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Snca Gene Detail
Summary
  • Symbol
    Snca
  • Name
    synuclein, alpha
  • Synonyms
    alpha-Syn, alphaSYN, alpha-synuclein
  • Feature Type
    protein coding gene
  • IDs
    MGI:1277151
    NCBI Gene: 20617
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:60708559-60806839 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 29.15 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2912 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    3
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1277151
 protein coding gene Chr6:60708557-60806839 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030823
 protein coding gene Chr6:60468604-60569117 (-)
A/J MGP_AJ_G0030790
 protein coding gene Chr6:57815070-57921601 (-)
AKR/J MGP_AKRJ_G0030718
 protein coding gene Chr6:59744520-59848939 (-)
BALB/cJ MGP_BALBcJ_G0030802
 protein coding gene Chr6:58228884-58324629 (-)
C3H/HeJ MGP_C3HHeJ_G0030516
 protein coding gene Chr6:59774945-59876211 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031260
 protein coding gene Chr6:61848545-61951924 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028452
 protein coding gene Chr6:55390206-55479295 (-)
CAST/EiJ MGP_CASTEiJ_G0029914
 protein coding gene Chr6:59855035-59955970 (-)
CBA/J MGP_CBAJ_G0030489
 protein coding gene Chr6:64397016-64494563 (-)
DBA/2J MGP_DBA2J_G0030640
 protein coding gene Chr6:57546009-57644780 (-)
FVB/NJ MGP_FVBNJ_G0030593
 protein coding gene Chr6:57103226-57202391 (-)
LP/J MGP_LPJ_G0030725
 protein coding gene Chr6:60426407-60530333 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030628
 protein coding gene Chr6:67309384-67427213 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031286
 protein coding gene Chr6:59640825-59741500 (-)
PWK/PhJ MGP_PWKPhJ_G0029629
 protein coding gene Chr6:56719432-56816414 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029457
 protein coding gene Chr6:59118842-59217965 (-)
WSB/EiJ MGP_WSBEiJ_G0029996
 protein coding gene Chr6:59924990-60032276 (-)



Homology
more
  • Human Ortholog
    SNCA, synuclein alpha
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SNCA, synuclein alpha
  • Synonyms
    NACP, PARK1, PARK4, PD1
  • Links
    NCBI Gene ID: 6622
    neXtProt AC: NX_P37840
    UniProt: P37840

  • Chr Location
    4q22.1; chr4:89700345-89838315 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with Snca mouse models; 5 with human SNCA associations

Human Disease Mouse Models
      
IDs
 View 6 models
IDs
 View 1 model
      
IDs
IDs
 View 1 model
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    4 with disease annotations
  • References
    8 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    44 phenotypes from 10 alleles in 9 genetic backgrounds
    54 phenotypes from multigenic genotypes
    218 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display resistance to the effects of MPTP on dopamine levels. Mice expressing a knock-in allele exhibit impaired coordination, long stride length, abnormal response to reserpine and reduced brain dopamine levels.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    231
  • GO References
    48
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1017
  • Tissues
    236
  • cDNA Data
    44
  • Literature Summary
    37
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000025889 Ensembl Gene Model | MGI Sequence Detail 98281 C57BL/6J ±  kb
    transcript ENSMUST00000163779 Ensembl | MGI Sequence Detail 1188 Not Applicable  
    polypeptide ENSMUSP00000126067 Ensembl | MGI Sequence Detail 140 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 50
      cDNA 45
      Primer pair 3
      Other 2

      Microarray probesets 4
    References
    more
    • Summaries
      All 470
      Developmental Gene Expression 37
      Diseases 8
      Gene Ontology 48
      Phenotypes 218
    • Earliest
      J:48620 Hsu LJ, et al., Expression pattern of synucleins (non-Abeta component of Alzheimer's disease amyloid precursor protein/alpha-synuclein) during murine brain development. J Neurochem. 1998 Jul;71(1):338-44
    • Latest
      J:354987 Kim Y, et al., Olfactory deficit and gastrointestinal dysfunction precede motor abnormalities in alpha-Synuclein G51D knock-in mice. Proc Natl Acad Sci U S A. 2024 Sep 24;121(39):e2406479121
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory