Dnaja1 MGI Mouse Gene Detail - MGI:1270129 - DnaJ heat shock protein family (Hsp40) member A1

Symbol

Dnaja1
Name

DnaJ heat shock protein family (Hsp40) member A1
Synonyms

Hsj2, Nedd7

Feature Type

protein coding gene
IDs

MGI:1270129
NCBI Gene: 15502
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr4:40722468-40734965 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 20.46 cM
Mapping Data

3 experiments

SNPs within 2kb

300 from dbSNP Build 142
Strain Annotations

18
PCR

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1270129	protein coding gene	Chr4:40722150-40737149 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0028146	protein coding gene	Chr4:38610760-38625943 (+)
A/J	MGP_AJ_G0028104	protein coding gene	Chr4:37163741-37178859 (+)
AKR/J	MGP_AKRJ_G0028067	protein coding gene	Chr4:38098312-38118450 (+)
BALB/cJ	MGP_BALBcJ_G0028116	protein coding gene	Chr4:37487337-37503776 (+)
C3H/HeJ	MGP_C3HHeJ_G0027844	protein coding gene	Chr4:38636362-38653776 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0028557	protein coding gene	Chr4:40045937-40061732 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025898	protein coding gene	Chr4:34819388-34834293 (+)
CAST/EiJ	MGP_CASTEiJ_G0027300	protein coding gene	Chr4:38302806-38318876 (+)
CBA/J	MGP_CBAJ_G0027816	protein coding gene	Chr4:41392854-41408248 (+)
DBA/2J	MGP_DBA2J_G0027960	protein coding gene	Chr4:37080807-37097860 (+)
FVB/NJ	MGP_FVBNJ_G0027927	protein coding gene	Chr4:36416438-36431949 (+)
LP/J	MGP_LPJ_G0028068	protein coding gene	Chr4:38677415-38693200 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027960	protein coding gene	Chr4:44745584-44758641 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028616	protein coding gene	Chr4:38212987-38228753 (+)
PWK/PhJ	MGP_PWKPhJ_G0027019	protein coding gene	Chr4:37077880-37094368 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0026847	protein coding gene	Chr4:37926995-37939598 (+)
WSB/EiJ	MGP_WSBEiJ_G0027376	protein coding gene	Chr4:38162275-38178607 (+)

Human Ortholog

DNAJA1, DnaJ heat shock protein family (Hsp40) member A1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DNAJA1, DnaJ heat shock protein family (Hsp40) member A1
Synonyms

DJ-2, DjA1, hDJ-2, HDJ2, HSDJ, HSJ-2, HSJ2, HSPF4, NEDD7
Links

HGNC:5229

NCBI Gene ID: 3301

neXtProt AC: NX_P31689

UniProt: P31689
Chr Location

9p21.1; chr9:33025273-33039907 (+) GRCh38

MGI Vertebrate Homology

Dnaja1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: DNAJA1
Gene Tree

Dnaja1

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Phenotype Summary

16 phenotypes from 2 alleles in 2 genetic backgrounds
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

38
Chemically and radiation induced

1
Endonuclease-mediated

2
Gene trapped

32
Targeted

3
Genomic Mutations

1 involving Dnaja1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

21 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Male mice homozygous for a knock-out allele exhibit decreased postnatal growth and reduced fertility with severe defects in late stages of spermatogenesis that involve aberrant androgen receptor signaling in Sertoli cells and disruption of Sertoli-germ cell adherens junctions.

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All GO Annotations

55
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

801
Tissues

76
cDNA Data

19
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase dnaja1

ZFIN dnaja1

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All Sequences

71
RefSeq

6
UniProt

6
CCDS

CCDS18049.1

Ensembl

ENSMUSG00000028410 (Evidence)
NCBI Gene

15502

			Length	Strain/Species	Flank
genomic	15502	NCBI Gene Model \| MGI Sequence Detail	12498	C57BL/6J	± kb
transcript	NM_001164671	RefSeq \| MGI Sequence Detail	3459	C57BL/6
polypeptide	P63037	UniProt \| EBI \| MGI Sequence Detail	397	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000006570 DnaJ homolog subfamily A member 1

(term hierarchy)
InterPro Domains

IPR012724 Chaperone DnaJ

IPR002939 Chaperone DnaJ, C-terminal

IPR036869 Chaperone J-domain superfamily

IPR001623 DnaJ domain

IPR018253 DnaJ domain, conserved site

IPR044713 DnaJ homolog subfamily A member 1/2-like

IPR001305 Heat shock protein DnaJ, cysteine-rich domain

IPR036410 Heat shock protein DnaJ, cysteine-rich domain superfamily

IPR008971 HSP40/DnaJ peptide-binding
GlyGen

P63037 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)

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All nucleic 22

cDNA 19

Primer pair 2

Other 1

Microarray probesets 5

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MGD-MRK-12813, MGI:97300

Summaries

All 53

Developmental Gene Expression 4

Gene Ontology 11

Phenotypes 15
Earliest

J:1344 Kumar S, et al., Identification of a set of genes with developmentally down-regulated expression in the mouse brain. Biochem Biophys Res Commun. 1992 Jun 30;185(3):1155-61
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Dnaja1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr36809	Chr4:40722461-40722512 (+)	19 bp
Tssr36810	Chr4:40722525-40722547 (+)	68 bp
Tssr36812	Chr4:40723017-40723031 (+)	556 bp
Tssr36813	Chr4:40723084-40723104 (+)	626 bp
Tssr36814	Chr4:40726825-40726831 (+)	4,360 bp
Tssr36815	Chr4:40727101-40727105 (+)	4,635 bp
Tssr36816	Chr4:40728974-40728977 (+)	6,508 bp
Tssr36817	Chr4:40731276-40731302 (+)	8,821 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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