Eif4ebp3 MGI Mouse Gene Detail - MGI:1270847 - eukaryotic translation initiation factor 4E binding protein 3

Symbol

Eif4ebp3
Name

eukaryotic translation initiation factor 4E binding protein 3
Synonyms

4E-BP3, MGC:74395

Feature Type

protein coding gene
IDs

MGI:1270847
NCBI Gene: 108112
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr18:36797113-36798970 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 18, 19.46 cM
Mapping Data

1 experiment

SNPs within 2kb

101 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1270847	protein coding gene	Chr18:36797113-36799377 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0024281	protein coding gene	Chr18:35072396-35074253 (+)
A/J	MGP_AJ_G0024247	protein coding gene	Chr18:33834710-33836567 (+)
AKR/J	MGP_AKRJ_G0024215	protein coding gene	Chr18:34782349-34784206 (+)
BALB/cJ	MGP_BALBcJ_G0024247	protein coding gene	Chr18:33887067-33888924 (+)
C3H/HeJ	MGP_C3HHeJ_G0024014	protein coding gene	Chr18:34847737-34849594 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0024688	protein coding gene	Chr18:36302199-36304056 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022128	protein coding gene	Chr18:33929339-33931213 (+)
CAST/EiJ	MGP_CASTEiJ_G0023489	protein coding gene	Chr18:34858132-34859989 (+)
CBA/J	MGP_CBAJ_G0023982	protein coding gene	Chr18:37377519-37379376 (+)
DBA/2J	MGP_DBA2J_G0024114	protein coding gene	Chr18:33457741-33459598 (+)
FVB/NJ	MGP_FVBNJ_G0024081	protein coding gene	Chr18:33164339-33166196 (+)
LP/J	MGP_LPJ_G0024196	protein coding gene	Chr18:35101368-35103225 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024109	protein coding gene	Chr18:38592527-38594384 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024737	protein coding gene	Chr18:34656035-34657892 (+)
PWK/PhJ	MGP_PWKPhJ_G0023233	protein coding gene	Chr18:33710616-33712473 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023040	protein coding gene	Chr18:34901268-34903119 (+)
WSB/EiJ	MGP_WSBEiJ_G0023552	protein coding gene	Chr18:34576483-34578340 (+)

Human Ortholog

EIF4EBP3, eukaryotic translation initiation factor 4E binding protein 3

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

EIF4EBP3, eukaryotic translation initiation factor 4E binding protein 3
Synonyms

4E-BP3, 4EBP3
Links

HGNC:3290

NCBI Gene ID: 8637

neXtProt AC: NX_O60516

UniProt: O60516
Chr Location

5q31.3; chr5:140547662-140549576 (+) GRCh38

MGI Vertebrate Homology

Eif4ebp3 stringent orthology
1 human;1 mouse;2 zebrafish
HCOP

vertebrate homology predictions: EIF4EBP3
Gene Tree

Eif4ebp3

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

3
Endonuclease-mediated

1
Targeted

2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

5 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

7
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

719
Tissues

9
cDNA Data

36
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN eif4ebp3

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All Sequences

30
RefSeq

2
UniProt

1
CCDS

CCDS29155.1

Ensembl

ENSMUSG00000090264 (Evidence)
NCBI Gene

108112

			Length	Strain/Species	Flank
genomic	ENSMUSG00000090264	Ensembl Gene Model \| MGI Sequence Detail	1858	C57BL/6J	± kb
transcript	ENSMUST00000036765	Ensembl \| MGI Sequence Detail	744	Not Applicable
polypeptide	ENSMUSP00000039298	Ensembl \| MGI Sequence Detail	101	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000006996 eukaryotic translation initiation factor 4E-binding protein 3

(term hierarchy)
InterPro Domains

IPR008606 Eukaryotic translation initiation factor 4E binding

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All nucleic 36

cDNA 36

Microarray probesets 1

Summaries

All 31

Developmental Gene Expression 1

Gene Ontology 4

Phenotypes 10
Earliest

J:47951 Poulin F, et al., 4E-BP3, a new member of the eukaryotic initiation factor 4E-binding protein family. J Biol Chem. 1998 May 29;273(22):14002-7
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Eif4ebp3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr150647	Chr18:36797159-36797177 (+)	55 bp
Tssr150648	Chr18:36797185-36797210 (+)	85 bp
Tssr150649	Chr18:36798374-36798400 (+)	1,274 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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