About   Help   FAQ
Robo1 Gene Detail
Summary
  • Symbol
    Robo1
  • Name
    roundabout guidance receptor 1
  • Synonyms
    DUTT1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1274781
    NCBI Gene: 19876
  • Alliance
    gene page
  • Transcription Start Sites
    25 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:72105194-72842983 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 41.08 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    23727 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1274781
 protein coding gene Chr16:71824406-72844379 (+)
129S1/SvImJ MGP_129S1SvImJ_G0022950
 protein coding gene Chr16:72564820-72961641 (+)
A/J MGP_AJ_G0022918
 protein coding gene Chr16:69366431-69751940 (+)
AKR/J MGP_AKRJ_G0022888
 protein coding gene Chr16:71477955-71864130 (+)
BALB/cJ MGP_BALBcJ_G0022920
 protein coding gene Chr16:69698817-70091442 (+)
C3H/HeJ MGP_C3HHeJ_G0022682
 protein coding gene Chr16:71902145-72306186 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023368
 protein coding gene Chr16:74886426-75304308 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020871
 protein coding gene Chr16:68028468-68405930 (+)
CAST/EiJ MGP_CASTEiJ_G0022205
 protein coding gene Chr16:72269730-72700469 (+)
CBA/J MGP_CBAJ_G0022652
 protein coding gene Chr16:78056970-78495283 (+)
DBA/2J MGP_DBA2J_G0022785
 protein coding gene Chr16:69214217-69598406 (+)
FVB/NJ MGP_FVBNJ_G0022760
 protein coding gene Chr16:68609338-68986055 (+)
LP/J MGP_LPJ_G0022855
 protein coding gene Chr16:72350001-72756553 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022778
 protein coding gene Chr16:80763521-81190540 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023385
 protein coding gene Chr16:71751343-72148300 (+)
PWK/PhJ MGP_PWKPhJ_G0021947
 protein coding gene Chr16:69442822-69863889 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021777
 protein coding gene Chr16:71416662-71826264 (+)
WSB/EiJ MGP_WSBEiJ_G0022252
 protein coding gene Chr16:71926708-72327549 (+)



Homology
more
  • Human Ortholog
    ROBO1, roundabout guidance receptor 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ROBO1, roundabout guidance receptor 1
  • Synonyms
    CPHD8, DUTT1, NORS, NYS8, SAX3
  • Links
    NCBI Gene ID: 6091
    neXtProt AC: NX_Q9Y6N7
    UniProt: Q9Y6N7

  • Chr Location
    3p12.3; chr3:78597239-79767998 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with Robo1 mouse models; 5 with human ROBO1 associations

Human Disease Mouse Models
      
IDs
 View 1 model
IDs
 View 1 model
      
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    55 phenotypes from 6 alleles in 8 genetic backgrounds
    22 phenotypes from multigenic genotypes
    35 images
    101 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice die at birth showing aberrant axon pathfinding and cortical interneuron migration. Homozygotes for one null allele show neonatal death, aphagia, delayed lung maturation and bronchial hyperplasia. Homozygotes for an ENU-induced mutation display craniofacial and cardiac anomalies and polycystic kidneys.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    57
  • GO References
    17
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1422
  • Tissues
    363
  • cDNA Data
    21
  • Literature Summary
    151
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022883 Ensembl Gene Model | MGI Sequence Detail 737790 C57BL/6J ±  kb
    transcript ENSMUST00000232205 Ensembl | MGI Sequence Detail 6601 Not Applicable  
    polypeptide ENSMUSP00000155958 Ensembl | MGI Sequence Detail 1622 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 47
      cDNA 33
      Primer pair 6
      Other 8

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:2146645, MGI:2146674
    References
    more
    • Summaries
      All 252
      Developmental Gene Expression 151
      Diseases 2
      Gene Ontology 17
      Phenotypes 101
    • Earliest
      J:47685 Sundaresan V, et al., The DUTT1 gene, a novel NCAM family member is expressed in developing murine neural tissues and has an unusually broad pattern of expression. Mol Cell Neurosci. 1998 May;11(1-2):29-35
    • Latest
      J:358594 Curran BM, et al., Multiple guidance mechanisms control axon growth to generate precise T-shaped bifurcation during dorsal funiculus development in the spinal cord. Elife. 2024 Aug 19;13
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory