Tax1bp1 MGI Mouse Gene Detail - MGI:1289308 - Tax1 (human T cell leukemia virus type I) binding protein 1

Symbol

Tax1bp1
Name

Tax1 (human T cell leukemia virus type I) binding protein 1
Synonyms

1200003J11Rik, 1700069J21Rik, D6Ertd404e, D6Ertd772e, T6BP, TXBP151

Feature Type

protein coding gene
IDs

MGI:1289308
NCBI Gene: 52440
Alliance

gene page
Transcription Start Sites

14 TSS

Sequence Map

Chr6:52690714-52743765 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 25.70 cM
Mapping Data

5 experiments

SNPs within 2kb

927 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1289308	protein coding gene	Chr6:52690677-52743765 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0030753	protein coding gene	Chr6:52000514-52057094 (+)
A/J	MGP_AJ_G0030722	protein coding gene	Chr6:49571621-49624837 (+)
AKR/J	MGP_AKRJ_G0030649	protein coding gene	Chr6:51294355-51348096 (+)
BALB/cJ	MGP_BALBcJ_G0030734	protein coding gene	Chr6:49919002-49973335 (+)
C3H/HeJ	MGP_C3HHeJ_G0030447	protein coding gene	Chr6:51294740-51350032 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0031189	protein coding gene	Chr6:53144986-53204714 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028395	protein coding gene	Chr6:47199854-47259446 (+)
CAST/EiJ	MGP_CASTEiJ_G0029850	protein coding gene	Chr6:51117220-51176202 (+)
CBA/J	MGP_CBAJ_G0030421	protein coding gene	Chr6:55371714-55433506 (+)
DBA/2J	MGP_DBA2J_G0030571	protein coding gene	Chr6:49482089-49534922 (+)
FVB/NJ	MGP_FVBNJ_G0030523	protein coding gene	Chr6:49083104-49136284 (+)
LP/J	MGP_LPJ_G0030656	protein coding gene	Chr6:51958721-52016499 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0030557	protein coding gene	Chr6:57978955-58038066 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0031219	protein coding gene	Chr6:51234218-51286356 (+)
PWK/PhJ	MGP_PWKPhJ_G0029563	protein coding gene	Chr6:49108405-49163987 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0029397	protein coding gene	Chr6:50554840-50612558 (+)
WSB/EiJ	MGP_WSBEiJ_G0029927	protein coding gene	Chr6:51227750-51283747 (+)

Human Ortholog

TAX1BP1, Tax1 binding protein 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TAX1BP1, Tax1 binding protein 1
Synonyms

CALCOCO3, T6BP, TXBP151
Links

HGNC:11575

NCBI Gene ID: 8887

neXtProt AC: NX_Q86VP1

UniProt: Q86VP1
Chr Location

7p15.2; chr7:27739331-27844564 (+) GRCh38

MGI Vertebrate Homology

Tax1bp1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: TAX1BP1
Gene Tree

Tax1bp1

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Phenotype Summary

17 phenotypes from 2 alleles in 2 genetic backgrounds
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Endonuclease-mediated

1
Gene trapped

5
Targeted

4
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

38 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Knockout mice are born alive but fail to thrive and develop inflammatory cardiac valvulitis and dermatitis, die prematurely, and are hypersensitive to low doses of TNF and IL-1beta. In contrast, embryos homozygous for a gene trap mutation die at E13.5 from hemorrhaging and/or cardiac defects.

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All GO Annotations

24
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

718
Tissues

7
cDNA Data

351
Literature Summary

2

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tax1bp1

ZFIN tax1bp1a, tax1bp1b

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All Sequences

63
RefSeq

8
UniProt

4
CCDS

CCDS39490.1

Ensembl

ENSMUSG00000004535 (Evidence)
NCBI Gene

52440

			Length	Strain/Species	Flank
genomic	ENSMUSG00000004535	Ensembl Gene Model \| MGI Sequence Detail	53052	C57BL/6J	± kb
transcript	ENSMUST00000080723	Ensembl \| MGI Sequence Detail	3285	Not Applicable
polypeptide	ENSMUSP00000079548	Ensembl \| MGI Sequence Detail	814	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000016090 Tax1-binding protein 1

(term hierarchy)
InterPro Domains

IPR012852 Calcium binding and coiled-coil domain-like

IPR041641 CALCOCO1/2, zinc finger UBZ1-type

IPR041611 SKICH domain

IPR051002 Ubiquitin-binding and autophagy-associated domain-containing protein

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All nucleic 356

cDNA 353

Primer pair 3

Microarray probesets 8

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MGI:1196306, MGI:1889378, MGI:1914122, MGI:1920756

Summaries

All 51

Developmental Gene Expression 2

Gene Ontology 8

Phenotypes 13
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:300172 Sarraf SA, et al., Loss of TAX1BP1-Directed Autophagy Results in Protein Aggregate Accumulation in the Brain. Mol Cell. 2020 Dec 3;80(5):779-795.e10

TSS for Tax1bp1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr56527	Chr6:52690716-52690785 (+)	37 bp
Tssr56528	Chr6:52690988-52691034 (+)	297 bp
Tssr56529	Chr6:52691035-52691063 (+)	335 bp
Tssr56530	Chr6:52691397-52691425 (+)	697 bp
Tssr56531	Chr6:52691430-52691452 (+)	727 bp
Tssr56532	Chr6:52697304-52697309 (+)	6,593 bp
Tssr56533	Chr6:52698351-52698364 (+)	7,644 bp
Tssr56534	Chr6:52698379-52698413 (+)	7,682 bp
Tssr56535	Chr6:52704177-52704215 (+)	13,482 bp
Tssr56536	Chr6:52706316-52706355 (+)	15,622 bp
Tssr56537	Chr6:52706397-52706430 (+)	15,700 bp
Tssr56538	Chr6:52710169-52710184 (+)	19,463 bp
Tssr56539	Chr6:52714062-52714096 (+)	23,365 bp
Tssr56540	Chr6:52722680-52722683 (+)	31,968 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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