Fam91a1 MGI Mouse Gene Detail - MGI:1277178 - family with sequence similarity 91, member A1

Symbol

Fam91a1
Name

family with sequence similarity 91, member A1
Synonyms

D15Ertd621e, mKIAA0493

Feature Type

protein coding gene
IDs

MGI:1277178
NCBI Gene: 210998
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr15:58287317-58329589 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 24.76 cM
Mapping Data

3 experiments

SNPs within 2kb

794 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1277178	protein coding gene	Chr15:58277868-58329655 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0021873	protein coding gene	Chr15:57601890-57641815 (+)
A/J	MGP_AJ_G0021833	protein coding gene	Chr15:55350535-55390021 (+)
AKR/J	MGP_AKRJ_G0021814	protein coding gene	Chr15:56878460-56917903 (+)
BALB/cJ	MGP_BALBcJ_G0021840	protein coding gene	Chr15:55564689-55608089 (+)
C3H/HeJ	MGP_C3HHeJ_G0021614	protein coding gene	Chr15:56996592-57039647 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0022279	protein coding gene	Chr15:59837229-59878077 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019816	protein coding gene	Chr15:52439991-52479470 (+)
CAST/EiJ	MGP_CASTEiJ_G0021131	protein coding gene	Chr15:57651596-57693996 (+)
CBA/J	MGP_CBAJ_G0021583	protein coding gene	Chr15:61907003-61949942 (+)
DBA/2J	MGP_DBA2J_G0021707	protein coding gene	Chr15:55266617-55306459 (+)
FVB/NJ	MGP_FVBNJ_G0021685	protein coding gene	Chr15:54318638-54358690 (+)
LP/J	MGP_LPJ_G0021777	protein coding gene	Chr15:57461357-57505242 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021709	protein coding gene	Chr15:66986819-67029934 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022302	protein coding gene	Chr15:57285848-57328272 (+)
PWK/PhJ	MGP_PWKPhJ_G0020876	protein coding gene	Chr15:55268467-55310282 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0020713	protein coding gene	Chr15:57067002-57110826 (+)
WSB/EiJ	MGP_WSBEiJ_G0021186	protein coding gene	Chr15:57277071-57319482 (+)

Human Ortholog

FAM91A1, family with sequence similarity 91 member A1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FAM91A1, family with sequence similarity 91 member A1
Links

HGNC:26306

NCBI Gene ID: 157769

neXtProt AC: NX_Q658Y4

UniProt: Q658Y4
Chr Location

8q24.13; chr8:123768439-123815452 (+) GRCh38

MGI Vertebrate Homology

Fam91a1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: FAM91A1
Gene Tree

Fam91a1

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References

1 with disease annotations

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Phenotype Summary

7 phenotypes from 2 alleles in 2 genetic backgrounds
30 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

13
Chemically induced (other)

3
Endonuclease-mediated

2
Gene trapped

5
Radiation induced

2
Transgenic

1
Genomic Mutations

5 involving Fam91a1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

27 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a transgenic gene disruption exhibit male infertility.

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All GO Annotations

12
GO References

4

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

822
Tissues

21
cDNA Data

12
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase fam91a1

ZFIN fam91a1

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All Sequences

51
RefSeq

8
UniProt

2
CCDS

CCDS37080.1

Ensembl

ENSMUSG00000037119 (Evidence)
NCBI Gene

210998

			Length	Strain/Species	Flank
genomic	ENSMUSG00000037119	Ensembl Gene Model \| MGI Sequence Detail	42273	C57BL/6J	± kb
transcript	ENSMUST00000037270	Ensembl \| MGI Sequence Detail	5560	Not Applicable
polypeptide	ENSMUSP00000036524	Ensembl \| MGI Sequence Detail	837	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000029470 protein FAM91A1

(term hierarchy)
InterPro Domains

IPR039199 FAM91

IPR028097 FAM91, C-terminal domain

IPR028091 FAM91, N-terminal domain
GlyGen

Q3UVG3 1 site, 1 O-linked glycan (1 site)

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All nucleic 13

cDNA 12

Primer pair 1

Microarray probesets 5

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MGI:2146170, MGI:2384813

Summaries

All 59

Developmental Gene Expression 1

Diseases 1

Gene Ontology 4

Phenotypes 30
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:285676 Suzuki A, et al., Genes and microRNAs associated with mouse cleft palate: A systematic review and bioinformatics analysis. Mech Dev. 2018 Apr;150:21-27

TSS for Fam91a1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr131338	Chr15:58287305-58287361 (+)	16 bp
Tssr131339	Chr15:58287370-58287383 (+)	60 bp
Tssr131340	Chr15:58304600-58304610 (+)	17,288 bp
Tssr131341	Chr15:58321510-58321522 (+)	34,199 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/05/2024 MGI 6.24