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Trmt1 Gene Detail
Summary
  • Symbol
    Trmt1
  • Name
    tRNA methyltransferase 1
  • Synonyms
    6720406L13Rik, D8Ertd812e
  • Feature Type
    protein coding gene
  • IDs
    MGI:1289155
    NCBI Gene: 212528
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:85412953-85426437 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 41.02 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    278 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1289155
 protein coding gene Chr8:85412936-85426437 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033866
 protein coding gene Chr8:85597830-85612585 (+)
A/J MGP_AJ_G0033849
 protein coding gene Chr8:82227562-82242269 (+)
AKR/J MGP_AKRJ_G0033775
 protein coding gene Chr8:84662379-84676142 (+)
BALB/cJ MGP_BALBcJ_G0033842
 protein coding gene Chr8:82350678-82364921 (+)
C3H/HeJ MGP_C3HHeJ_G0033552
 protein coding gene Chr8:85278159-85297704 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034362
 protein coding gene Chr8:88885547-88904811 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031304
 protein coding gene Chr8:76021312-76034908 (+)
CAST/EiJ MGP_CASTEiJ_G0032882
 protein coding gene Chr8:84702451-84720797 (+)
CBA/J MGP_CBAJ_G0033528
 protein coding gene Chr8:91931514-91947709 (+)
DBA/2J MGP_DBA2J_G0033681
 protein coding gene Chr8:81868815-81883157 (+)
FVB/NJ MGP_FVBNJ_G0033629
 protein coding gene Chr8:80806032-80820210 (+)
LP/J MGP_LPJ_G0033773
 protein coding gene Chr8:85711141-85726940 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033671
 protein coding gene Chr8:94476113-94492916 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034379
 protein coding gene Chr8:84652517-84665941 (+)
PWK/PhJ MGP_PWKPhJ_G0032586
 protein coding gene Chr8:81111842-81125607 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032422
 protein coding gene Chr8:83462466-83476992 (+)
WSB/EiJ MGP_WSBEiJ_G0032995
 protein coding gene Chr8:85078397-85096721 (+)



Homology
more
  • Human Ortholog
    TRMT1, tRNA methyltransferase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TRMT1, tRNA methyltransferase 1
  • Synonyms
    MRT68, TRM1
  • Links
    NCBI Gene ID: 55621
    neXtProt AC: NX_Q9NXH9
    UniProt: Q9NXH9

  • Chr Location
    19p13.13; chr19:13104902-13117567 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human TRMT1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    44 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    120
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 212528 NCBI Gene Model | MGI Sequence Detail 13485 C57BL/6J ±  kb
    transcript NM_001364176 RefSeq | MGI Sequence Detail 2356 ZRU/MplStud  
    polypeptide Q3TX08 UniProt | EBI | MGI Sequence Detail 663 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      15 Sequences
    • Protein Ontology
      PR:000016677 N(2),N(2)-dimethylguanosine tRNA methyltransferase
      (term hierarchy)
    • EC
      2.1.1.216
    • InterPro Domains
      IPR029063 S-adenosyl-L-methionine-dependent methyltransferase superfamily
      IPR002905 tRNA methyltransferase, Trm1
      IPR042296 tRNA methyltransferase, Trm1, C-terminal
      IPR000571 Zinc finger, CCCH-type
      IPR036855 Zinc finger, CCCH-type superfamily
    • GlyGen
      Q3TX08 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 122
      cDNA 121
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1924395
    References
    more
    • Summaries
      All 72
      Gene Ontology 6
      Phenotypes 44
    • Earliest
      J:13049 Gruneberg H, Genetical studies on the skeleton of the mouse. XVIII. Three genes for syndactylism. J Genet. 1956;54(1):113-145
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory