Nudcd2 MGI Mouse Gene Detail - MGI:1277103

Symbol

Nudcd2
Name

NudC domain containing 2
Synonyms

2700047N05Rik, D11Ertd603e

Feature Type

protein coding gene
IDs

MGI:1277103
NCBI Gene: 52653
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr11:40624494-40630873 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 24.41 cM
Mapping Data

2 experiments

SNPs within 2kb

302 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1277103	protein coding gene	Chr11:40624485-40630873 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018162	protein coding gene	Chr11:39400168-39406541 (+)
A/J	MGP_AJ_G0018135	protein coding gene	Chr11:37907476-37913849 (+)
AKR/J	MGP_AKRJ_G0018099	protein coding gene	Chr11:39020273-39026645 (+)
BALB/cJ	MGP_BALBcJ_G0018104	protein coding gene	Chr11:38101915-38108400 (+)
C3H/HeJ	MGP_C3HHeJ_G0017917	protein coding gene	Chr11:39047257-39053630 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018558	protein coding gene	Chr11:40584949-40591328 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016213	protein coding gene	Chr11:36135519-36141896 (+)
CAST/EiJ	MGP_CASTEiJ_G0017481	protein coding gene	Chr11:39075927-39082302 (+)
CBA/J	MGP_CBAJ_G0017890	protein coding gene	Chr11:42494448-42500821 (+)
DBA/2J	MGP_DBA2J_G0018000	protein coding gene	Chr11:37658346-37664887 (+)
FVB/NJ	MGP_FVBNJ_G0017994	protein coding gene	Chr11:37409961-37416340 (+)
LP/J	MGP_LPJ_G0018072	protein coding gene	Chr11:39638945-39645318 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018018	protein coding gene	Chr11:43788439-43794818 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018597	protein coding gene	Chr11:39086413-39092792 (+)
PWK/PhJ	MGP_PWKPhJ_G0017262	protein coding gene	Chr11:37733654-37740218 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017054	protein coding gene	Chr11:38918201-38924566 (+)
WSB/EiJ	MGP_WSBEiJ_G0017530	protein coding gene	Chr11:38808727-38815106 (+)

Human Ortholog

NUDCD2, NudC domain containing 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NUDCD2, NudC domain containing 2
Synonyms

NudCL2
Links

HGNC:30535

NCBI Gene ID: 134492

neXtProt AC: NX_Q8WVJ2

UniProt: Q8WVJ2
Chr Location

5q34; chr5:163446526-163460102 (-) GRCh38

MGI Vertebrate Homology

Nudcd2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: NUDCD2
Gene Tree

Nudcd2

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

38
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

34
Radiation induced

1
Targeted

1
Genomic Mutations

2 involving Nudcd2
Incidental Mutations

APF
Find Mice (IMSR)

19 strains or lines available

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All GO Annotations

13
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

707
Tissues

1
cDNA Data

11
Literature Summary

1

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase nudcd2

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All Sequences

51
RefSeq

6
UniProt

2
CCDS

CCDS24549.1, CCDS70162.1

Ensembl

ENSMUSG00000020328 (Evidence)
NCBI Gene

52653

			Length	Strain/Species	Flank
genomic	ENSMUSG00000020328	Ensembl Gene Model \| MGI Sequence Detail	6380	C57BL/6J	± kb
transcript	ENSMUST00000020578	Ensembl \| MGI Sequence Detail	1577	Not Applicable
polypeptide	ENSMUSP00000020578	Ensembl \| MGI Sequence Detail	157	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000031537 NudC domain-containing protein 2

(term hierarchy)
PDB

2RH0
InterPro Domains

IPR007052 CS domain

IPR008978 HSP20-like chaperone

IPR037902 NudC domain-containing protein 2, p23 domain

IPR037898 NudC family
GlyGen

Q9CQ48 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)

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All nucleic 12

cDNA 11

Primer pair 1

Microarray probesets 6

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MGI:1914441

Summaries

All 37

Developmental Gene Expression 1

Gene Ontology 5

Phenotypes 13
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Nudcd2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr100961	Chr11:40624449-40624458 (+)	-40 bp
Tssr100962	Chr11:40624466-40624530 (+)	4 bp
Tssr100963	Chr11:40624554-40624589 (+)	78 bp
Tssr100964	Chr11:40624704-40624758 (+)	237 bp
Tssr100965	Chr11:40624763-40624774 (+)	275 bp
Tssr100966	Chr11:40624920-40624984 (+)	458 bp
Tssr100967	Chr11:40624998-40625018 (+)	514 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24