Pde8a MGI Mouse Gene Detail - MGI:1277116

Symbol

Pde8a
Name

phosphodiesterase 8A
Synonyms

Pde8

Feature Type

protein coding gene
IDs

MGI:1277116
NCBI Gene: 18584
Alliance

gene page
Transcription Start Sites

14 TSS

Sequence Map

Chr7:80863344-80984281 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 45.71 cM
Mapping Data

2 experiments

SNPs within 2kb

2965 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1277116	protein coding gene	Chr7:80863013-80984283 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0032426	protein coding gene	Chr7:83253560-83390524 (+)
A/J	MGP_AJ_G0032405	protein coding gene	Chr7:81294281-81421826 (+)
AKR/J	MGP_AKRJ_G0032341	protein coding gene	Chr7:83091173-83228518 (+)
BALB/cJ	MGP_BALBcJ_G0032417	protein coding gene	Chr7:80957250-81082450 (+)
C3H/HeJ	MGP_C3HHeJ_G0032130	protein coding gene	Chr7:83706097-83837269 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0032909	protein coding gene	Chr7:86521120-86657819 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0029917	protein coding gene	Chr7:83783736-83906381 (+)
CAST/EiJ	MGP_CASTEiJ_G0031458	protein coding gene	Chr7:74626505-74772384 (+)
CBA/J	MGP_CBAJ_G0032096	protein coding gene	Chr7:89422754-89561511 (+)
DBA/2J	MGP_DBA2J_G0032251	protein coding gene	Chr7:79831652-79953025 (+)
FVB/NJ	MGP_FVBNJ_G0032206	protein coding gene	Chr7:79760909-79886633 (+)
LP/J	MGP_LPJ_G0032332	protein coding gene	Chr7:84489571-84621698 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0032243	protein coding gene	Chr7:89496283-89627220 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0032927	protein coding gene	Chr7:82500930-82631205 (+)
PWK/PhJ	MGP_PWKPhJ_G0031178	protein coding gene	Chr7:73042470-73166699 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0031019	protein coding gene	Chr7:69509812-69643839 (+)
WSB/EiJ	MGP_WSBEiJ_G0031576	protein coding gene	Chr7:82865457-82996618 (+)

Human Ortholog

PDE8A, phosphodiesterase 8A

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PDE8A, phosphodiesterase 8A
Synonyms

HsT19550
Links

HGNC:8793

NCBI Gene ID: 5151

neXtProt AC: NX_O60658

UniProt: O60658
Chr Location

15q25.3; chr15:84980440-85139145 (+) GRCh38

MGI Vertebrate Homology

Pde8a stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PDE8A
Gene Tree

Pde8a

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Phenotype Summary

6 phenotypes from 2 alleles in 3 genetic backgrounds
1 phenotype from multigenic genotypes
26 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

2
Radiation induced

2
Targeted

3
Genomic Mutations

3 involving Pde8a
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

55 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Targeted disruption of this gene results in a 4-fold increase in basal release of testosterone in isolated Leydig cells as well as a significant increase in the sensitivity to luteinizing hormone, measured as testosterone released into the media.

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All GO Annotations

20
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

921
Tissues

154
cDNA Data

46
Literature Summary

7

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase pde8a

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All Sequences

42
RefSeq

4
UniProt

3
CCDS

CCDS40005.1

Ensembl

ENSMUSG00000025584 (Evidence)
NCBI Gene

18584

			Length	Strain/Species	Flank
genomic	ENSMUSG00000025584	Ensembl Gene Model \| MGI Sequence Detail	120938	C57BL/6J	± kb
transcript	ENSMUST00000026672	Ensembl \| MGI Sequence Detail	3802	Not Applicable
polypeptide	ENSMUSP00000026672	Ensembl \| MGI Sequence Detail	823	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000012486 high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A

(term hierarchy)
EC

3.1.4.-, 3.1.4.53
InterPro Domains

IPR023088 3'5'-cyclic nucleotide phosphodiesterase

IPR002073 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain

IPR036971 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily

IPR023174 3'5'-cyclic nucleotide phosphodiesterase, conserved site

IPR011006 CheY-like superfamily

IPR003607 HD/PDEase domain

IPR000014 PAS domain

IPR035965 PAS domain superfamily

IPR013767 PAS fold
GlyGen

O88502 1 site, 1 N-linked glycan (1 site)

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All nucleic 51

cDNA 47

Primer pair 3

Other 1

Microarray probesets 4

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MGI:2141996

Summaries

All 59

Developmental Gene Expression 7

Gene Ontology 8

Phenotypes 26
Earliest

J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Pde8a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr67494	Chr7:80863006-80863032 (+)	-325 bp
Tssr67495	Chr7:80863035-80863070 (+)	-291 bp
Tssr67496	Chr7:80863071-80863090 (+)	-263 bp
Tssr67497	Chr7:80863093-80863107 (+)	-244 bp
Tssr67498	Chr7:80863242-80863244 (+)	-101 bp
Tssr67499	Chr7:80863315-80863380 (+)	4 bp
Tssr67500	Chr7:80863499-80863511 (+)	161 bp
Tssr67501	Chr7:80863525-80863624 (+)	231 bp
Tssr67502	Chr7:80863793-80863814 (+)	460 bp
Tssr67503	Chr7:80871809-80871812 (+)	8,467 bp
Tssr67504	Chr7:80876190-80876194 (+)	12,848 bp
Tssr67505	Chr7:80892893-80892897 (+)	29,551 bp
Tssr67506	Chr7:80946295-80946303 (+)	82,955 bp
Tssr2314	Chr7:80963642-80963645 (+)	100,300 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24