Zwint MGI Mouse Gene Detail - MGI:1289227

Symbol

Zwint
Name

ZW10 interactor
Synonyms

2010007E07Rik, 2600001N01Rik, D10Ertd749e

Feature Type

protein coding gene
IDs

MGI:1289227
NCBI Gene: 52696
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr10:72490678-72510796 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 37.15 cM
Mapping Data

3 experiments

SNPs within 2kb

628 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1289227	protein coding gene	Chr10:72490677-72510796 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017346	protein coding gene	Chr10:72710372-72730394 (+)
A/J	MGP_AJ_G0017323	protein coding gene	Chr10:70258084-70278189 (+)
AKR/J	MGP_AKRJ_G0017284	protein coding gene	Chr10:72119327-72139419 (+)
BALB/cJ	MGP_BALBcJ_G0017283	protein coding gene	Chr10:70385364-70405401 (+)
C3H/HeJ	MGP_C3HHeJ_G0017107	protein coding gene	Chr10:72127507-72147655 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017741	protein coding gene	Chr10:75254313-75280634 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015431	protein coding gene	Chr10:66609885-66629926 (+)
CAST/EiJ	MGP_CASTEiJ_G0016677	protein coding gene	Chr10:72284523-72305789 (+)
CBA/J	MGP_CBAJ_G0017079	protein coding gene	Chr10:78183018-78206643 (+)
DBA/2J	MGP_DBA2J_G0017184	protein coding gene	Chr10:69545362-69565349 (+)
FVB/NJ	MGP_FVBNJ_G0017177	protein coding gene	Chr10:68690450-68710547 (+)
LP/J	MGP_LPJ_G0017257	protein coding gene	Chr10:73170297-73190362 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017205	protein coding gene	Chr10:80256592-80277700 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017780	protein coding gene	Chr10:72107084-72127215 (+)
PWK/PhJ	MGP_PWKPhJ_G0016461	protein coding gene	Chr10:69363852-69384808 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016244	protein coding gene	Chr10:71384534-71404713 (+)
WSB/EiJ	MGP_WSBEiJ_G0016741	protein coding gene	Chr10:72101434-72121571 (+)

Human Ortholog

ZWINT, ZW10 interacting kinetochore protein

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ZWINT, ZW10 interacting kinetochore protein
Synonyms

HZwint-1, KNTC2AP, SIP30, ZWINT1
Links

HGNC:13195

NCBI Gene ID: 11130

neXtProt AC: NX_O95229

UniProt: O95229
Chr Location

10q21.1; chr10:56357227-56361273 (-) GRCh38

MGI Vertebrate Homology

Zwint stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: ZWINT
Gene Tree

Zwint

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Phenotype Summary

6 phenotypes from 1 allele in 1 genetic background
1 images
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (other)

1
Endonuclease-mediated

5
Gene trapped

1
Radiation induced

1
Targeted

2
Genomic Mutations

2 involving Zwint
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

21 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit complete embryonic lethality prior to organogenesis. Although blastocysts hatch from the zona pellucida with apparent trophectoderm and primitive endoderm cells, inner cell mass and epiblast cells form smaller outgrowth colonies.

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All GO Annotations

30
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

848
Tissues

59
cDNA Data

297
Literature Summary

8

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas

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All Sequences

57
RefSeq

6
UniProt

2
CCDS

CCDS23920.1

Ensembl

ENSMUSG00000019923 (Evidence)
NCBI Gene

52696

			Length	Strain/Species	Flank
genomic	52696	NCBI Gene Model \| MGI Sequence Detail	20119	C57BL/6J	± kb
transcript	NM_025635	RefSeq \| MGI Sequence Detail	2729	ZRU/MplStud
polypeptide	Q9CQU5	UniProt \| EBI \| MGI Sequence Detail	252	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000018237 ZW10 interactor

(term hierarchy)
InterPro Domains

IPR029092 ZW10 interactor
GlyGen

Q9CQU5 1 site, 1 O-linked glycan (1 site)

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All nucleic 300

cDNA 297

Primer pair 3

Microarray probesets 8

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MGI:1913814, MGI:1917100

Summaries

All 54

Developmental Gene Expression 8

Gene Ontology 10

Phenotypes 16
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Zwint:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr94037	Chr10:72490687-72490698 (+)	15 bp
Tssr94038	Chr10:72490705-72490752 (+)	51 bp
Tssr94041	Chr10:72507185-72507201 (+)	16,515 bp
Tssr94042	Chr10:72507206-72507219 (+)	16,535 bp
Tssr94043	Chr10:72509809-72509847 (+)	19,150 bp
Tssr94044	Chr10:72510053-72510187 (+)	19,442 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24