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Ptgfrn Gene Detail
Summary
  • Symbol
    Ptgfrn
  • Name
    prostaglandin F2 receptor negative regulator
  • Synonyms
    4833445A08Rik, CD9P-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1277114
    NCBI Gene: 19221
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:100947548-101017594 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 43.93 cM, cytoband F3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    546 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1277114
 protein coding gene Chr3:100947546-101018061 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027673
 protein coding gene Chr3:102186984-102262195 (-)
A/J MGP_AJ_G0027632
 protein coding gene Chr3:98965625-99035950 (-)
AKR/J MGP_AKRJ_G0027598
 protein coding gene Chr3:101396077-101467044 (-)
BALB/cJ MGP_BALBcJ_G0027645
 protein coding gene Chr3:98722132-98791688 (-)
C3H/HeJ MGP_C3HHeJ_G0027374
 protein coding gene Chr3:101685389-101761210 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028088
 protein coding gene Chr3:105936873-106013868 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025429
 protein coding gene Chr3:95163298-95233753 (-)
CAST/EiJ MGP_CASTEiJ_G0026830
 protein coding gene Chr3:100789153-100861035 (-)
CBA/J MGP_CBAJ_G0027349
 protein coding gene Chr3:109586603-109660248 (-)
DBA/2J MGP_DBA2J_G0027492
 protein coding gene Chr3:98203217-98275852 (-)
FVB/NJ MGP_FVBNJ_G0027460
 protein coding gene Chr3:96136540-96206443 (-)
LP/J MGP_LPJ_G0027599
 protein coding gene Chr3:103545878-103618257 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027490
 protein coding gene Chr3:115802873-115875690 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028143
 protein coding gene Chr3:100881191-100954079 (-)
PWK/PhJ MGP_PWKPhJ_G0026557
 protein coding gene Chr3:97959918-98030496 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026379
 protein coding gene Chr3:98975483-99044164 (-)
WSB/EiJ MGP_WSBEiJ_G0026910
 protein coding gene Chr3:101439757-101511983 (-)



Homology
more
  • Human Ortholog
    PTGFRN, prostaglandin F2 receptor inhibitor
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PTGFRN, prostaglandin F2 receptor inhibitor
  • Synonyms
    CD315, CD9P-1, EWI-F, FPRP, SMAP-6
  • Links
    NCBI Gene ID: 5738
    neXtProt AC: NX_Q9P2B2
    UniProt: Q9P2B2

  • Chr Location
    1p13.1; chr1:116909916-116990353 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    30
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    3
  • Gene trapped
    23
  • Radiation induced
    1
  • Targeted
    2
  • Genomic Mutations
    2 involving Ptgfrn
  • Incidental Mutations
    APF , CvDC
  • Find Mice (IMSR)
    46 strains or lines available
Homozygous mice for a null gene trap mutation exhibit a decreased depressive-like response during tail suspension testing when compared with their wild-type littermates,
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    6
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    850
  • Tissues
    21
  • cDNA Data
    59
  • Literature Summary
    5
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000027864 Ensembl Gene Model | MGI Sequence Detail 70047 C57BL/6J ±  kb
transcript ENSMUST00000102694 Ensembl | MGI Sequence Detail 5902 Not Applicable  
polypeptide ENSMUSP00000099755 Ensembl | MGI Sequence Detail 879 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000001920 prostaglandin F2 receptor negative regulator
    (term hierarchy)
  • InterPro Domains
    IPR007110 Immunoglobulin-like domain
    IPR036179 Immunoglobulin-like domain superfamily
    IPR013783 Immunoglobulin-like fold
    IPR003599 Immunoglobulin subtype
    IPR051102 Immunoglobulin superfamily V-set and transmembrane domain-containing protein
    IPR013106 Immunoglobulin V-set domain
  • GlyGen
    Q9WV91 9 sites, 6 N-linked glycans (5 sites), 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 62
    cDNA 60
    Primer pair 1
    Other 1

    Microarray probesets 5
Other
Accession IDs
less
MGI:2139911
References
more
  • Summaries
    All 47
    Developmental Gene Expression 5
    Diseases 1
    Gene Ontology 4
    Phenotypes 15
  • Earliest
    J:48914 Orlicky DJ, et al., Cloning, sequencing and proposed structure for a prostaglandin F2 alpha receptor regulatory protein. Prostaglandins Leukot Essent Fatty Acids. 1996 Oct;55(4):261-8
  • Latest
    J:313619 Bedogni F, et al., Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory