Cxcr3 MGI Mouse Gene Detail - MGI:1277207 - C-X-C motif chemokine receptor 3

Symbol

Cxcr3
Name

C-X-C motif chemokine receptor 3
Synonyms

Cd183, Cmkar3, Cxcr3

Feature Type

protein coding gene
IDs

MGI:1277207
NCBI Gene: 12766
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

ChrX:100775141-100777753 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome X, 44.58 cM
Mapping Data

2 experiments

SNPs within 2kb

80 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1277207	protein coding gene	ChrX:100775141-100777875 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0035965	protein coding gene	ChrX:98273825-98276556 (-)
A/J	MGP_AJ_G0035950	protein coding gene	ChrX:98252052-98254786 (-)
AKR/J	MGP_AKRJ_G0035866	protein coding gene	ChrX:101088820-101091552 (-)
BALB/cJ	MGP_BALBcJ_G0035933	protein coding gene	ChrX:96998533-97001267 (-)
C3H/HeJ	MGP_C3HHeJ_G0035642	protein coding gene	ChrX:98672925-98675659 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0036463	protein coding gene	ChrX:101179434-101183026 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0033292	protein coding gene	ChrX:95982071-95984803 (-)
CAST/EiJ	MGP_CASTEiJ_G0034929	protein coding gene	ChrX:82964718-82967452 (-)
CBA/J	MGP_CBAJ_G0035617	protein coding gene	ChrX:104320667-104323398 (-)
DBA/2J	MGP_DBA2J_G0035771	protein coding gene	ChrX:97462151-97465094 (-)
FVB/NJ	MGP_FVBNJ_G0035710	protein coding gene	ChrX:96846474-96849205 (-)
LP/J	MGP_LPJ_G0035862	protein coding gene	ChrX:99209455-99212202 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0035744	protein coding gene	ChrX:108855028-108857762 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0036489	protein coding gene	ChrX:97943376-97946888 (-)
PWK/PhJ	MGP_PWKPhJ_G0034628	protein coding gene	ChrX:80567674-80570407 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0034456	protein coding gene	ChrX:83887608-83890339 (-)
WSB/EiJ	MGP_WSBEiJ_G0035068	protein coding gene	ChrX:96649801-96652534 (-)

Human Ortholog

CXCR3, C-X-C motif chemokine receptor 3

Vertebrate Orthologs

5

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CXCR3, C-X-C motif chemokine receptor 3
Synonyms

CD182, CD183, CKR-L2, CMKAR3, GPR9, IP10-R, Mig-R, MigR
Links

HGNC:4540

NCBI Gene ID: 2833

neXtProt AC: NX_P49682

UniProt: P49682
Chr Location

Xq13.1; chrX:71615916-71618511 (-) GRCh38

MGI Vertebrate Homology

Cxcr3 stringent orthology
1 human;1 mouse;1 rat;3 zebrafish
HCOP

vertebrate homology predictions: CXCR3
Gene Tree

Cxcr3

Diseases

1 with human CXCR3 associations

				Human Disease	Mouse Models
				asthma IDs asthma DOID:2841 DOID:12703 DOID:13829 DOID:13830 DOID:2840 DOID:5783 ICD10CM:J45 ICD9CM:493 ICD9CM:493.9 KEGG:05310 MESH:D001249 NCI:C28397 OMIM:600807 UMLS_CUI:C0004096

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

17 phenotypes from 4 alleles in 5 genetic backgrounds
1 phenotype from multigenic genotypes
204 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

18
Endonuclease-mediated

8
Targeted

9
Transgenic

1
Find Mice (IMSR)

14 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous or hemizygous for disruptions in this gene display immune system abnormalities. Hemizygous male mice exhibit elevated serum glucose levels.

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All GO Annotations

48
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

806
Tissues

51
cDNA Data

7
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cxcr3

ZFIN cxcr3.1, cxcr3.2

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All Sequences

29
RefSeq

2
UniProt

1
CCDS

CCDS30319.1

Ensembl

ENSMUSG00000050232 (Evidence)
NCBI Gene

12766

			Length	Strain/Species	Flank
genomic	12766	NCBI Gene Model \| MGI Sequence Detail	2613	C57BL/6J	± kb
transcript	NM_009910	RefSeq \| MGI Sequence Detail	1609	ZRU/MplStud
polypeptide	O88410	UniProt \| EBI \| MGI Sequence Detail	367	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000001207 C-X-C chemokine receptor type 3

(term hierarchy)
InterPro Domains

IPR000355 Chemokine receptor family

IPR004070 CXC chemokine receptor 3

IPR017452 GPCR, rhodopsin-like, 7TM

IPR050119 G-protein coupled receptor 1

IPR000276 G protein-coupled receptor, rhodopsin-like
GlyGen

O88410 2 sites

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All nucleic 10

Genomic 1

cDNA 7

Primer pair 2

Microarray probesets 3

Summaries

All 285

Developmental Gene Expression 6

Gene Ontology 10

Phenotypes 204
Earliest

J:48732 Soto H, et al., The CC chemokine 6Ckine binds the CXC chemokine receptor CXCR3. Proc Natl Acad Sci U S A. 1998 Jul 7;95(14):8205-10
Latest

J:352246 Guo K, et al., The chemokine receptor CXCR3 promotes CD8(+) T cell-dependent lung pathology during influenza pathogenesis. Sci Adv. 2024 Jan 5;10(1):eadj1120

TSS for Cxcr3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr163894	ChrX:100777806-100777817 (-)	-59 bp
Tssr163893	ChrX:100777763-100777774 (-)	-16 bp
Tssr163892	ChrX:100777731-100777748 (-)	13 bp
Tssr163891	ChrX:100777716-100777729 (-)	30 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24