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Gtf2h3 Gene Detail
Summary
  • Symbol
    Gtf2h3
  • Name
    general transcription factor IIH, polypeptide 3
  • Synonyms
    34kDa, 5033417D07Rik, BTF2, D5Ertd679e
  • Feature Type
    protein coding gene
  • IDs
    MGI:1277143
    NCBI Gene: 209357
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:124717211-124735743 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 63.67 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    662 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1277143
 protein coding gene Chr5:124717203-124735743 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030102
 protein coding gene Chr5:128411392-128431632 (+)
A/J MGP_AJ_G0030067
 protein coding gene Chr5:123052552-123074107 (+)
AKR/J MGP_AKRJ_G0030003
 protein coding gene Chr5:127025103-127043329 (+)
BALB/cJ MGP_BALBcJ_G0030078
 protein coding gene Chr5:124391944-124411683 (+)
C3H/HeJ MGP_C3HHeJ_G0029795
 protein coding gene Chr5:127636173-127655976 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030531
 protein coding gene Chr5:133395725-133415489 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027757
 protein coding gene Chr5:117592277-117609354 (+)
CAST/EiJ MGP_CASTEiJ_G0029204
 protein coding gene Chr5:126752137-126773652 (+)
CBA/J MGP_CBAJ_G0029765
 protein coding gene Chr5:138614024-138633859 (+)
DBA/2J MGP_DBA2J_G0029915
 protein coding gene Chr5:123074801-123092834 (+)
FVB/NJ MGP_FVBNJ_G0029871
 protein coding gene Chr5:122121223-122140172 (+)
LP/J MGP_LPJ_G0030004
 protein coding gene Chr5:128945903-128964063 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029902
 protein coding gene Chr5:142182040-142201430 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030572
 protein coding gene Chr5:126645626-126663733 (+)
PWK/PhJ MGP_PWKPhJ_G0028918
 protein coding gene Chr5:121898740-121917656 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028755
 protein coding gene Chr5:124273025-124297445 (+)
WSB/EiJ MGP_WSBEiJ_G0029278
 protein coding gene Chr5:127330042-127350560 (+)



Homology
more
  • Human Ortholog
    GTF2H3, general transcription factor IIH subunit 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GTF2H3, general transcription factor IIH subunit 3
  • Synonyms
    BTF2, P34, TFB4, TFIIH
  • Links
    NCBI Gene ID: 2967
    neXtProt AC: NX_Q13889
    UniProt: Q13889

  • Chr Location
    12q24.31; chr12:123633739-123662604 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    21
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    744
  • Tissues
    20
  • cDNA Data
    56
  • Literature Summary
    5
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 209357 NCBI Gene Model | MGI Sequence Detail 18533 C57BL/6J ±  kb
transcript NM_181410 RefSeq | MGI Sequence Detail 2664 ZRU/MplStud  
polypeptide Q8VD76 UniProt | EBI | MGI Sequence Detail 309 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000008319 general transcription factor IIH subunit 3
    (term hierarchy)
  • InterPro Domains
    IPR004600 TFIIH subunit Tfb4/GTF2H3
    IPR036465 von Willebrand factor A-like domain superfamily
  • GlyGen
    Q8VD76 1 site, 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 59
    cDNA 56
    Primer pair 2
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGI:1923218
References
more
  • Summaries
    All 53
    Developmental Gene Expression 5
    Gene Ontology 6
    Phenotypes 15
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory