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Rhpn2 Gene Detail
Summary
  • Symbol
    Rhpn2
  • Name
    rhophilin, Rho GTPase binding protein 2
  • Synonyms
    1300002E07Rik, D7Ertd784e
  • Feature Type
    protein coding gene
  • IDs
    MGI:1289234
    NCBI Gene: 52428
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:35033605-35091712 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 21.36 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1939 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1289234
 protein coding gene Chr7:35033595-35091714 (+)
129S1/SvImJ MGP_129S1SvImJ_G0032086
 protein coding gene Chr7:34716207-34782980 (+)
A/J MGP_AJ_G0032066
 protein coding gene Chr7:33787686-33844917 (+)
AKR/J MGP_AKRJ_G0031999
 protein coding gene Chr7:34610058-34672896 (+)
BALB/cJ MGP_BALBcJ_G0032073
 protein coding gene Chr7:34083757-34144647 (+)
C3H/HeJ MGP_C3HHeJ_G0031790
 protein coding gene Chr7:35498892-35561612 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032550
 protein coding gene Chr7:36431470-36499601 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029583
 protein coding gene Chr7:34509762-34568999 (+)
CAST/EiJ MGP_CASTEiJ_G0031125
 protein coding gene Chr7:26655926-26722691 (+)
CBA/J MGP_CBAJ_G0031758
 protein coding gene Chr7:37571779-37636873 (+)
DBA/2J MGP_DBA2J_G0031910
 protein coding gene Chr7:33640487-33697719 (+)
FVB/NJ MGP_FVBNJ_G0031865
 protein coding gene Chr7:33565536-33627489 (+)
LP/J MGP_LPJ_G0031987
 protein coding gene Chr7:35047435-35111672 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031903
 protein coding gene Chr7:36578625-36648144 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032565
 protein coding gene Chr7:34152923-34220445 (+)
PWK/PhJ MGP_PWKPhJ_G0030847
 protein coding gene Chr7:26970145-27030895 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030682
 protein coding gene Chr7:23724580-23785880 (+)
WSB/EiJ MGP_WSBEiJ_G0031235
 protein coding gene Chr7:34702323-34765371 (+)



Homology
more
  • Human Ortholog
    RHPN2, rhophilin Rho GTPase binding protein 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RHPN2, rhophilin Rho GTPase binding protein 2
  • Synonyms
    P76RBE, RHOBP
  • Links
    NCBI Gene ID: 85415
    neXtProt AC: NX_Q8IUC4
    UniProt: Q8IUC4

  • Chr Location
    19q13.11; chr19:32978592-33064888 (-)  GRCh38
  • Human Ortholog
    RHPN2P1, rhophilin Rho GTPase binding protein 2 pseudogene 1
  • Links
    NCBI Gene ID: 646090
    UniProt: A8MT19

  • Chr Location
    15q11.1; chr15:20228419-20276864 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    7 phenotypes from multigenic genotypes
    9 phenotype references
Homozygous null mice are fertile and have normal body weight and size, normal thyroid morphology and function, and normal brain, lung, ovary, testis, and kidney morphology.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    6
  • GO References
    5
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    717
  • Tissues
    10
  • cDNA Data
    12
  • Literature Summary
    2
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 52428 NCBI Gene Model | MGI Sequence Detail 58108 C57BL/6J ±  kb
transcript NM_027897 RefSeq | MGI Sequence Detail 3439 ZRU/MplStud  
polypeptide Q8BWR8 UniProt | EBI | MGI Sequence Detail 686 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 14
    cDNA 12
    Primer pair 2

    Microarray probesets 5
Other
Accession IDs
less
MGI:1918997, MGI:2141835, MGI:2142360
References
more
  • Summaries
    All 35
    Developmental Gene Expression 2
    Gene Ontology 5
    Phenotypes 9
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:281175 Yorgan TA, et al., Osteoblast-specific expression of Panx3 is dispensable for postnatal bone remodeling. Bone. 2019 Oct;127:155-163
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory