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Knstrn Gene Detail
Summary
  • Symbol
    Knstrn
  • Name
    kinetochore-localized astrin/SPAG5 binding
  • Synonyms
    1700025D04Rik, D2Ertd750e
  • Feature Type
    protein coding gene
  • IDs
    MGI:1289298
    NCBI Gene: 51944
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:118644470-118667691 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 59.46 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    665 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1289298
 protein coding gene Chr2:118644470-118684438 (+)
129S1/SvImJ MGP_129S1SvImJ_G0026324
 protein coding gene Chr2:121518891-121566066 (+)
A/J MGP_AJ_G0026285
 protein coding gene Chr2:116587819-116627061 (+)
AKR/J MGP_AKRJ_G0026264
 protein coding gene Chr2:119853732-119892895 (+)
BALB/cJ MGP_BALBcJ_G0026298
 protein coding gene Chr2:116850039-116891168 (+)
C3H/HeJ MGP_C3HHeJ_G0026044
 protein coding gene Chr2:120321246-120361548 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026745
 protein coding gene Chr2:125522572-125568484 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024125
 protein coding gene Chr2:111631200-111670677 (+)
CAST/EiJ MGP_CASTEiJ_G0025506
 protein coding gene Chr2:120625792-120665959 (+)
CBA/J MGP_CBAJ_G0026020
 protein coding gene Chr2:129953366-129996587 (+)
DBA/2J MGP_DBA2J_G0026159
 protein coding gene Chr2:116014179-116054638 (+)
FVB/NJ MGP_FVBNJ_G0026121
 protein coding gene Chr2:114835631-114877409 (+)
LP/J MGP_LPJ_G0026260
 protein coding gene Chr2:121848043-121888959 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026140
 protein coding gene Chr2:134320363-134362250 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026800
 protein coding gene Chr2:119978721-120018917 (+)
PWK/PhJ MGP_PWKPhJ_G0025242
 protein coding gene Chr2:115563639-115602876 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025041
 protein coding gene Chr2:119149256-119192445 (+)
WSB/EiJ MGP_WSBEiJ_G0025575
 protein coding gene Chr2:120801144-120843190 (+)



Homology
more
  • Human Ortholog
    KNSTRN, kinetochore localized astrin (SPAG5) binding protein
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KNSTRN, kinetochore localized astrin (SPAG5) binding protein
  • Synonyms
    C15orf23, HSD11, ROCHIS, SKAP, TRAF4AF1
  • Links
    NCBI Gene ID: 90417
    neXtProt AC: NX_Q9Y448
    UniProt: Q9Y448

  • Chr Location
    15q15.1; chr15:40382721-40394288 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human KNSTRN associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    20 phenotypes from 2 alleles in 2 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele display reduced fertility, decreased testis size, oligozoospermia, and defects in early spermatogenesis associated with abnormal spermatogonia proliferation and increased testis apoptosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    42
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    707
  • Tissues
    1
  • cDNA Data
    112
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 51944 NCBI Gene Model | MGI Sequence Detail 23222 C57BL/6J ±  kb
    transcript NM_026412 RefSeq | MGI Sequence Detail 3118 C57BL/6  
    polypeptide Q9D9Z1 UniProt | EBI | MGI Sequence Detail 312 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 113
      cDNA 112
      Primer pair 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1915103
    References
    more
    • Summaries
      All 44
      Developmental Gene Expression 2
      Gene Ontology 7
      Phenotypes 14
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory