Septin4 MGI Mouse Gene Detail - MGI:1270156

Symbol

Septin4
Name

septin 4
Synonyms

ARTS, Bh5, cell division control-related protein 2b, Gm11492, Pnutl2, Sept4, septin H5

Feature Type

protein coding gene
IDs

MGI:1270156
NCBI Gene: 18952
Alliance

gene page
Transcription Start Sites

13 TSS

Sequence Map

Chr11:87457515-87481365 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 52.14 cM
Mapping Data

1 experiment

SNPs within 2kb

93 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1270156	protein coding gene	Chr11:87457479-87481365 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018906	protein coding gene	Chr11:89195160-89218258 (+)
A/J	MGP_AJ_G0018873	protein coding gene	Chr11:85752340-85773924 (+)
AKR/J	MGP_AKRJ_G0018843	protein coding gene	Chr11:88321583-88343187 (+)
BALB/cJ	MGP_BALBcJ_G0018846	protein coding gene	Chr11:86148966-86171600 (+)
C3H/HeJ	MGP_C3HHeJ_G0018660	protein coding gene	Chr11:88357201-88380668 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019298	protein coding gene	Chr11:91896981-91922965 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016931	protein coding gene	Chr11:82781984-82803554 (+)
CAST/EiJ	MGP_CASTEiJ_G0018215	protein coding gene	Chr11:89048900-89072466 (+)
CBA/J	MGP_CBAJ_G0018631	protein coding gene	Chr11:95751300-95780587 (+)
DBA/2J	MGP_DBA2J_G0018739	protein coding gene	Chr11:85306419-85328344 (+)
FVB/NJ	MGP_FVBNJ_G0018728	protein coding gene	Chr11:84813397-84835870 (+)
LP/J	MGP_LPJ_G0018809	protein coding gene	Chr11:89686998-89708747 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018755	protein coding gene	Chr11:95813783-95836359 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019338	protein coding gene	Chr11:88559581-88581938 (+)
PWK/PhJ	MGP_PWKPhJ_G0017985	protein coding gene	Chr11:86152725-86175499 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017778	protein coding gene	Chr11:88122206-88146133 (+)
WSB/EiJ	MGP_WSBEiJ_G0018266	protein coding gene	Chr11:88436093-88460100 (+)

Human Ortholog

SEPTIN4, septin 4

Vertebrate Orthologs

5

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SEPTIN4, septin 4
Synonyms

ARTS, BRADEION, C17orf47, CE5B3, H5, hCDCREL-2, hucep-7, MART, PNUTL2, SEP4, SEPT4, Septin-4
Links

HGNC:9165

NCBI Gene ID: 5414

neXtProt AC: NX_O43236

UniProt: O43236
Chr Location

17q22; chr17:58520250-58544368 (-) GRCh38

MGI Vertebrate Homology

Septin4 stringent orthology
1 human;1 mouse;1 rat;3 zebrafish
HCOP

vertebrate homology predictions: SEPTIN4
Protein SuperFamily

Septin
Gene Tree

Septin4

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Phenotype Summary

15 phenotypes from 2 alleles in 2 genetic backgrounds
21 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Chemically induced (other)

1
Endonuclease-mediated

2
Targeted

4
Transgenic

1
Genomic Mutations

2 involving Septin4
Incidental Mutations

Mutagenetix , Mutagenetix , APF , APF , CvDC
Find Mice (IMSR)

42 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null males are sterile and have immotile and structurally defective sperm that is bent and lacks the annulus.

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All GO Annotations

57
GO References

17

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

821
Tissues

66
cDNA Data

58
Literature Summary

9

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase septin4

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All Sequences

115
RefSeq

47
UniProt

4
CCDS

CCDS25213.1, CCDS70275.1, CCDS70276.1, CCDS70277.1, CCDS88214.1

Ensembl

ENSMUSG00000020486 (Evidence)
NCBI Gene

18952

			Length	Strain/Species	Flank
genomic	18952	NCBI Gene Model \| MGI Sequence Detail	23851	C57BL/6J	± kb
transcript	NM_001424196	RefSeq \| MGI Sequence Detail	3193	C57BL/6
polypeptide	P28661	UniProt \| EBI \| MGI Sequence Detail	478	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000014656 septin-4

(term hierarchy)

PR:000034503 uncharacterized protein C17orf47 homolog

(term hierarchy)
InterPro Domains

IPR027417 P-loop containing nucleoside triphosphate hydrolase

IPR027979 Protein of unknown function DUF4655

IPR016491 Septin

IPR030379 Septin-type guanine nucleotide-binding (G) domain
GlyGen

P28661 2 sites, 2 N-linked glycans (2 sites)

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All nucleic 60

cDNA 59

Primer pair 1

Microarray probesets 4

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MGI:3651136, MGI:6368833

Summaries

All 67

Developmental Gene Expression 9

Gene Ontology 17

Phenotypes 21
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:269496 Koren E, et al., ARTS mediates apoptosis and regeneration of the intestinal stem cell niche. Nat Commun. 2018 Nov 2;9(1):4582

TSS for Septin4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr103928	Chr11:87457482-87457487 (+)	-30 bp
Tssr103929	Chr11:87457496-87457499 (+)	-17 bp
Tssr103930	Chr11:87457506-87457536 (+)	6 bp
Tssr103931	Chr11:87457544-87457558 (+)	36 bp
Tssr103932	Chr11:87469210-87469296 (+)	11,738 bp
Tssr103933	Chr11:87469303-87469318 (+)	11,796 bp
Tssr103934	Chr11:87469324-87469326 (+)	11,810 bp
Tssr103935	Chr11:87471871-87471893 (+)	14,367 bp
Tssr103936	Chr11:87471932-87471951 (+)	14,427 bp
Tssr103937	Chr11:87471972-87471979 (+)	14,461 bp
Tssr103938	Chr11:87473027-87473041 (+)	15,519 bp
Tssr103939	Chr11:87473059-87473070 (+)	15,550 bp
Tssr103940	Chr11:87474763-87474777 (+)	17,255 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24