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Hcn4 Gene Detail
Summary
  • Symbol
    Hcn4
  • Name
    hyperpolarization-activated, cyclic nucleotide-gated K+ 4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1298209
    NCBI Gene: 330953
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:58730695-58770458 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 31.80 cM, cytoband C
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    949 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1298209
 protein coding gene Chr9:58730232-58770458 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034895
 protein coding gene Chr9:58128589-58167358 (+)
A/J MGP_AJ_G0034876
 protein coding gene Chr9:56243474-56280997 (+)
AKR/J MGP_AKRJ_G0034805
 protein coding gene Chr9:57544027-57581565 (+)
BALB/cJ MGP_BALBcJ_G0034868
 protein coding gene Chr9:56012344-56050053 (+)
C3H/HeJ MGP_C3HHeJ_G0034578
 protein coding gene Chr9:58040653-58078019 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035387
 protein coding gene Chr9:59748430-59787706 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032298
 protein coding gene Chr9:55512159-55549693 (+)
CAST/EiJ MGP_CASTEiJ_G0033899
 protein coding gene Chr9:58126295-58170285 (+)
CBA/J MGP_CBAJ_G0034549
 protein coding gene Chr9:61837036-61876466 (+)
DBA/2J MGP_DBA2J_G0034708
 protein coding gene Chr9:56090349-56128108 (+)
FVB/NJ MGP_FVBNJ_G0034650
 protein coding gene Chr9:55331706-55372454 (+)
LP/J MGP_LPJ_G0034791
 protein coding gene Chr9:58411532-58450031 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034693
 protein coding gene Chr9:63263898-63301994 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035409
 protein coding gene Chr9:57557766-57596246 (+)
PWK/PhJ MGP_PWKPhJ_G0033603
 protein coding gene Chr9:56152971-56214584 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033438
 protein coding gene Chr9:57844425-57887877 (+)
WSB/EiJ MGP_WSBEiJ_G0034012
 protein coding gene Chr9:57509601-57547724 (+)



Homology
more
  • Human Ortholog
    HCN4, hyperpolarization activated cyclic nucleotide gated potassium channel 4
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HCN4, hyperpolarization activated cyclic nucleotide gated potassium channel 4
  • Synonyms
    BRGDA8, EIG18, SSS2
  • Links
    NCBI Gene ID: 10021
    neXtProt AC: NX_Q9Y3Q4
    UniProt: Q9Y3Q4

  • Chr Location
    15q24.1; chr15:73319859-73368958 (-)  GRCh38
Human Diseases
more
  • Diseases
    4 with human HCN4 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 8 alleles in 7 genetic backgrounds
    10 phenotypes from multigenic genotypes
    35 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene experience embryonic lethality between E9.5 and E11.5. Conditional deletion in cardiac tissue results in severe bradycardia and death. Mice over-expressing the gene exhibit impaired firing rate in ORN, small olfactory bulb and reduced glomeruli.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    49
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    988
  • Tissues
    108
  • cDNA Data
    13
  • Literature Summary
    99
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000032338 Ensembl Gene Model | MGI Sequence Detail 39764 C57BL/6J ±  kb
    transcript ENSMUST00000034889 Ensembl | MGI Sequence Detail 6118 Not Applicable  
    polypeptide ENSMUSP00000034889 Ensembl | MGI Sequence Detail 1201 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000000708 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
      (term hierarchy)
    • InterPro Domains
      IPR018488 Cyclic nucleotide-binding, conserved site
      IPR000595 Cyclic nucleotide-binding domain
      IPR018490 Cyclic nucleotide-binding domain superfamily
      IPR005821 Ion transport domain
      IPR013621 Ion transport N-terminal
      IPR003938 Potassium channel, voltage-dependent, EAG/ELK/ERG
      IPR051413 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel
      IPR014710 RmlC-like jelly roll fold
    • GlyGen
      O70507 3 sites, 1 O-linked glycan (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 25
      cDNA 14
      Primer pair 6
      Other 5

      Microarray probesets 1
    References
    more
    • Summaries
      All 170
      Developmental Gene Expression 99
      Diseases 1
      Gene Ontology 10
      Phenotypes 35
    • Earliest
      J:45084 Santoro B, et al., Interactive cloning with the SH3 domain of N-src identifies a new brain specific ion channel protein, with homology to eag and cyclic nucleotide-gated channels. Proc Natl Acad Sci U S A. 1997 Dec 23;94(26):14815-20
    • Latest
      J:355648 Abassah-Oppong S, et al., A gene desert required for regulatory control of pleiotropic Shox2 expression and embryonic survival. Nat Commun. 2024 Oct 10;15(1):8793
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory