About   Help   FAQ
Epc1 Gene Detail
Summary
  • Symbol
    Epc1
  • Name
    enhancer of polycomb homolog 1
  • Synonyms
    2400007E14Rik, 5730566F07Rik, A930032N02Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1278322
    NCBI Gene: 13831
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:6435951-6516108 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 4.48 cM, cytoband A1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1718 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1278322
 protein coding gene Chr18:6435951-6516108 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024130
 protein coding gene Chr18:3303416-3387429 (-)
A/J MGP_AJ_G0024092
 protein coding gene Chr18:3319164-3400055 (-)
AKR/J MGP_AKRJ_G0024060
 protein coding gene Chr18:3396903-3491274 (-)
BALB/cJ MGP_BALBcJ_G0024092
 protein coding gene Chr18:3289419-3373247 (-)
C3H/HeJ MGP_C3HHeJ_G0023858
 protein coding gene Chr18:3308920-3393859 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024537
 protein coding gene Chr18:3546708-3627805 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021976
 protein coding gene Chr18:3068453-3149884 (-)
CAST/EiJ MGP_CASTEiJ_G0023336
 protein coding gene Chr18:3337908-3417090 (-)
CBA/J MGP_CBAJ_G0023831
 protein coding gene Chr18:3465612-3549498 (-)
DBA/2J MGP_DBA2J_G0023959
 protein coding gene Chr18:3204929-3285132 (-)
FVB/NJ MGP_FVBNJ_G0023925
 protein coding gene Chr18:3204276-3285559 (-)
LP/J MGP_LPJ_G0024043
 protein coding gene Chr18:3336621-3419845 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023953
 protein coding gene Chr18:3558151-3644131 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024582
 protein coding gene Chr18:3276856-3357412 (-)
PWK/PhJ MGP_PWKPhJ_G0023081
 protein coding gene Chr18:3239629-3319447 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022892
 protein coding gene Chr18:3552420-3637510 (-)
WSB/EiJ MGP_WSBEiJ_G0023402
 protein coding gene Chr18:3303733-3385086 (-)



Homology
more
  • Human Ortholog
    EPC1, enhancer of polycomb homolog 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    EPC1, enhancer of polycomb homolog 1
  • Synonyms
    Epl1
  • Links
    NCBI Gene ID: 80314
    neXtProt AC: NX_Q9H2F5
    UniProt: Q9H2F5

  • Chr Location
    10p11.22; chr10:32267751-32378798 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 2 alleles in 2 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap allele die prior to P10 (no time point given) and heterozygous mice exhibit impaired skeletal muscle differentiation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    42
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    863
  • Tissues
    133
  • cDNA Data
    55
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 13831 NCBI Gene Model | MGI Sequence Detail 80158 C57BL/6J ±  kb
    transcript NM_027497 RefSeq | MGI Sequence Detail 3983 C57BL/6  
    polypeptide Q8C9X6 UniProt | EBI | MGI Sequence Detail 813 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 60
      cDNA 58
      Primer pair 1
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1916980, MGI:1917905, MGI:1924445
    References
    more
    • Summaries
      All 51
      Developmental Gene Expression 6
      Gene Ontology 10
      Phenotypes 14
    • Earliest
      J:43737 Stankunas K, et al., The enhancer of polycomb gene of Drosophila encodes a chromatin protein conserved in yeast and mammals. Development. 1998 Oct;125(20):4055-66
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory