Ccnk MGI Mouse Gene Detail - MGI:1276106

Symbol

Ccnk
Name

cyclin K
Synonyms

CPR4, CycK

Feature Type

protein coding gene
IDs

MGI:1276106
NCBI Gene: 12454
Alliance

gene page
Transcription Start Sites

11 TSS

Sequence Map

Chr12:108145838-108169618 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 59.23 cM, cytoband F1
Mapping Data

4 experiments

SNPs within 2kb

636 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1276106	protein coding gene	Chr12:108145543-108170252 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0020101	protein coding gene	Chr12:110261613-110287734 (+)
A/J	MGP_AJ_G0020055	protein coding gene	Chr12:106109373-106132970 (+)
AKR/J	MGP_AKRJ_G0020031	protein coding gene	Chr12:109176837-109199878 (+)
BALB/cJ	MGP_BALBcJ_G0020041	protein coding gene	Chr12:106512293-106536310 (+)
C3H/HeJ	MGP_C3HHeJ_G0019843	protein coding gene	Chr12:109618026-109640987 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020486	protein coding gene	Chr12:113650765-113676172 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018098	protein coding gene	Chr12:102642942-102666874 (+)
CAST/EiJ	MGP_CASTEiJ_G0019385	protein coding gene	Chr12:104538982-104567137 (+)
CBA/J	MGP_CBAJ_G0019810	protein coding gene	Chr12:118159853-118193897 (+)
DBA/2J	MGP_DBA2J_G0019927	protein coding gene	Chr12:105631943-105655456 (+)
FVB/NJ	MGP_FVBNJ_G0019912	protein coding gene	Chr12:104410280-104435116 (+)
LP/J	MGP_LPJ_G0020002	protein coding gene	Chr12:110140440-110163660 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019950	protein coding gene	Chr12:121389076-121416599 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020515	protein coding gene	Chr12:108632693-108656792 (+)
PWK/PhJ	MGP_PWKPhJ_G0019144	protein coding gene	Chr12:100242071-100266759 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018948	protein coding gene	Chr12:102846979-102874985 (+)
WSB/EiJ	MGP_WSBEiJ_G0019442	protein coding gene	Chr12:109576552-109603296 (+)

Human Ortholog

CCNK, cyclin K

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CCNK, cyclin K
Synonyms

CPR4, IDDHDF
Links

HGNC:1596

NCBI Gene ID: 8812

neXtProt AC: NX_O75909

UniProt: O75909
Chr Location

14q32.2; chr14:99481169-99535044 (+) GRCh38

MGI Vertebrate Homology

Ccnk stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CCNK
Gene Tree

Ccnk

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Endonuclease-mediated

3
Gene trapped

9
Targeted

2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

36 strains or lines available

Mice homozygous for a gene trap allele display complete embryonic lethality before implantation.

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All GO Annotations

25
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

730
Tissues

17
cDNA Data

45
Literature Summary

5

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA CCNK

Xenbase ccnk

ZFIN ccnk

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All Sequences

48
RefSeq

8
UniProt

4
CCDS

CCDS49165.1

Ensembl

ENSMUSG00000021258 (Evidence)
NCBI Gene

12454

			Length	Strain/Species	Flank
genomic	ENSMUSG00000021258	Ensembl Gene Model \| MGI Sequence Detail	23781	C57BL/6J	± kb
transcript	ENSMUST00000221167	Ensembl \| MGI Sequence Detail	2789	Not Applicable
polypeptide	ENSMUSP00000152784	Ensembl \| MGI Sequence Detail	582	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000005135 cyclin-K

(term hierarchy)
InterPro Domains

IPR004367 Cyclin, C-terminal domain

IPR043198 Cyclin/Cyclin-like subunit Ssn8

IPR013763 Cyclin-like domain

IPR036915 Cyclin-like superfamily

IPR006671 Cyclin, N-terminal

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All nucleic 48

cDNA 47

Primer pair 1

Microarray probesets 3

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MGI:2145008, MGI:2145025

Summaries

All 47

Developmental Gene Expression 5

Gene Ontology 11

Phenotypes 10
Earliest

J:48311 Edwards MC, et al., Human cyclin K, a novel RNA polymerase II-associated cyclin possessing both carboxy-terminal domain kinase and Cdk-activating kinase activity. Mol Cell Biol. 1998 Jul;18(7):4291-300
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Ccnk:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr114948	Chr12:108144742-108144756 (+)	-1,089 bp
Tssr114949	Chr12:108145110-108145119 (+)	-723 bp
Tssr114950	Chr12:108145392-108145393 (+)	-445 bp
Tssr114951	Chr12:108145395-108145428 (+)	-426 bp
Tssr114952	Chr12:108145802-108145841 (+)	-16 bp
Tssr114953	Chr12:108146052-108146090 (+)	233 bp
Tssr114954	Chr12:108146167-108146182 (+)	337 bp
Tssr114955	Chr12:108153430-108153444 (+)	7,599 bp
Tssr114956	Chr12:108155400-108155406 (+)	9,565 bp
Tssr114957	Chr12:108161953-108161972 (+)	16,125 bp
Tssr114958	Chr12:108168502-108168518 (+)	22,672 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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