Slc52a2 MGI Mouse Gene Detail - MGI:1289288 - solute carrier protein 52, member 2

Symbol

Slc52a2
Name

solute carrier protein 52, member 2
Synonyms

2010003P03Rik, D15Ertd747e, GPCR42, Gpr172b, PAR2, Rfvt2

Feature Type

protein coding gene
IDs

MGI:1289288
NCBI Gene: 52710
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr15:76423032-76428808 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 36.04 cM
Mapping Data

3 experiments

SNPs within 2kb

189 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1289288	protein coding gene	Chr15:76422994-76432078 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0021998	protein coding gene	Chr15:76618101-76621288 (+)
A/J	MGP_AJ_G0021956	protein coding gene	Chr15:73828299-73831486 (+)
AKR/J	MGP_AKRJ_G0021939	protein coding gene	Chr15:75829111-75832298 (+)
BALB/cJ	MGP_BALBcJ_G0021965	protein coding gene	Chr15:73857548-73860735 (+)
C3H/HeJ	MGP_C3HHeJ_G0021737	protein coding gene	Chr15:75876973-75880160 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0022405	protein coding gene	Chr15:79485624-79488811 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019934	protein coding gene	Chr15:70491877-70494145 (+)
CAST/EiJ	MGP_CASTEiJ_G0021256	protein coding gene	Chr15:76679135-76683440 (+)
CBA/J	MGP_CBAJ_G0021704	protein coding gene	Chr15:81999293-82002480 (+)
DBA/2J	MGP_DBA2J_G0021829	protein coding gene	Chr15:73365761-73368948 (+)
FVB/NJ	MGP_FVBNJ_G0021809	protein coding gene	Chr15:72422574-72425761 (+)
LP/J	MGP_LPJ_G0021900	protein coding gene	Chr15:76717716-76720903 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021834	protein coding gene	Chr15:87328531-87331719 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022425	protein coding gene	Chr15:76083461-76091273 (+)
PWK/PhJ	MGP_PWKPhJ_G0020997	protein coding gene	Chr15:73531426-73534612 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0020837	protein coding gene	Chr15:75801984-75805131 (+)
WSB/EiJ	MGP_WSBEiJ_G0021308	protein coding gene	Chr15:76190430-76193613 (+)

Human Ortholog

SLC52A1, solute carrier family 52 member 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SLC52A1, solute carrier family 52 member 1
Synonyms

GPCR42, GPR172B, hRFT1, huPAR-2, PAR2, RBFVD, RFT1, RFVT1
Links

HGNC:30225

NCBI Gene ID: 55065

neXtProt AC: NX_Q9NWF4

UniProt: Q9NWF4
Chr Location

17p13.2; chr17:5032600-5052009 (-) GRCh38

Human Ortholog

SLC52A2, solute carrier family 52 member 2
Synonyms

BVVLS2, D15Ertd747e, GPCR41, GPR172A, hRFT3, HuPAR-1, PAR1, RFT3, RFVT2
Links

HGNC:30224

NCBI Gene ID: 79581

neXtProt AC: NX_Q9HAB3

UniProt: Q9HAB3
Chr Location

8q24.3; chr8:144333957-144361286 (+) GRCh38

MGI Vertebrate Homology

Slc52a2 stringent orthology
2 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SLC52A1, SLC52A2
Gene Tree

Slc52a2

Diseases

2 with human SLC52A1,SLC52A2 associations

				Human Disease	Mouse Models
				Brown-Vialetto-Van Laere syndrome 2 IDs Brown-Vialetto-Van Laere syndrome 2 DOID:0080786 OMIM:614707
				riboflavin deficiency IDs riboflavin deficiency DOID:8454 ICD10CM:E53.0 ICD9CM:266.0 MESH:D012257 UMLS_CUI:C0035528

Click on a disease name to see all genes associated with that disease.

References

1 with disease annotations

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Phenotype Summary

6 phenotypes from 2 alleles in 2 genetic backgrounds
37 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

15
Chemically induced (other)

3
Endonuclease-mediated

2
Gene trapped

5
Radiation induced

2
Targeted

3
Genomic Mutations

5 involving Slc52a2
Incidental Mutations

Mutagenetix , CvDC
Find Mice (IMSR)

21 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele die prior to E10.5.

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All GO Annotations

23
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

708
Tissues

2
cDNA Data

67
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase slc52a1

ZFIN slc52a2

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All Sequences

52
RefSeq

5
UniProt

1
CCDS

CCDS27575.1

Ensembl

ENSMUSG00000022560 (Evidence)
NCBI Gene

52710

			Length	Strain/Species	Flank
genomic	ENSMUSG00000022560	Ensembl Gene Model \| MGI Sequence Detail	5777	C57BL/6J	± kb
transcript	ENSMUST00000023220	Ensembl \| MGI Sequence Detail	5289	Not Applicable
polypeptide	ENSMUSP00000023220	Ensembl \| MGI Sequence Detail	450	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000008188 solute carrier family 52, riboflavin transporter, member 1

(term hierarchy)
InterPro Domains

IPR009357 Solute carrier family 52, riboflavin transporter
GlyGen

Q9D8F3 1 site, 1 N-linked glycan (1 site)

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All nucleic 69

cDNA 67

Primer pair 2

Microarray probesets 7

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MGI:1923771

Summaries

All 69

Developmental Gene Expression 1

Diseases 1

Gene Ontology 6

Phenotypes 37
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Slc52a2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr131798	Chr15:76423012-76423076 (+)	12 bp
Tssr131799	Chr15:76423077-76423103 (+)	58 bp
Tssr131800	Chr15:76423134-76423161 (+)	116 bp
Tssr131801	Chr15:76423167-76423202 (+)	153 bp
Tssr131802	Chr15:76423238-76423257 (+)	216 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24