Cldn2 MGI Mouse Gene Detail - MGI:1276110

Symbol

Cldn2
Name

claudin 2

Feature Type

protein coding gene
IDs

MGI:1276110
NCBI Gene: 12738
Alliance

gene page
Transcription Start Sites

16 TSS

Sequence Map

ChrX:138701577-138712135 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome X, 61.35 cM
Mapping Data

2 experiments

SNPs within 2kb

213 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1276110	protein coding gene	ChrX:138701552-138712135 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0036128	protein coding gene	ChrX:137314149-137324784 (+)
A/J	MGP_AJ_G0036106	protein coding gene	ChrX:136692256-136709253 (+)
AKR/J	MGP_AKRJ_G0036031	protein coding gene	ChrX:141088688-141099266 (+)
BALB/cJ	MGP_BALBcJ_G0036096	protein coding gene	ChrX:135041740-135052322 (+)
C3H/HeJ	MGP_C3HHeJ_G0035805	protein coding gene	ChrX:137348558-137359121 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0036621	protein coding gene	ChrX:141351626-141362182 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0033445	protein coding gene	ChrX:128449698-128460443 (+)
CAST/EiJ	MGP_CASTEiJ_G0035096	protein coding gene	ChrX:118148724-118159314 (+)
CBA/J	MGP_CBAJ_G0035782	protein coding gene	ChrX:145682535-145693092 (+)
DBA/2J	MGP_DBA2J_G0035939	protein coding gene	ChrX:135869103-135879658 (+)
FVB/NJ	MGP_FVBNJ_G0035873	protein coding gene	ChrX:135102041-135112619 (+)
LP/J	MGP_LPJ_G0036030	protein coding gene	ChrX:138286686-138297268 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0035910	protein coding gene	ChrX:153199393-153209957 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0036657	protein coding gene	ChrX:136625816-136636372 (+)
PWK/PhJ	MGP_PWKPhJ_G0034789	protein coding gene	ChrX:115072508-115083209 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0034615	protein coding gene	ChrX:118683562-118694201 (+)
WSB/EiJ	MGP_WSBEiJ_G0035231	protein coding gene	ChrX:134952469-134963028 (+)

Human Ortholog

CLDN2, claudin 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CLDN2, claudin 2
Synonyms

claudin-2, OAZON
Links

HGNC:2041

NCBI Gene ID: 9075

neXtProt AC: NX_P57739

UniProt: P57739
Chr Location

Xq22.3; chrX:106900164-106930861 (+) GRCh38

MGI Vertebrate Homology

Cldn2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CLDN2
Gene Tree

Cldn2

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Phenotype Summary

15 phenotypes from 2 alleles in 2 genetic backgrounds
1 images
21 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Endonuclease-mediated

3
Targeted

5
Find Mice (IMSR)

10 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Nullizygous females show altered Na+ and water reabsorption in the kidney proximal tubules. Males hemizygous for a null allele show increased transcellular Na+ reabsorption in the thick ascending limb, higher renal oxygen consumption, medullary hypoxia, and susceptibility to ischemic renal injury.

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All GO Annotations

25
GO References

17

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

830
Tissues

53
cDNA Data

84
Literature Summary

22

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cldn2

ZFIN cldn2

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All Sequences

47
RefSeq

12
UniProt

2
CCDS

CCDS30437.1

Ensembl

ENSMUSG00000047230 (Evidence)
NCBI Gene

12738

			Length	Strain/Species	Flank
genomic	ENSMUSG00000047230	Ensembl Gene Model \| MGI Sequence Detail	10559	C57BL/6J	± kb
transcript	ENSMUST00000054889	Ensembl \| MGI Sequence Detail	3044	Not Applicable
polypeptide	ENSMUSP00000054219	Ensembl \| MGI Sequence Detail	230	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000005547 claudin-2

(term hierarchy)
PDB

4P5H
InterPro Domains

IPR006187 Claudin

IPR005411 Claudin-2

IPR017974 Claudin, conserved site

IPR004031 PMP-22/EMP/MP20/Claudin

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All nucleic 91

cDNA 84

Primer pair 6

Other 1

Microarray probesets 4

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MGI:2147942

Summaries

All 87

Developmental Gene Expression 22

Gene Ontology 17

Phenotypes 21
Earliest

J:48635 Furuse M, et al., Claudin-1 and -2: novel integral membrane proteins localizing at tight junctions with no sequence similarity to occludin. J Cell Biol. 1998 Jun 29;141(7):1539-50
Latest

J:350124 Beggs MR, et al., Maternal Epidermal Growth Factor Promotes Neonatal Claudin-2 Dependent Increases in Small Intestinal Calcium Permeability. Function (Oxf). 2023;4(5):zqad033

TSS for Cldn2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr162181	ChrX:138701448-138701473 (+)	-116 bp
Tssr162182	ChrX:138701479-138701490 (+)	-92 bp
Tssr162183	ChrX:138701544-138701560 (+)	-25 bp
Tssr162184	ChrX:138701692-138701712 (+)	125 bp
Tssr162185	ChrX:138701717-138701728 (+)	146 bp
Tssr162186	ChrX:138701730-138701741 (+)	159 bp
Tssr162187	ChrX:138706813-138706816 (+)	5,238 bp
Tssr162188	ChrX:138706818-138706828 (+)	5,246 bp
Tssr5687	ChrX:138708259-138708261 (+)	6,683 bp
Tssr162189	ChrX:138708507-138708517 (+)	6,935 bp
Tssr162190	ChrX:138709002-138709016 (+)	7,432 bp
Tssr162191	ChrX:138709020-138709039 (+)	7,453 bp
Tssr162192	ChrX:138709266-138709325 (+)	7,719 bp
Tssr162193	ChrX:138709344-138709377 (+)	7,784 bp
Tssr162194	ChrX:138709382-138709398 (+)	7,813 bp
Tssr162195	ChrX:138709855-138709873 (+)	8,287 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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