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Axin2 Gene Detail
Summary
  • Symbol
    Axin2
  • Name
    axin 2
  • Synonyms
    Axil, Conductin
  • Feature Type
    protein coding gene
  • IDs
    MGI:1270862
    NCBI Gene: 12006
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:108811175-108841609 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 71.83 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    784 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1270862
 protein coding gene Chr11:108808687-108841609 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019328
 protein coding gene Chr11:112406810-112445193 (+)
A/J MGP_AJ_G0019296
 protein coding gene Chr11:107576903-107610118 (+)
AKR/J MGP_AKRJ_G0019265
 protein coding gene Chr11:110778644-110812515 (+)
BALB/cJ MGP_BALBcJ_G0019270
 protein coding gene Chr11:108010646-108042075 (+)
C3H/HeJ MGP_C3HHeJ_G0019079
 protein coding gene Chr11:111109121-111141807 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019720
 protein coding gene Chr11:115841737-115878825 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017344
 protein coding gene Chr11:104814139-104844721 (+)
CAST/EiJ MGP_CASTEiJ_G0018633
 protein coding gene Chr11:112208525-112242361 (+)
CBA/J MGP_CBAJ_G0019048
 protein coding gene Chr11:120628646-120661985 (+)
DBA/2J MGP_DBA2J_G0019160
 protein coding gene Chr11:107058602-107091753 (+)
FVB/NJ MGP_FVBNJ_G0019151
 protein coding gene Chr11:106544218-106574820 (+)
LP/J MGP_LPJ_G0019230
 protein coding gene Chr11:112849501-112882370 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019182
 protein coding gene Chr11:119805215-119837511 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019757
 protein coding gene Chr11:111351852-111384874 (+)
PWK/PhJ MGP_PWKPhJ_G0018398
 protein coding gene Chr11:108206388-108237508 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018188
 protein coding gene Chr11:111126575-111160567 (+)
WSB/EiJ MGP_WSBEiJ_G0018684
 protein coding gene Chr11:111275435-111314389 (+)



Homology
more
  • Human Ortholog
    AXIN2, axin 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    AXIN2, axin 2
  • Synonyms
    AXIL, ODCRCS
  • Links
    NCBI Gene ID: 8313
    neXtProt AC: NX_Q9Y2T1
    UniProt: Q9Y2T1

  • Chr Location
    17q24.1; chr17:65528563-65561648 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Axin2 mouse models; 8 with human AXIN2 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    41 phenotypes from 5 alleles in 7 genetic backgrounds
    6 phenotypes from multigenic genotypes
    5 images
    254 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant mice exhibit premature fusion of cranial sutures, enhanced expansion of osteoprogenitors, accelerated ossification, and increased osteoblast proliferation and differentiation. Mice homozygous for a null reporter allele exhibit coloboma and small lens.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    78
  • GO References
    21
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    2234
  • Tissues
    660
  • cDNA Data
    66
  • Literature Summary
    500
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000000142 Ensembl Gene Model | MGI Sequence Detail 30435 C57BL/6J ±  kb
    transcript ENSMUST00000052915 Ensembl | MGI Sequence Detail 4260 Not Applicable  
    polypeptide ENSMUSP00000051331 Ensembl | MGI Sequence Detail 840 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 140
      cDNA 70
      Primer pair 26
      Other 44

      Microarray probesets 5
    References
    more
    • Summaries
      All 717
      Developmental Gene Expression 500
      Diseases 1
      Gene Ontology 21
      Phenotypes 254
    • Earliest
      J:47363 Behrens J, et al., Functional interaction of an axin homolog, conductin, with beta-catenin, APC, and GSK3beta. Science. 1998 Apr 24;280(5363):596-9
    • Latest
      J:357409 Padmanabhan A, et al., A genome-wide CRISPR screen identifies BRD4 as a regulator of cardiomyocyte differentiation. Nat Cardiovasc Res. 2024 Mar;3(3):317-331
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory