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Tyrobp Gene Detail
Summary
  • Symbol
    Tyrobp
  • Name
    TYRO protein tyrosine kinase binding protein
  • Synonyms
    DAP12, KARAP, killer cell activating receptor associated protein
  • Feature Type
    protein coding gene
  • IDs
    MGI:1277211
    NCBI Gene: 22177
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:30113207-30117007 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 17.45 cM, cytoband B
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    189 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1277211
 protein coding gene Chr7:30113185-30117010 (+)
129S1/SvImJ MGP_129S1SvImJ_G0032017
 protein coding gene Chr7:29399748-29403516 (+)
A/J MGP_AJ_G0031994
 protein coding gene Chr7:28617698-28621494 (+)
AKR/J MGP_AKRJ_G0031927
 protein coding gene Chr7:29348204-29351983 (+)
BALB/cJ MGP_BALBcJ_G0032001
 protein coding gene Chr7:28796083-28799919 (+)
C3H/HeJ MGP_C3HHeJ_G0031720
 protein coding gene Chr7:29793108-29796877 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032467
 protein coding gene Chr7:30359575-30363785 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029517
 protein coding gene Chr7:29652706-29656279 (+)
CAST/EiJ MGP_CASTEiJ_G0031054
 protein coding gene Chr7:23050089-23053847 (+)
CBA/J MGP_CBAJ_G0031686
 protein coding gene Chr7:31807627-31811388 (+)
DBA/2J MGP_DBA2J_G0031838
 protein coding gene Chr7:28347507-28351221 (+)
FVB/NJ MGP_FVBNJ_G0031795
 protein coding gene Chr7:28466981-28470736 (+)
LP/J MGP_LPJ_G0031919
 protein coding gene Chr7:29720343-29724111 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031831
 protein coding gene Chr7:31056586-31062751 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032495
 protein coding gene Chr7:28846767-28850698 (+)
PWK/PhJ MGP_PWKPhJ_G0030780
 protein coding gene Chr7:23384592-23388560 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030613
 protein coding gene Chr7:19853439-19857471 (+)
WSB/EiJ MGP_WSBEiJ_G0031164
 protein coding gene Chr7:29231603-29235530 (+)



Homology
more
  • Human Ortholog
    TYROBP, transmembrane immune signaling adaptor TYROBP
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TYROBP, transmembrane immune signaling adaptor TYROBP
  • Synonyms
    DAP12, KARAP, PLOSL, PLOSL1
  • Links
    NCBI Gene ID: 7305
    neXtProt AC: NX_O43914
    UniProt: O43914

  • Chr Location
    19q13.12; chr19:35904401-35908295 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Tyrobp mouse models; 1 with human TYROBP associations

Human Disease Mouse Models
      
IDs
 View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    59 phenotypes from 4 alleles in 7 genetic backgrounds
    29 phenotypes from multigenic genotypes
    2 images
    133 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit osteopetrosis, hypomyelination (especially of the thalamus), synaptic degeneration, and impaired oligodendrocyte, NK, and dendritic cell function.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    73
  • GO References
    25
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    725
  • Tissues
    11
  • cDNA Data
    21
  • Literature Summary
    10
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 22177 NCBI Gene Model | MGI Sequence Detail 3801 C57BL/6J ±  kb
    transcript NM_011662 RefSeq | MGI Sequence Detail 592 ZRU/MplStud  
    polypeptide O54885 UniProt | EBI | MGI Sequence Detail 114 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 24
      Genomic 1
      cDNA 21
      Other 2

      Microarray probesets 3
    References
    more
    • Summaries
      All 195
      Developmental Gene Expression 10
      Diseases 2
      Gene Ontology 25
      Phenotypes 133
    • Earliest
      J:49202 Lanier LL, et al., Immunoreceptor DAP12 bearing a tyrosine-based activation motif is involved in activating NK cells [see comments]. Nature. 1998 Feb 12;391(6668):703-7
    • Latest
      J:349614 Creus-Muncunill J, et al., TYROBP/DAP12 knockout in Huntington's disease Q175 mice cell-autonomously decreases microglial expression of disease-associated genes and non-cell-autonomously mitigates astrogliosis and motor deterioration. J Neuroinflammation. 2024 Mar 8;21(1):66
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory