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Fam3b Gene Detail
Summary
  • Symbol
    Fam3b
  • Name
    FAM3 metabolism regulating signaling molecule B
  • Synonyms
    9030624C24Rik, D16Jhu19e, ORF9, Pander
  • Feature Type
    protein coding gene
  • IDs
    MGI:1270150
    NCBI Gene: 52793
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:97272165-97306136 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 57.47 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    707 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1270150
 protein coding gene Chr16:97272165-97316016 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023091
 protein coding gene Chr16:98903607-98942147 (-)
A/J MGP_AJ_G0023059
 protein coding gene Chr16:94239567-94276378 (-)
AKR/J MGP_AKRJ_G0023029
 protein coding gene Chr16:97133832-97168162 (-)
BALB/cJ MGP_BALBcJ_G0023061
 protein coding gene Chr16:94788796-94822880 (-)
C3H/HeJ MGP_C3HHeJ_G0022822
 protein coding gene Chr16:97662306-97699519 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023508
 protein coding gene Chr16:102001517-102033489 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021010
 protein coding gene Chr16:92071826-92103306 (-)
CAST/EiJ MGP_CASTEiJ_G0022342
 protein coding gene Chr16:98473173-98506201 (-)
CBA/J MGP_CBAJ_G0022791
 protein coding gene Chr16:106433912-106467451 (-)
DBA/2J MGP_DBA2J_G0022925
 protein coding gene Chr16:94101171-94134533 (-)
FVB/NJ MGP_FVBNJ_G0022899
 protein coding gene Chr16:93264217-93296486 (-)
LP/J MGP_LPJ_G0022995
 protein coding gene Chr16:98556209-98591367 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022920
 protein coding gene Chr16:110577087-110613370 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023526
 protein coding gene Chr16:97681463-97719280 (-)
PWK/PhJ MGP_PWKPhJ_G0022086
 protein coding gene Chr16:94417385-94449351 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021916
 protein coding gene Chr16:97189235-97224002 (-)
WSB/EiJ MGP_WSBEiJ_G0022392
 protein coding gene Chr16:97960314-97995427 (-)



Homology
more
  • Human Ortholog
    FAM3B, FAM3 metabolism regulating signaling molecule B
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FAM3B, FAM3 metabolism regulating signaling molecule B
  • Synonyms
    2-21, C21orf11, C21orf76, ORF9, PANDER, PRED44
  • Links
    NCBI Gene ID: 54097
    neXtProt AC: NX_P58499
    UniProt: P58499

  • Chr Location
    21q22.3; chr21:41304212-41357727 (+)  GRCh38
Human Diseases
less
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 2 alleles in 2 genetic backgrounds
    47 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a deletion of this gene display elevated blood glucose in glucose tolerance tests and elevated blood insulin after glucose injection, probably due to impaired insulin clearance.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    773
  • Tissues
    66
  • cDNA Data
    7
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 52793 NCBI Gene Model | MGI Sequence Detail 33972 C57BL/6J ±  kb
    transcript NM_020622 RefSeq | MGI Sequence Detail 972 Not Specified  
    polypeptide Q9D309 UniProt | EBI | MGI Sequence Detail 235 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 9
      cDNA 7
      Primer pair 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1923006
    References
    more
    • Summaries
      All 81
      Developmental Gene Expression 2
      Diseases 3
      Gene Ontology 6
      Phenotypes 47
    • Earliest
      J:50129 Cabin DE, et al., Physical and comparative mapping of distal mouse chromosome 16. 5 p5. Genome Res. 1998 Sep;8(9):940-50
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory