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Txndc17 Gene Detail
Summary
  • Symbol
    Txndc17
  • Name
    thioredoxin domain containing 17
  • Synonyms
    4831443O22Rik, D11Ertd672e, TRP14, Txnl5
  • Feature Type
    protein coding gene
  • IDs
    MGI:1289248
    NCBI Gene: 52700
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:72098373-72100841 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 43.92 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    96 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1289248
 protein coding gene Chr11:72098373-72101313 (+)
129S1/SvImJ MGP_129S1SvImJ_G0018632
 protein coding gene Chr11:72825447-72827913 (+)
A/J MGP_AJ_G0018600
 protein coding gene Chr11:70099988-70102454 (+)
AKR/J MGP_AKRJ_G0018569
 protein coding gene Chr11:72232993-72235461 (+)
BALB/cJ MGP_BALBcJ_G0018572
 protein coding gene Chr11:70394773-70397241 (+)
C3H/HeJ MGP_C3HHeJ_G0018385
 protein coding gene Chr11:72194330-72196798 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019023
 protein coding gene Chr11:75023507-75025975 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016666
 protein coding gene Chr11:66941102-66943559 (+)
CAST/EiJ MGP_CASTEiJ_G0017940
 protein coding gene Chr11:72567329-72569795 (+)
CBA/J MGP_CBAJ_G0018357
 protein coding gene Chr11:78347361-78349829 (+)
DBA/2J MGP_DBA2J_G0018466
 protein coding gene Chr11:69750070-69752558 (+)
FVB/NJ MGP_FVBNJ_G0018457
 protein coding gene Chr11:69274419-69276887 (+)
LP/J MGP_LPJ_G0018537
 protein coding gene Chr11:73333287-73335753 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018480
 protein coding gene Chr11:78924135-78926603 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019065
 protein coding gene Chr11:72437562-72440028 (+)
PWK/PhJ MGP_PWKPhJ_G0017713
 protein coding gene Chr11:70362142-70364631 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017503
 protein coding gene Chr11:72143874-72146350 (+)
WSB/EiJ MGP_WSBEiJ_G0017994
 protein coding gene Chr11:72176166-72178632 (+)



Homology
more
  • Human Ortholog
    TXNDC17, thioredoxin domain containing 17
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TXNDC17, thioredoxin domain containing 17
  • Synonyms
    TRP14, TXNL5
  • Links
    NCBI Gene ID: 84817
    neXtProt AC: NX_Q9BRA2
    UniProt: Q9BRA2

  • Chr Location
    17p13.1; chr17:6640985-6644541 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    83
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000020803 Ensembl Gene Model | MGI Sequence Detail 2469 C57BL/6J ±  kb
transcript ENSMUST00000021158 Ensembl | MGI Sequence Detail 981 Not Applicable  
polypeptide ENSMUSP00000021158 Ensembl | MGI Sequence Detail 123 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000016859 thioredoxin domain-containing protein 17
    (term hierarchy)
  • PDB
    1V9W
  • InterPro Domains
    IPR045108 Thioredoxin domain-containing protein 17-like
    IPR010357 Thioredoxin domain-containing protein 17-like domain
    IPR036249 Thioredoxin-like superfamily
  • GlyGen
    Q9CQM5 1 site, 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 84
    cDNA 83
    Primer pair 1

    Microarray probesets 5
Other
Accession IDs
less
MGI:1915352
References
more
  • Summaries
    All 40
    Gene Ontology 4
    Phenotypes 12
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:354146 Marti-Andres P, et al., TRP14 is the rate-limiting enzyme for intracellular cystine reduction and regulates proteome cysteinylation. EMBO J. 2024 Jul;43(13):2789-2812
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory