Dach1 MGI Mouse Gene Detail - MGI:1277991 - dachshund family transcription factor 1

Symbol

Dach1
Name

dachshund family transcription factor 1
Synonyms

D6, Dac, E130112M23Rik

Feature Type

protein coding gene
IDs

MGI:1277991
NCBI Gene: 13134
Alliance

gene page
Transcription Start Sites

15 TSS

Sequence Map

Chr14:98024289-98407201 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 48.25 cM, cytoband E3
Mapping Data

5 experiments

SNPs within 2kb

9698 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1277991	protein coding gene	Chr14:98024289-98407208 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0021613	protein coding gene	Chr14:94008188-94413665 (-)
A/J	MGP_AJ_G0021571	protein coding gene	Chr14:91050995-91436197 (-)
AKR/J	MGP_AKRJ_G0021547	protein coding gene	Chr14:93685812-94079498 (-)
BALB/cJ	MGP_BALBcJ_G0021577	protein coding gene	Chr14:91321389-91705472 (-)
C3H/HeJ	MGP_C3HHeJ_G0021355	protein coding gene	Chr14:93595742-93984179 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0022017	protein coding gene	Chr14:97837457-98236460 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019557	protein coding gene	Chr14:88111804-88494753 (-)
CAST/EiJ	MGP_CASTEiJ_G0020872	protein coding gene	Chr14:90852932-91268960 (-)
CBA/J	MGP_CBAJ_G0021323	protein coding gene	Chr14:101446135-101888063 (-)
DBA/2J	MGP_DBA2J_G0021447	protein coding gene	Chr14:90507795-90901269 (-)
FVB/NJ	MGP_FVBNJ_G0021423	protein coding gene	Chr14:89514299-89928757 (-)
LP/J	MGP_LPJ_G0021515	protein coding gene	Chr14:94792658-95214900 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021451	protein coding gene	Chr14:104071452-104605031 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022040	protein coding gene	Chr14:93221744-93623005 (-)
PWK/PhJ	MGP_PWKPhJ_G0020615	protein coding gene	Chr14:87466004-87859960 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0020453	protein coding gene	Chr14:89145406-89555608 (-)
WSB/EiJ	MGP_WSBEiJ_G0020925	protein coding gene	Chr14:93773047-94180190 (-)

Human Ortholog

DACH1, dachshund family transcription factor 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DACH1, dachshund family transcription factor 1
Synonyms

DACH
Links

HGNC:2663

NCBI Gene ID: 1602

neXtProt AC: NX_Q9UI36

UniProt: Q9UI36
Chr Location

13q21.33; chr13:71437966-71867204 (-) GRCh38

MGI Vertebrate Homology

Dach1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: DACH1
Gene Tree

Dach1

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Phenotype Summary

14 phenotypes from 3 alleles in 4 genetic backgrounds
27 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

15
Chemically induced (other)

1
Endonuclease-mediated

4
Targeted

10
Genomic Mutations

1 involving Dach1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

51 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

In spite of normal gross morphology, mice homozygous for targeted mutations that inactivate this gene die within 1 day of birth.

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All GO Annotations

51
GO References

14

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1603
Tissues

342
cDNA Data

38
Literature Summary

47

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA DACH1

Xenbase dach1

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All Sequences

52
RefSeq

6
UniProt

4
CCDS

CCDS36993.1, CCDS36994.1

Ensembl

ENSMUSG00000055639 (Evidence)
NCBI Gene

13134

			Length	Strain/Species	Flank
genomic	ENSMUSG00000055639	Ensembl Gene Model \| MGI Sequence Detail	382913	C57BL/6J	± kb
transcript	ENSMUST00000071533	Ensembl \| MGI Sequence Detail	5219	Not Applicable
polypeptide	ENSMUSP00000071464	Ensembl \| MGI Sequence Detail	751	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000006261 dachshund homolog 1

(term hierarchy)
InterPro Domains

IPR052417 Dachshund domain-containing protein

IPR009061 Putative DNA-binding domain superfamily

IPR037000 Ski-like, DNA-binding domain superfamily

IPR003380 SKI/SNO/DAC domain

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All nucleic 48

Genomic 2

cDNA 38

Primer pair 3

Other 5

Microarray probesets 7

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MGI:2145601, MGI:2442731

Summaries

All 99

Developmental Gene Expression 47

Gene Ontology 14

Phenotypes 27
Earliest

J:38305 Stewart GJ, et al., Sequence analysis of 497 mouse brain ESTs expressed in the substantia nigra. Genomics. 1997 Jan 15;39(2):147-53
Latest

J:350367 Tanaka K, et al., Dach1 is essential for maintaining normal mature podocytes. PLoS One. 2024;19(5):e0303910

TSS for Dach1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr129997	Chr14:98407247-98407276 (-)	-61 bp
Tssr129996	Chr14:98407188-98407242 (-)	-14 bp
Tssr129995	Chr14:98407039-98407054 (-)	154 bp
Tssr129994	Chr14:98406978-98407031 (-)	196 bp
Tssr129993	Chr14:98406900-98406915 (-)	293 bp
Tssr129992	Chr14:98406749-98406778 (-)	437 bp
Tssr129991	Chr14:98406719-98406733 (-)	475 bp
Tssr129990	Chr14:98406644-98406699 (-)	529 bp
Tssr129989	Chr14:98406527-98406538 (-)	668 bp
Tssr129988	Chr14:98397216-98397231 (-)	9,977 bp
Tssr129987	Chr14:98347491-98347501 (-)	59,705 bp
Tssr4504	Chr14:98347464-98347473 (-)	59,732 bp
Tssr129986	Chr14:98342347-98342350 (-)	64,852 bp
Tssr129985	Chr14:98342006-98342014 (-)	65,191 bp
Tssr129984	Chr14:98306038-98306041 (-)	101,161 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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