Krr1 MGI Mouse Gene Detail - MGI:1289274 - KRR1, small subunit (SSU) processome component, homolog (yeast)

Symbol

Krr1
Name

KRR1, small subunit (SSU) processome component, homolog (yeast)
Synonyms

2610511F02Rik, D10Ertd773e, Hrb2

Feature Type

protein coding gene
IDs

MGI:1289274
NCBI Gene: 52705
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr10:111808600-111824335 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 59.97 cM
Mapping Data

3 experiments

SNPs within 2kb

654 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1289274	protein coding gene	Chr10:111808569-111824337 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017723	protein coding gene	Chr10:114440652-114456350 (+)
A/J	MGP_AJ_G0017700	protein coding gene	Chr10:110067933-110083445 (+)
AKR/J	MGP_AKRJ_G0017662	protein coding gene	Chr10:113289163-113304808 (+)
BALB/cJ	MGP_BALBcJ_G0017664	protein coding gene	Chr10:110472663-110488368 (+)
C3H/HeJ	MGP_C3HHeJ_G0017489	protein coding gene	Chr10:113436498-113453031 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018121	protein coding gene	Chr10:118371881-118390216 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015800	protein coding gene	Chr10:104925436-104941176 (+)
CAST/EiJ	MGP_CASTEiJ_G0017050	protein coding gene	Chr10:113623626-113656161 (+)
CBA/J	MGP_CBAJ_G0017458	protein coding gene	Chr10:123023291-123041272 (+)
DBA/2J	MGP_DBA2J_G0017563	protein coding gene	Chr10:109209746-109225468 (+)
FVB/NJ	MGP_FVBNJ_G0017557	protein coding gene	Chr10:108193570-108209787 (+)
LP/J	MGP_LPJ_G0017637	protein coding gene	Chr10:115075023-115090822 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017586	protein coding gene	Chr10:125632545-125649596 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018159	protein coding gene	Chr10:113307199-113322736 (+)
PWK/PhJ	MGP_PWKPhJ_G0016832	protein coding gene	Chr10:109290385-109306426 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016622	protein coding gene	Chr10:112080789-112098606 (+)
WSB/EiJ	MGP_WSBEiJ_G0017110	protein coding gene	Chr10:113448435-113464141 (+)

Human Ortholog

KRR1, KRR1 small subunit processome component homolog

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

KRR1, KRR1 small subunit processome component homolog
Synonyms

HRB2, RIP-1
Links

HGNC:5176

NCBI Gene ID: 11103

neXtProt AC: NX_Q13601

UniProt: Q13601
Chr Location

12q21.2; chr12:75490863-75511636 (-) GRCh38

MGI Vertebrate Homology

Krr1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: KRR1
Protein SuperFamily

KRR1
Gene Tree

Krr1

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Phenotype Summary

12 phenotype references

All Mutations and Alleles

13
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

9
Genomic Mutations

1 involving Krr1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

25 strains or lines available

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All GO Annotations

16
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

785
Tissues

26
cDNA Data

125
Literature Summary

2

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase krr1

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All Sequences

53
RefSeq

2
UniProt

3
CCDS

CCDS24168.1

Ensembl

ENSMUSG00000063334 (Evidence)
NCBI Gene

52705

			Length	Strain/Species	Flank
genomic	52705	NCBI Gene Model \| MGI Sequence Detail	15736	C57BL/6J	± kb
transcript	NM_178610	RefSeq \| MGI Sequence Detail	4990	ZRU/MplStud
polypeptide	Q8BGA5	UniProt \| EBI \| MGI Sequence Detail	380	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000009449 KRR1 small subunit processome component

(term hierarchy)
InterPro Domains

IPR004087 K Homology domain

IPR036612 K Homology domain, type 1 superfamily

IPR041174 KRR1 small subunit processome component, first KH domain

IPR048550 KRR1 small subunit processome component, first KH domain, eukaryotes

IPR048548 KRR1 small subunit processome component, second KH domain

IPR048549 KRR1 small subunit processome component, second KH domain, eukaryotes

IPR024166 Ribosomal RNA assembly KRR1

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All nucleic 127

cDNA 125

Primer pair 2

Microarray probesets 9

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MGI:1914319, MGI:2143545, MGI:2143594

Summaries

All 44

Developmental Gene Expression 2

Gene Ontology 6

Phenotypes 12
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582

TSS for Krr1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr95777	Chr10:111808655-111808710 (+)	83 bp
Tssr95778	Chr10:111820734-111820752 (+)	12,143 bp
Tssr95779	Chr10:111821361-111821368 (+)	12,765 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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