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Slc7a5 Gene Detail
Summary
  • Symbol
    Slc7a5
  • Name
    solute carrier family 7 (cationic amino acid transporter, y+ system), member 5
  • Synonyms
    D0H16S474E, Gm42049, LAT1, TA1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1298205
    NCBI Gene: 20539
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:122607885-122634425 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, Syntenic
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    879 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1298205
 protein coding gene Chr8:122607885-122634433 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034217
 protein coding gene Chr8:125399401-125427742 (-)
A/J MGP_AJ_G0034197
 protein coding gene Chr8:120196427-120224075 (-)
AKR/J MGP_AKRJ_G0034124
 protein coding gene Chr8:123723664-123751249 (-)
BALB/cJ MGP_BALBcJ_G0034191
 protein coding gene Chr8:120402404-120430019 (-)
C3H/HeJ MGP_C3HHeJ_G0033902
 protein coding gene Chr8:124414876-124443120 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034711
 protein coding gene Chr8:129581885-129610708 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031653
 protein coding gene Chr8:113030585-113058857 (-)
CAST/EiJ MGP_CASTEiJ_G0033229
 protein coding gene Chr8:124469101-124495616 (-)
CBA/J MGP_CBAJ_G0033875
 protein coding gene Chr8:134361461-134391000 (-)
DBA/2J MGP_DBA2J_G0034031
 protein coding gene Chr8:119395263-119421884 (-)
FVB/NJ MGP_FVBNJ_G0033974
 protein coding gene Chr8:118504991-118531667 (-)
LP/J MGP_LPJ_G0034120
 protein coding gene Chr8:125525671-125552347 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034021
 protein coding gene Chr8:136564592-136591267 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034729
 protein coding gene Chr8:123893253-123919843 (-)
PWK/PhJ MGP_PWKPhJ_G0032931
 protein coding gene Chr8:119199865-119226604 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032771
 protein coding gene Chr8:122601643-122629563 (-)
WSB/EiJ MGP_WSBEiJ_G0033345
 protein coding gene Chr8:124645137-124671464 (-)



Homology
more
  • Human Ortholog
    SLC7A5, solute carrier family 7 member 5
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLC7A5, solute carrier family 7 member 5
  • Synonyms
    4F2LC, CD98, D16S469E, E16, LAT1, MPE16
  • Links
    NCBI Gene ID: 8140
    neXtProt AC: NX_Q01650
    UniProt: Q01650

  • Chr Location
    16q24.2; chr16:87830023-87869507 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Slc7a5 mouse models; 4 with human SLC7A5 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    31 phenotypes from 4 alleles in 5 genetic backgrounds
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted mutation die prenatally.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    100
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    920
  • Tissues
    77
  • cDNA Data
    80
  • Literature Summary
    22
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20539 NCBI Gene Model | MGI Sequence Detail 26541 C57BL/6J ±  kb
    transcript NM_011404 RefSeq | MGI Sequence Detail 3513 ZRU/MplStud  
    polypeptide Q9Z127 UniProt | EBI | MGI Sequence Detail 512 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000015201 large neutral amino acids transporter small subunit 1
      (term hierarchy)
    • InterPro Domains
      IPR002293 Amino acid/polyamine transporter I
      IPR050598 Cellular Amino Acid Transporter
      IPR004760 L-type amino acid transporter
    • GlyGen
      Q9Z127 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 89
      cDNA 80
      Primer pair 8
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:5624934
    References
    more
    • Summaries
      All 80
      Developmental Gene Expression 22
      Diseases 1
      Gene Ontology 8
      Phenotypes 23
    • Earliest
      J:48072 Kimura N, et al., Entactin-2: a new member of basement membrane protein with high homology to entactin/ nidogen. Exp Cell Res. 1998 May 25;241(1):36-45
    • Latest
      J:352336 Bao L, et al., Amino acid transporter SLC7A5 regulates cell proliferation and secretary cell differentiation and distribution in the mouse intestine. Int J Biol Sci. 2024;20(6):2187-2201
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory