Gfi1b MGI Mouse Gene Detail - MGI:1276578 - growth factor independent 1B

Symbol

Gfi1b
Name

growth factor independent 1B
Synonyms

Gfi-1B

Feature Type

protein coding gene
IDs

MGI:1276578
NCBI Gene: 14582
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr2:28499462-28511994 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 19.38 cM
Mapping Data

2 experiments

SNPs within 2kb

374 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1276578	protein coding gene	Chr2:28499462-28511994 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0025528	protein coding gene	Chr2:26682197-26695893 (-)
A/J	MGP_AJ_G0025505	protein coding gene	Chr2:25662453-25674985 (-)
AKR/J	MGP_AKRJ_G0025475	protein coding gene	Chr2:26514177-26526692 (-)
BALB/cJ	MGP_BALBcJ_G0025501	protein coding gene	Chr2:25783008-25795551 (-)
C3H/HeJ	MGP_C3HHeJ_G0025262	protein coding gene	Chr2:26436291-26448814 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0025945	protein coding gene	Chr2:27570098-27582613 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023355	protein coding gene	Chr2:24476025-24488994 (-)
CAST/EiJ	MGP_CASTEiJ_G0024725	protein coding gene	Chr2:26338653-26353098 (-)
CBA/J	MGP_CBAJ_G0025240	protein coding gene	Chr2:28507436-28519949 (-)
DBA/2J	MGP_DBA2J_G0025373	protein coding gene	Chr2:25471489-25484253 (-)
FVB/NJ	MGP_FVBNJ_G0025335	protein coding gene	Chr2:25257182-25269872 (-)
LP/J	MGP_LPJ_G0025459	protein coding gene	Chr2:26629361-26641899 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025366	protein coding gene	Chr2:28523902-28536423 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026004	protein coding gene	Chr2:26433331-26445862 (-)
PWK/PhJ	MGP_PWKPhJ_G0024472	protein coding gene	Chr2:25282230-25295376 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0024272	protein coding gene	Chr2:26557638-26570142 (-)
WSB/EiJ	MGP_WSBEiJ_G0024794	protein coding gene	Chr2:26563440-26577427 (-)

Human Ortholog

GFI1B, growth factor independent 1B transcriptional repressor

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GFI1B, growth factor independent 1B transcriptional repressor
Synonyms

BDPLT17, ZNF163B
Links

HGNC:4238

NCBI Gene ID: 8328

neXtProt AC: NX_Q5VTD9

UniProt: Q5VTD9
Chr Location

9q34.13; chr9:132944000-132993434 (+) GRCh38

MGI Vertebrate Homology

Gfi1b stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: GFI1B
Gene Tree

Gfi1b

Diseases

2 with human GFI1B associations

				Human Disease	Mouse Models
				gray platelet syndrome IDs gray platelet syndrome DOID:0111044 ICD10CM:D69.1 MESH:D055652 NCI:C84741 OMIM:139090 ORDO:721 UMLS_CUI:C0272302
				platelet-type bleeding disorder 17 IDs platelet-type bleeding disorder 17 DOID:0111049 ICD10CM:D69.1 MESH:D055652 NCI:C84741 OMIM:187900 UMLS_CUI:C0272302

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

31 phenotypes from 5 alleles in 5 genetic backgrounds
1 phenotype from multigenic genotypes
26 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Endonuclease-mediated

2
Gene trapped

1
Targeted

8
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

21 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for disruption of this gene die as embryos by day E15. Mature adult red blood cells and megakaryocytes fail to develop.

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All GO Annotations

23
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

837
Tissues

27
cDNA Data

19
Literature Summary

15

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA GFI1B

Xenbase gfi1b

ZFIN gfi1b

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All Sequences

40
RefSeq

4
UniProt

2
CCDS

CCDS15843.1, CCDS50549.1

Ensembl

ENSMUSG00000026815 (Evidence)
NCBI Gene

14582

			Length	Strain/Species	Flank
genomic	14582	NCBI Gene Model \| MGI Sequence Detail	12533	C57BL/6J	± kb
transcript	NM_001160406	RefSeq \| MGI Sequence Detail	1778	C57BL/6
polypeptide	O70237	UniProt \| EBI \| MGI Sequence Detail	330	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000007942 zinc finger protein Gfi-1b

(term hierarchy)
InterPro Domains

IPR036236 Zinc finger C2H2 superfamily

IPR013087 Zinc finger C2H2-type

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All nucleic 22

cDNA 19

Primer pair 3

Microarray probesets 3

Summaries

All 78

Developmental Gene Expression 15

Gene Ontology 8

Phenotypes 26
Earliest

J:47010 Tong B, et al., The Gfi-1B proto-oncoprotein represses p21WAF1 and inhibits myeloid cell differentiation. Mol Cell Biol. 1998 May;18(5):2462-73
Latest

J:346895 Guo P, et al., A methylation-phosphorylation switch controls EZH2 stability and hematopoiesis. Elife. 2024 Feb 12;13

TSS for Gfi1b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr23290	Chr2:28511944-28511975 (-)	34 bp
Tssr23289	Chr2:28511914-28511925 (-)	74 bp
Tssr23288	Chr2:28511330-28511342 (-)	658 bp
Tssr23287	Chr2:28510685-28510688 (-)	1,307 bp
Tssr23286	Chr2:28505347-28505358 (-)	6,641 bp
Tssr23285	Chr2:28503380-28503383 (-)	8,612 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/05/2024 MGI 6.24