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Plscr2 Gene Detail
Summary
  • Symbol
    Plscr2
  • Name
    phospholipid scramblase 2
  • Synonyms
    PL scramblase
  • Feature Type
    protein coding gene
  • IDs
    MGI:1270860
    NCBI Gene: 18828
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:92157655-92179805 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 48.35 cM, cytoband E3.3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    889 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1270860
 protein coding gene Chr9:92157655-92179805 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035127
 protein coding gene Chr9:93324995-93347791 (+)
A/J MGP_AJ_G0035108
 protein coding gene Chr9:90097015-90119588 (+)
AKR/J MGP_AKRJ_G0035040
 protein coding gene Chr9:92193310-92216193 (+)
BALB/cJ MGP_BALBcJ_G0035101
 protein coding gene Chr9:89745957-89768010 (+)
C3H/HeJ MGP_C3HHeJ_G0034811
 protein coding gene Chr9:92665342-92688621 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035621
 protein coding gene Chr9:95934211-95957280 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032524
 protein coding gene Chr9:88104569-88128662 (+)
CAST/EiJ MGP_CASTEiJ_G0034123
 protein coding gene Chr9:92403040-92426556 (+)
CBA/J MGP_CBAJ_G0034779
 protein coding gene Chr9:99269970-99295732 (+)
DBA/2J MGP_DBA2J_G0034941
 protein coding gene Chr9:89614573-89636542 (+)
FVB/NJ MGP_FVBNJ_G0034889
 protein coding gene Chr9:88579036-88600455 (+)
LP/J MGP_LPJ_G0035020
 protein coding gene Chr9:93521497-93548226 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034928
 protein coding gene Chr9:101205797-101228646 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035641
 protein coding gene Chr9:92474946-92498355 (+)
PWK/PhJ MGP_PWKPhJ_G0033830
 protein coding gene Chr9:89771313-89793526 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033665
 protein coding gene Chr9:92519401-92542159 (+)
WSB/EiJ MGP_WSBEiJ_G0034243
 protein coding gene Chr9:92352576-92375387 (+)



Homology
more
  • Human Ortholog
    PLSCR1, phospholipid scramblase 1
  • Vertebrate Orthologs
    7
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PLSCR1, phospholipid scramblase 1
  • Synonyms
    MMTRA1B
  • Links
    NCBI Gene ID: 5359
    neXtProt AC: NX_O15162
    UniProt: O15162

  • Chr Location
    3q24; chr3:146515180-146544856 (-)  GRCh38
  • Human Ortholog
    PLSCR2, phospholipid scramblase 2
  • Links
    NCBI Gene ID: 57047
    neXtProt AC: NX_Q9NRY7
    UniProt: Q9NRY7

  • Chr Location
    3q24; chr3:146391420-146495991 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    45
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    763
  • Tissues
    6
  • cDNA Data
    63
  • Literature Summary
    2
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 18828 NCBI Gene Model | MGI Sequence Detail 22151 C57BL/6J ±  kb
transcript NM_001195084 RefSeq | MGI Sequence Detail 1900 C57BL/6  
polypeptide Q9DCW2 UniProt | EBI | MGI Sequence Detail 307 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    3 Sequences
  • InterPro Domains
    IPR005552 Scramblase
Molecular
Reagents
less
  • All nucleic 63
    cDNA 63

    Microarray probesets 3
References
more
  • Summaries
    All 37
    Developmental Gene Expression 2
    Gene Ontology 9
    Phenotypes 8
  • Earliest
    J:46122 Zhou Q, et al., Identity of a conserved motif in phospholipid scramblase that is required for Ca2+-accelerated transbilayer movement of membrane phospholipids. Biochemistry. 1998 Feb 24;37(8):2356-60
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory