Dnpep MGI Mouse Gene Detail - MGI:1278328

Symbol

Dnpep
Name

aspartyl aminopeptidase

Feature Type

protein coding gene
IDs

MGI:1278328
NCBI Gene: 13437
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr1:75285209-75294648 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 38.71 cM
Mapping Data

2 experiments

SNPs within 2kb

343 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1278328	protein coding gene	Chr1:75284540-75294648 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0016184	protein coding gene	Chr1:75874197-75884295 (-)
A/J	MGP_AJ_G0016167	protein coding gene	Chr1:73230601-73240696 (-)
AKR/J	MGP_AKRJ_G0016124	protein coding gene	Chr1:75261015-75271114 (-)
BALB/cJ	MGP_BALBcJ_G0016122	protein coding gene	Chr1:73291968-73302062 (-)
C3H/HeJ	MGP_C3HHeJ_G0015953	protein coding gene	Chr1:75596962-75607057 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0016575	protein coding gene	Chr1:78827059-78837109 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014296	protein coding gene	Chr1:68793116-68803511 (-)
CAST/EiJ	MGP_CASTEiJ_G0015537	protein coding gene	Chr1:74939915-74950038 (-)
CBA/J	MGP_CBAJ_G0015926	protein coding gene	Chr1:81389792-81399887 (-)
DBA/2J	MGP_DBA2J_G0016027	protein coding gene	Chr1:72548856-72558954 (-)
FVB/NJ	MGP_FVBNJ_G0016030	protein coding gene	Chr1:71752138-71762236 (-)
LP/J	MGP_LPJ_G0016099	protein coding gene	Chr1:76999419-77009517 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016050	protein coding gene	Chr1:84739628-84749925 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016622	protein coding gene	Chr1:75330621-75340719 (-)
PWK/PhJ	MGP_PWKPhJ_G0015324	protein coding gene	Chr1:72023009-72033080 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0015102	protein coding gene	Chr1:74697746-74707835 (-)
WSB/EiJ	MGP_WSBEiJ_G0015599	protein coding gene	Chr1:75144131-75154230 (-)

Human Ortholog

DNPEP, aspartyl aminopeptidase

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DNPEP, aspartyl aminopeptidase
Synonyms

ASPEP, DAP
Links

HGNC:2981

NCBI Gene ID: 23549

neXtProt AC: NX_Q9ULA0

UniProt: Q9ULA0
Chr Location

2q35; chr2:219372029-219400022 (-) GRCh38

MGI Vertebrate Homology

Dnpep stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: DNPEP
Gene Tree

Dnpep

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References

1 with disease annotations

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Phenotype Summary

3 phenotypes from 2 alleles in 2 genetic backgrounds
29 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

1
Radiation induced

2
Spontaneous

1
Targeted

2
Genomic Mutations

4 involving Dnpep
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

35 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele are viable and overtly normal.

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All GO Annotations

8
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

181
Literature Summary

2

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase dnpep

ZFIN dnpep

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All Sequences

100
RefSeq

24
UniProt

10
CCDS

CCDS15070.1, CCDS78623.1

Ensembl

ENSMUSG00000026209 (Evidence)
NCBI Gene

13437

			Length	Strain/Species	Flank
genomic	13437	NCBI Gene Model \| MGI Sequence Detail	9440	C57BL/6J	± kb
transcript	NM_001420137	RefSeq \| MGI Sequence Detail	1884	C57BL/6
polypeptide	Q9Z2W0	UniProt \| EBI \| MGI Sequence Detail	473	Not Applicable

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UniProt

10 Sequences
Protein Ontology

PR:000006610 aspartyl aminopeptidase

(term hierarchy)
EC

3.4.11.21
InterPro Domains

IPR001948 Peptidase M18

IPR023358 Peptidase M18, domain 2

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All nucleic 183

cDNA 183

Microarray probesets 7

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MGI:2138076

Summaries

All 58

Developmental Gene Expression 2

Diseases 1

Gene Ontology 5

Phenotypes 29
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Dnpep:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr12397	Chr1:75294234-75294256 (-)	403 bp
Tssr12396	Chr1:75294180-75294189 (-)	463 bp
Tssr12395	Chr1:75294004-75294135 (-)	578 bp
Tssr12394	Chr1:75293943-75293986 (-)	683 bp
Tssr12393	Chr1:75293807-75293821 (-)	834 bp
Tssr12392	Chr1:75293642-75293669 (-)	992 bp
Tssr12391	Chr1:75293590-75293626 (-)	1,040 bp
Tssr12390	Chr1:75293558-75293581 (-)	1,078 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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