Scyl2 MGI Mouse Gene Detail - MGI:1289172 - SCY1-like 2 (S. cerevisiae)

Symbol

Scyl2
Name

SCY1-like 2 (S. cerevisiae)
Synonyms

CVAK104, D10Ertd802e

Feature Type

protein coding gene
IDs

MGI:1289172
NCBI Gene: 213326
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr10:89474583-89522147 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 45.05 cM
Mapping Data

3 experiments

SNPs within 2kb

1315 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1289172	protein coding gene	Chr10:89474582-89522179 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0017638	protein coding gene	Chr10:90832747-90882863 (-)
A/J	MGP_AJ_G0017617	protein coding gene	Chr10:87728956-87776516 (-)
AKR/J	MGP_AKRJ_G0017575	protein coding gene	Chr10:90218813-90267316 (-)
BALB/cJ	MGP_BALBcJ_G0017580	protein coding gene	Chr10:87989182-88038327 (-)
C3H/HeJ	MGP_C3HHeJ_G0017403	protein coding gene	Chr10:90226495-90275923 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0018037	protein coding gene	Chr10:93870564-93926427 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015719	protein coding gene	Chr10:83438009-83486957 (-)
CAST/EiJ	MGP_CASTEiJ_G0016968	protein coding gene	Chr10:90146627-90199512 (-)
CBA/J	MGP_CBAJ_G0017372	protein coding gene	Chr10:97743398-97794604 (-)
DBA/2J	MGP_DBA2J_G0017478	protein coding gene	Chr10:86847672-86895879 (-)
FVB/NJ	MGP_FVBNJ_G0017470	protein coding gene	Chr10:86070371-86118486 (-)
LP/J	MGP_LPJ_G0017552	protein coding gene	Chr10:91472341-91522583 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017501	protein coding gene	Chr10:99224520-99277873 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018074	protein coding gene	Chr10:90105024-90157493 (-)
PWK/PhJ	MGP_PWKPhJ_G0016749	protein coding gene	Chr10:86876744-86926084 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0016537	protein coding gene	Chr10:88857954-88907074 (-)
WSB/EiJ	MGP_WSBEiJ_G0017027	protein coding gene	Chr10:90094196-90142558 (-)

Human Ortholog

SCYL2, SCY1 like pseudokinase 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SCYL2, SCY1 like pseudokinase 2
Synonyms

AMC4, AMCNACC, CVAK104
Links

HGNC:19286

NCBI Gene ID: 55681

neXtProt AC: NX_Q6P3W7

UniProt: Q6P3W7
Chr Location

12q23.1; chr12:100267140-100341715 (+) GRCh38

MGI Vertebrate Homology

Scyl2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SCYL2
Gene Tree

Scyl2

Diseases

1 with human SCYL2 associations

				Human Disease	Mouse Models
				arthrogryposis multiplex congenita-4 IDs arthrogryposis multiplex congenita-4 DOID:0080980 OMIM:618766

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

21 phenotypes from 2 alleles in 2 genetic backgrounds
4 phenotypes from multigenic genotypes
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Chemically induced (other)

1
Gene trapped

7
Targeted

5
Transposon induced

1
Genomic Mutations

2 involving Scyl2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

37 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit neonatal lethality, absent gastric milk in neonates, postnatal growth retardation, sensory-motor deficits and limb grapsing. Mice homozygous for a conditional allele exhibit similar phenotypes with near complete loss of CA3 neurons.

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All GO Annotations

18
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

64

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase scyl2

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All Sequences

64
RefSeq

10
UniProt

3
CCDS

CCDS36027.1, CCDS78881.1

Ensembl

ENSMUSG00000069539 (Evidence)
NCBI Gene

213326

			Length	Strain/Species	Flank
genomic	ENSMUSG00000069539	Ensembl Gene Model \| MGI Sequence Detail	47565	C57BL/6J	± kb
transcript	ENSMUST00000174252	Ensembl \| MGI Sequence Detail	4817	Not Applicable
polypeptide	ENSMUSP00000133992	Ensembl \| MGI Sequence Detail	930	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000014549 SCY1-like protein 2

(term hierarchy)
InterPro Domains

IPR011989 Armadillo-like helical

IPR016024 Armadillo-type fold

IPR051177 Catalytically Inactive Kinase-Related Protein

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily
GlyGen

Q8CFE4 4 sites, 1 O-linked glycan (4 sites)

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All nucleic 66

cDNA 65

Primer pair 1

Microarray probesets 3

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MGI:2143723, MGI:2143847, MGI:2446127

Summaries

All 39

Gene Ontology 6

Phenotypes 14
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:225808 Gingras S, et al., SCYL2 Protects CA3 Pyramidal Neurons from Excitotoxicity during Functional Maturation of the Mouse Hippocampus. J Neurosci. 2015 Jul 22;35(29):10510-22

TSS for Scyl2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr98890	Chr10:89522112-89522168 (-)	7 bp
Tssr98889	Chr10:89522081-89522106 (-)	53 bp
Tssr98888	Chr10:89522059-89522076 (-)	79 bp
Tssr98887	Chr10:89510052-89510057 (-)	12,092 bp
Tssr98886	Chr10:89482885-89482897 (-)	39,256 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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