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Dgkz Gene Detail
Summary
  • Symbol
    Dgkz
  • Name
    diacylglycerol kinase zeta
  • Synonyms
    E130307B02Rik, mDGK[z]
  • Feature Type
    protein coding gene
  • IDs
    MGI:1278339
    NCBI Gene: 104418
  • Alliance
    gene page
  • Transcription Start Sites
    16 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:91763169-91806209 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 50.63 cM, cytoband E1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    938 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1278339
 protein coding gene Chr2:91763167-91806788 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026160
 protein coding gene Chr2:93316609-93364714 (-)
A/J MGP_AJ_G0026121
 protein coding gene Chr2:89558014-89601698 (-)
AKR/J MGP_AKRJ_G0026102
 protein coding gene Chr2:92031681-92076816 (-)
BALB/cJ MGP_BALBcJ_G0026130
 protein coding gene Chr2:89744064-89787496 (-)
C3H/HeJ MGP_C3HHeJ_G0025881
 protein coding gene Chr2:92331709-92380615 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026581
 protein coding gene Chr2:96545008-96591419 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023972
 protein coding gene Chr2:86051919-86094503 (-)
CAST/EiJ MGP_CASTEiJ_G0025346
 protein coding gene Chr2:92871911-92917223 (-)
CBA/J MGP_CBAJ_G0025859
 protein coding gene Chr2:99884506-99927356 (-)
DBA/2J MGP_DBA2J_G0025995
 protein coding gene Chr2:89154722-89197714 (-)
FVB/NJ MGP_FVBNJ_G0025958
 protein coding gene Chr2:88252439-88305798 (-)
LP/J MGP_LPJ_G0026099
 protein coding gene Chr2:93514252-93563736 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025984
 protein coding gene Chr2:102881753-102928742 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026635
 protein coding gene Chr2:92117456-92162307 (-)
PWK/PhJ MGP_PWKPhJ_G0025081
 protein coding gene Chr2:88891338-88935888 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024882
 protein coding gene Chr2:91678294-91724972 (-)
WSB/EiJ MGP_WSBEiJ_G0025413
 protein coding gene Chr2:92720837-92769778 (-)



Homology
more
  • Human Ortholog
    DGKZ, diacylglycerol kinase zeta
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DGKZ, diacylglycerol kinase zeta
  • Synonyms
    DAGK5, DAGK6, DGK-ZETA, hDGKzeta
  • Links
    NCBI Gene ID: 8525
    neXtProt AC: NX_Q13574
    UniProt: Q13574

  • Chr Location
    11p11.2; chr11:46332905-46380554 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotypes from 1 allele in 2 genetic backgrounds
    2 phenotypes from multigenic genotypes
    58 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
The T cell response is enhanced in homozygous mutant mice, which showed a robust response to viral infection.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    50
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    965
  • Tissues
    132
  • cDNA Data
    17
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000040479 Ensembl Gene Model | MGI Sequence Detail 43041 C57BL/6J ±  kb
    transcript ENSMUST00000111303 Ensembl | MGI Sequence Detail 4169 Not Applicable  
    polypeptide ENSMUSP00000106934 Ensembl | MGI Sequence Detail 1123 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      9 Sequences
    • Protein Ontology
      PR:000006451 diacylglycerol kinase zeta
      (term hierarchy)
    • EC
      2.7.1.107, 2.7.1.93
    • InterPro Domains
      IPR002110 Ankyrin repeat
      IPR036770 Ankyrin repeat-containing domain superfamily
      IPR046349 C1-like domain superfamily
      IPR037607 Diacylglycerol kinase
      IPR000756 Diacylglycerol kinase, accessory domain
      IPR001206 Diacylglycerol kinase, catalytic domain
      IPR047485 Diacylglycerol kinase zeta, first protein kinase C conserved region 1
      IPR047484 Diacylglycerol kinase zeta, second protein kinase C conserved region 1
      IPR017438 Inorganic polyphosphate/ATP-NAD kinase, N-terminal
      IPR016064 NAD kinase/diacylglycerol kinase-like domain superfamily
      IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
    Molecular
    Reagents
    less
    • All nucleic 21
      Genomic 1
      cDNA 18
      Primer pair 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2445090
    References
    more
    • Summaries
      All 100
      Developmental Gene Expression 5
      Gene Ontology 13
      Phenotypes 58
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:342887 Okumura M, et al., The diacylglycerol kinase zeta inhibitor ASP1570 augments natural killer cell function. Int Immunopharmacol. 2023 Dec;125(Pt A):111145
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory