
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

13
Targeted

2
Genomic Mutations

1 involving Pibf1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

53 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele show pericardial edema, abnormal heart looping, absence of embryonic cilia, and complete embryonic lethality prior to organogenesis.

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All GO Annotations

19
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

761
Tissues

48
cDNA Data

29
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase pibf1

ZFIN pibf1

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All Sequences

68
RefSeq

13
UniProt

6
CCDS

CCDS36997.1

Ensembl

ENSMUSG00000022064 (Evidence)
NCBI Gene

52023

			Length	Strain/Species	Flank
genomic	ENSMUSG00000022064	Ensembl Gene Model \| MGI Sequence Detail	155070	C57BL/6J	± kb
transcript	ENSMUST00000022650	Ensembl \| MGI Sequence Detail	2797	Not Applicable
polypeptide	ENSMUSP00000022650	Ensembl \| MGI Sequence Detail	756	Not Applicable

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UniProt

6 Sequences
InterPro Domains

IPR026205 Progesterone-induced-blocking factor 1

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All nucleic 30

cDNA 29

Primer pair 1

Microarray probesets 5

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MGI:1918542, MGI:1918565, MGI:1922765, MGI:1923071

Summaries

All 45

Developmental Gene Expression 4

Gene Ontology 2

Phenotypes 15
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Pibf1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr126874	Chr14:99336904-99336912 (+)	48 bp
Tssr126875	Chr14:99337312-99337398 (+)	495 bp
Tssr126876	Chr14:99337424-99337448 (+)	576 bp
Tssr126877	Chr14:99337452-99337464 (+)	598 bp
Tssr4505	Chr14:99385303-99385304 (+)	48,444 bp
Tssr126878	Chr14:99439043-99439048 (+)	102,186 bp
Tssr126879	Chr14:99463601-99463610 (+)	126,746 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24