Rps6kb1 MGI Mouse Gene Detail - MGI:1270849 - ribosomal protein S6 kinase, polypeptide 1

Symbol

Rps6kb1
Name

ribosomal protein S6 kinase, polypeptide 1
Synonyms

2610318I15Rik, p70/85s6k, p70s6k, p70S6K1, S6K1

Feature Type

protein coding gene
IDs

MGI:1270849
NCBI Gene: 72508
Alliance

gene page
Transcription Start Sites

1 TSS
Candidate for QTL

1 QTL

Sequence Map

Chr11:86389697-86435631 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 51.82 cM
Mapping Data

3 experiments

SNPs within 2kb

757 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1270849	protein coding gene	Chr11:86389695-86435711 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0018890	protein coding gene	Chr11:88057530-88106445 (-)
A/J	MGP_AJ_G0018857	protein coding gene	Chr11:84672140-84720880 (-)
AKR/J	MGP_AKRJ_G0018827	protein coding gene	Chr11:87205451-87253511 (-)
BALB/cJ	MGP_BALBcJ_G0018830	protein coding gene	Chr11:85059734-85105753 (-)
C3H/HeJ	MGP_C3HHeJ_G0018644	protein coding gene	Chr11:87234227-87282876 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0019282	protein coding gene	Chr11:90724223-90774227 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016915	protein coding gene	Chr11:81702592-81743986 (-)
CAST/EiJ	MGP_CASTEiJ_G0018199	protein coding gene	Chr11:87916085-87967564 (-)
CBA/J	MGP_CBAJ_G0018615	protein coding gene	Chr11:94539090-94592973 (-)
DBA/2J	MGP_DBA2J_G0018723	protein coding gene	Chr11:84244307-84292165 (-)
FVB/NJ	MGP_FVBNJ_G0018712	protein coding gene	Chr11:83746877-83794391 (-)
LP/J	MGP_LPJ_G0018793	protein coding gene	Chr11:88549322-88598316 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018739	protein coding gene	Chr11:94647579-94695597 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019322	protein coding gene	Chr11:87451447-87498621 (-)
PWK/PhJ	MGP_PWKPhJ_G0017968	protein coding gene	Chr11:85039288-85086270 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0017760	protein coding gene	Chr11:87006292-87053776 (-)
WSB/EiJ	MGP_WSBEiJ_G0018250	protein coding gene	Chr11:87324149-87372662 (-)

Human Ortholog

RPS6KB1, ribosomal protein S6 kinase B1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RPS6KB1, ribosomal protein S6 kinase B1
Synonyms

p70-alpha, p70-S6K, p70 S6KA, p70(S6K)-alpha, PS6K, S6K, S6K1, S6K-beta-1, STK14A
Links

HGNC:10436

NCBI Gene ID: 6198

neXtProt AC: NX_P23443

UniProt: P23443
Chr Location

17q23.1; chr17:59893046-59950574 (+) GRCh38

MGI Vertebrate Homology

Rps6kb1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: RPS6KB1
Protein SuperFamily

Ribsml_S6_kin_1
Gene Tree

Rps6kb1

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Phenotype Summary

25 phenotypes from 2 alleles in 4 genetic backgrounds
34 phenotypes from multigenic genotypes
1 images
75 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

32
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

22
Targeted

7
Genomic Mutations

2 involving Rps6kb1
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

55 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygotes for a targeted null mutation exhibit reduced prenatal growth, glucose intolerance, and hypoinsulinemia associated with diminished pancreatic beta cell size.

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All GO Annotations

111
GO References

21

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

909
Tissues

48
cDNA Data

25
Literature Summary

75

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rps6kb1

ZFIN rps6kb1a, rps6kb1b

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All Sequences

100
RefSeq

33
UniProt

6
CCDS

CCDS25201.1, CCDS48875.1

Ensembl

ENSMUSG00000020516 (Evidence)
NCBI Gene

72508

			Length	Strain/Species	Flank
genomic	ENSMUSG00000020516	Ensembl Gene Model \| MGI Sequence Detail	45935	C57BL/6J	± kb
transcript	ENSMUST00000154617	Ensembl \| MGI Sequence Detail	5531	Not Applicable
polypeptide	ENSMUSP00000119715	Ensembl \| MGI Sequence Detail	525	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000000123 ribosomal protein S6 kinase beta-1

(term hierarchy)
EC

2.7.11.1
InterPro Domains

IPR000961 AGC-kinase, C-terminal

IPR017441 Protein kinase, ATP binding site

IPR017892 Protein kinase, C-terminal

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR016238 Ribosomal protein S6 kinase

IPR008271 Serine/threonine-protein kinase, active site
GlyGen

Q8BSK8 2 sites, 1 O-linked glycan (2 sites)

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All nucleic 30

Genomic 1

cDNA 28

Primer pair 1

Microarray probesets 10

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MGI:1919758, MGI:2144050, MGI:2144103, MGI:2144107

Summaries

All 251

Developmental Gene Expression 75

Gene Ontology 21

Phenotypes 75
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:354208 Dong MZ, et al., Protein phosphatase 4 maintains the survival of primordial follicles by regulating autophagy in oocytes. Cell Death Dis. 2024 Sep 8;15(9):658

TSS for Rps6kb1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr109850	Chr11:86435580-86435607 (-)	37 bp

Rps6kb1 is Candidate Gene for:

QTL	Genetic Location*	Genome Location (GRCm39)	Reference	QTL Note
Thcir2	Chr11, syntenic		J:314541	Top positional candidate genes include: Ndufs2 (MGI:2385112) for Thcir5; Scp2 (MGI:98254) for Thcir6; Rps6kb1 (MGI:1270849) for Thcir2; Pde4d (MGI:99555) for Thcir4; and Pten (MGI:109583) for Thcir3. These genes are likely to play a role in modulating initial response to THC based on location within modulatory QTL, putative functional sequence variants between B and D haplotypes that segregate among BXD progeny, evidence of genetic control of expression in brain tissue, and previously reported involvement in endocannabinoid/cannabinoid receptor signaling pathways.

*cM position of peak correlated region/marker

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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