Slc13a2 MGI Mouse Gene Detail - MGI:1276558 - solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2

Symbol

Slc13a2
Name

solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2
Synonyms

mNaDC-1, Nadc1, sodium/dicarboxylate co-transporter

Feature Type

protein coding gene
IDs

MGI:1276558
NCBI Gene: 20500
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr11:78288102-78313107 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 46.74 cM
Mapping Data

3 experiments

SNPs within 2kb

690 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1276558	protein coding gene	Chr11:78287913-78313107 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0018779	protein coding gene	Chr11:79405208-79430319 (-)
A/J	MGP_AJ_G0018745	protein coding gene	Chr11:76364885-76389965 (-)
AKR/J	MGP_AKRJ_G0018715	protein coding gene	Chr11:78667301-78692429 (-)
BALB/cJ	MGP_BALBcJ_G0018719	protein coding gene	Chr11:76770225-76795341 (-)
C3H/HeJ	MGP_C3HHeJ_G0018532	protein coding gene	Chr11:78716646-78741766 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0019170	protein coding gene	Chr11:81874334-81899779 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016805	protein coding gene	Chr11:73338324-73364248 (-)
CAST/EiJ	MGP_CASTEiJ_G0018086	protein coding gene	Chr11:79166854-79192048 (-)
CBA/J	MGP_CBAJ_G0018503	protein coding gene	Chr11:85466745-85493659 (-)
DBA/2J	MGP_DBA2J_G0018611	protein coding gene	Chr11:75941445-75966513 (-)
FVB/NJ	MGP_FVBNJ_G0018601	protein coding gene	Chr11:75529671-75554807 (-)
LP/J	MGP_LPJ_G0018682	protein coding gene	Chr11:79928572-79953722 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018627	protein coding gene	Chr11:85852643-85877765 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019210	protein coding gene	Chr11:78914989-78940100 (-)
PWK/PhJ	MGP_PWKPhJ_G0017857	protein coding gene	Chr11:76734265-76760022 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0017648	protein coding gene	Chr11:78525506-78550848 (-)
WSB/EiJ	MGP_WSBEiJ_G0018139	protein coding gene	Chr11:78744895-78769941 (-)

Human Ortholog

SLC13A2, solute carrier family 13 member 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SLC13A2, solute carrier family 13 member 2
Synonyms

NaCT, NaDC-1, NADC1, SDCT1
Links

HGNC:10917

NCBI Gene ID: 9058

neXtProt AC: NX_Q13183

UniProt: Q13183
Chr Location

17q11.2; chr17:28473293-28497781 (+) GRCh38

MGI Vertebrate Homology

Slc13a2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SLC13A2
Gene Tree

Slc13a2

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
18 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

13
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

6
Targeted

5
Genomic Mutations

3 involving Slc13a2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

43 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit increased Kreb cycle intermediates in the urine but otherwise have normal kidney function and response to ischemia-reperfusion injury and caloric restriction.

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All GO Annotations

38
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

933
Tissues

118
cDNA Data

30
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase slc13a2

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All Sequences

39
RefSeq

11
UniProt

1
CCDS

CCDS25103.1

Ensembl

ENSMUSG00000001095 (Evidence)
NCBI Gene

20500

			Length	Strain/Species	Flank
genomic	20500	NCBI Gene Model \| MGI Sequence Detail	25006	C57BL/6J	± kb
transcript	NM_022411	RefSeq \| MGI Sequence Detail	2240	ZRU/MplStud
polypeptide	Q9ES88	UniProt \| EBI \| MGI Sequence Detail	586	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000014934 solute carrier family 13 member 2

(term hierarchy)
InterPro Domains

IPR031312 Sodium/sulphate symporter, conserved site

IPR001898 Solute carrier family 13

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All nucleic 34

Genomic 1

cDNA 31

Primer pair 2

Microarray probesets 3

Summaries

All 50

Developmental Gene Expression 3

Gene Ontology 8

Phenotypes 18
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:316399 LassegueI B, et al., Characterization of Poldip2 knockout mice: Avoiding incorrect gene targeting. PLoS One. 2021;16(12)

TSS for Slc13a2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr109398	Chr11:78313049-78313066 (-)	49 bp
Tssr109397	Chr11:78295448-78295462 (-)	17,652 bp
Tssr109396	Chr11:78295412-78295433 (-)	17,684 bp
Tssr109395	Chr11:78295400-78295409 (-)	17,702 bp
Tssr109394	Chr11:78291644-78291655 (-)	21,457 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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