Birc6 MGI Mouse Gene Detail - MGI:1276108 - baculoviral IAP repeat-containing 6

Symbol

Birc6
Name

baculoviral IAP repeat-containing 6
Synonyms

A430032G04Rik, A430040A19Rik, apollon, Bruce, D630005A10Rik

Feature Type

protein coding gene
IDs

MGI:1276108
NCBI Gene: 12211
Alliance

gene page
Transcription Start Sites

17 TSS

Sequence Map

Chr17:74835290-75010351 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 45.64 cM, cytoband E3
Mapping Data

3 experiments

SNPs within 2kb

4181 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1276108	protein coding gene	Chr17:74835247-75010351 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0024031	protein coding gene	Chr17:77188969-77380698 (+)
A/J	MGP_AJ_G0023988	protein coding gene	Chr17:74816304-74993622 (+)
AKR/J	MGP_AKRJ_G0023957	protein coding gene	Chr17:75891146-76081684 (+)
BALB/cJ	MGP_BALBcJ_G0023990	protein coding gene	Chr17:74712032-74889413 (+)
C3H/HeJ	MGP_C3HHeJ_G0023754	protein coding gene	Chr17:76810774-76992730 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0024435	protein coding gene	Chr17:79951941-80151638 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021879	protein coding gene	Chr17:70439574-70614074 (+)
CAST/EiJ	MGP_CASTEiJ_G0023234	protein coding gene	Chr17:77334237-77523995 (+)
CBA/J	MGP_CBAJ_G0023728	protein coding gene	Chr17:83310270-83511302 (+)
DBA/2J	MGP_DBA2J_G0023857	protein coding gene	Chr17:73395552-73572187 (+)
FVB/NJ	MGP_FVBNJ_G0023823	protein coding gene	Chr17:72898922-73083012 (+)
LP/J	MGP_LPJ_G0023940	protein coding gene	Chr17:77945024-78149263 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023851	protein coding gene	Chr17:83117367-83308564 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024479	protein coding gene	Chr17:76366415-76545983 (+)
PWK/PhJ	MGP_PWKPhJ_G0022980	protein coding gene	Chr17:72778038-72959675 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0022791	protein coding gene	Chr17:73077106-73272195 (+)
WSB/EiJ	MGP_WSBEiJ_G0023301	protein coding gene	Chr17:77229167-77418964 (+)

Human Ortholog

BIRC6, baculoviral IAP repeat containing 6

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

BIRC6, baculoviral IAP repeat containing 6
Synonyms

APOLLON, BRUCE
Links

HGNC:13516

NCBI Gene ID: 57448

neXtProt AC: NX_Q9NR09

UniProt: Q9NR09
Chr Location

2p22.3; chr2:32357023-32619571 (+) GRCh38

MGI Vertebrate Homology

Birc6 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: BIRC6
Gene Tree

Birc6

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Phenotype Summary

32 phenotypes from 7 alleles in 6 genetic backgrounds
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

66
Chemically induced (ENU)

1
Endonuclease-mediated

1
Gene trapped

62
Targeted

2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

240 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous mice exhibit perinatal lethality and exhibit placental defects.

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All GO Annotations

38
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

755
Tissues

30
cDNA Data

29
Literature Summary

7

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase birc6

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All Sequences

147
RefSeq

48
UniProt

14
CCDS

CCDS37693.2

Ensembl

ENSMUSG00000024073 (Evidence)
NCBI Gene

12211

			Length	Strain/Species	Flank
genomic	ENSMUSG00000024073	Ensembl Gene Model \| MGI Sequence Detail	175062	C57BL/6J	± kb
transcript	ENSMUST00000182597	Ensembl \| MGI Sequence Detail	14649	Not Applicable
polypeptide	ENSMUSP00000138333	Ensembl \| MGI Sequence Detail	4882	Not Applicable

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UniProt

14 Sequences
Protein Ontology

PR:000004754 baculoviral IAP repeat-containing protein 6

(term hierarchy)
PDB

8IVQ
EC

2.3.2.24
InterPro Domains

IPR022103 Baculoviral IAP repeat-containing protein 6

IPR001370 BIR repeat

IPR000608 Ubiquitin-conjugating enzyme E2

IPR016135 Ubiquitin-conjugating enzyme/RWD-like

IPR036322 WD40-repeat-containing domain superfamily
GlyGen

O88738 5 sites, 4 N-linked glycans (4 sites), 1 O-linked glycan (1 site)

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All nucleic 33

cDNA 33

Microarray probesets 5

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MGI:2442816, MGI:2444799, MGI:2444861, MGI:3034286

Summaries

All 57

Developmental Gene Expression 7

Gene Ontology 11

Phenotypes 16
Earliest

J:48143 Hauser HP, et al., A giant ubiquitin-conjugating enzyme related to IAP apoptosis inhibitors. J Cell Biol. 1998 Jun 15;141(6):1415-22
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Birc6:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr145841	Chr17:74835274-74835283 (+)	-11 bp
Tssr145842	Chr17:74835319-74835365 (+)	52 bp
Tssr145843	Chr17:74835391-74835396 (+)	104 bp
Tssr145844	Chr17:74835417-74835428 (+)	133 bp
Tssr145845	Chr17:74835430-74835460 (+)	155 bp
Tssr145846	Chr17:74835462-74835542 (+)	212 bp
Tssr145847	Chr17:74856578-74856593 (+)	21,296 bp
Tssr145848	Chr17:74863776-74863781 (+)	28,489 bp
Tssr145849	Chr17:74877598-74877609 (+)	42,314 bp
Tssr145850	Chr17:74906206-74906227 (+)	70,927 bp
Tssr145851	Chr17:74943115-74943155 (+)	107,845 bp
Tssr145852	Chr17:74972763-74972772 (+)	137,478 bp
Tssr145853	Chr17:74975268-74975277 (+)	139,983 bp
Tssr145854	Chr17:74977271-74977303 (+)	141,997 bp
Tssr145855	Chr17:74977320-74977331 (+)	142,036 bp
Tssr145856	Chr17:74989417-74989420 (+)	154,129 bp
Tssr145857	Chr17:75009719-75009722 (+)	174,431 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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