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Pip4k2a Gene Detail
Summary
  • Symbol
    Pip4k2a
  • Name
    phosphatidylinositol-5-phosphate 4-kinase, type II, alpha
  • Synonyms
    Pip5k2a
  • Feature Type
    protein coding gene
  • IDs
    MGI:1298206
    NCBI Gene: 18718
  • Alliance
    gene page
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:18847066-19002937 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 12.93 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4885 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1298206
 protein coding gene Chr2:18847066-19003101 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025378
 protein coding gene Chr2:16565750-16723286 (-)
A/J MGP_AJ_G0025356
 protein coding gene Chr2:15898234-16051561 (-)
AKR/J MGP_AKRJ_G0025324
 protein coding gene Chr2:16431403-16596221 (-)
BALB/cJ MGP_BALBcJ_G0025351
 protein coding gene Chr2:15925121-16079064 (-)
C3H/HeJ MGP_C3HHeJ_G0025111
 protein coding gene Chr2:16348713-16507610 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025794
 protein coding gene Chr2:16994894-17156731 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023209
 protein coding gene Chr2:15283012-15436059 (-)
CAST/EiJ MGP_CASTEiJ_G0024575
 protein coding gene Chr2:16313016-16471558 (-)
CBA/J MGP_CBAJ_G0025090
 protein coding gene Chr2:17757639-17916670 (-)
DBA/2J MGP_DBA2J_G0025222
 protein coding gene Chr2:15823380-15979669 (-)
FVB/NJ MGP_FVBNJ_G0025185
 protein coding gene Chr2:15619091-15770829 (-)
LP/J MGP_LPJ_G0025309
 protein coding gene Chr2:16408016-16569494 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025216
 protein coding gene Chr2:17708028-17873529 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025852
 protein coding gene Chr2:16380822-16538302 (-)
PWK/PhJ MGP_PWKPhJ_G0024324
 protein coding gene Chr2:15702840-15864622 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024124
 protein coding gene Chr2:16495558-16656271 (-)
WSB/EiJ MGP_WSBEiJ_G0024645
 protein coding gene Chr2:16443737-16598659 (-)



Homology
more
  • Human Ortholog
    PIP4K2A, phosphatidylinositol-5-phosphate 4-kinase type 2 alpha
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PIP4K2A, phosphatidylinositol-5-phosphate 4-kinase type 2 alpha
  • Synonyms
    PI5P4KA, PIP5K2A, PIP5KIIA, PIP5KII-alpha, PIPK
  • Links
    NCBI Gene ID: 5305
    neXtProt AC: NX_P48426
    UniProt: P48426

  • Chr Location
    10p12.2; chr10:22534854-22714578 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    5 phenotypes from multigenic genotypes
    13 phenotype references
Mice homozygous for a null allele are viable and appear phenotypically normal.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    35
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1171
  • Tissues
    184
  • cDNA Data
    9
  • Literature Summary
    9
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000026737 Ensembl Gene Model | MGI Sequence Detail 155872 C57BL/6J ±  kb
transcript ENSMUST00000006912 Ensembl | MGI Sequence Detail 3477 Not Applicable  
polypeptide ENSMUSP00000006912 Ensembl | MGI Sequence Detail 405 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000012741 phosphatidylinositol 5-phosphate 4-kinase type-2 alpha
    (term hierarchy)
  • EC
    2.7.1.149
  • InterPro Domains
    IPR023610 Phosphatidylinositol-4/5-phosphate 5/4-kinase
    IPR002498 Phosphatidylinositol-4-phosphate 4/5-kinase, core
    IPR027483 Phosphatidylinositol-4-phosphate 4/5-kinase, C-terminal domain superfamily
    IPR027484 Phosphatidylinositol-4-phosphate 5-kinase, N-terminal
  • GlyGen
    O70172 1 site, 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 12
    cDNA 9
    Primer pair 2
    Other 1

    Microarray probesets 8
Other
Accession IDs
less
MGI:2139412
References
more
  • Summaries
    All 49
    Developmental Gene Expression 9
    Gene Ontology 11
    Phenotypes 13
  • Earliest
    J:46962 Ishihara H, et al., Type I phosphatidylinositol-4-phosphate 5-kinases. Cloning of the third isoform and deletion/ substitution analysis of members of this novel lipid kinase family. J Biol Chem. 1998 Apr 10;273(15):8741-8
  • Latest
    J:333111 Triscott J, et al., PI5P4Kalpha supports prostate cancer metabolism and exposes a survival vulnerability during androgen receptor inhibition. Sci Adv. 2023 Feb 3;9(5):eade8641
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory