Hcn2 MGI Mouse Gene Detail - MGI:1298210 - hyperpolarization-activated, cyclic nucleotide-gated K+ 2

Symbol

Hcn2
Name

hyperpolarization-activated, cyclic nucleotide-gated K+ 2
Synonyms

HAC1, trls

Feature Type

protein coding gene
IDs

MGI:1298210
NCBI Gene: 15166
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr10:79552468-79571942 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 39.72 cM, cytoband C1
Mapping Data

2 experiments

SNPs within 2kb

389 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1298210	protein coding gene	Chr10:79552468-79571942 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017455	protein coding gene	Chr10:80258824-80278257 (+)
A/J	MGP_AJ_G0017433	protein coding gene	Chr10:77469400-77489767 (+)
AKR/J	MGP_AKRJ_G0017394	protein coding gene	Chr10:79575199-79596168 (+)
BALB/cJ	MGP_BALBcJ_G0017395	protein coding gene	Chr10:77696054-77715493 (+)
C3H/HeJ	MGP_C3HHeJ_G0017218	protein coding gene	Chr10:79683598-79703053 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017849	protein coding gene	Chr10:83033696-83053165 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015537	protein coding gene	Chr10:73695720-73714921 (+)
CAST/EiJ	MGP_CASTEiJ_G0016785	protein coding gene	Chr10:79856615-79877295 (+)
CBA/J	MGP_CBAJ_G0017190	protein coding gene	Chr10:86255441-86277170 (+)
DBA/2J	MGP_DBA2J_G0017296	protein coding gene	Chr10:76685215-76704666 (+)
FVB/NJ	MGP_FVBNJ_G0017290	protein coding gene	Chr10:75847284-75868112 (+)
LP/J	MGP_LPJ_G0017367	protein coding gene	Chr10:80738235-80758620 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017316	protein coding gene	Chr10:88236562-88255955 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017890	protein coding gene	Chr10:79552306-79571823 (+)
PWK/PhJ	MGP_PWKPhJ_G0016566	protein coding gene	Chr10:76542662-76562521 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016355	protein coding gene	Chr10:78526316-78545582 (+)
WSB/EiJ	MGP_WSBEiJ_G0016845	protein coding gene	Chr10:79584885-79604329 (+)

Human Ortholog

HCN2, hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

HCN2, hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2
Synonyms

BCNG-2, BCNG2, EIG17, FEB2, GEFSP11, HAC-1
Links

HGNC:4846

NCBI Gene ID: 610

neXtProt AC: NX_Q9UL51

UniProt: Q9UL51
Chr Location

19p13.3; chr19:589881-617159 (+) GRCh38

MGI Vertebrate Homology

Hcn2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: HCN2
Gene Tree

Hcn2

Diseases

1 with human HCN2 associations

				Human Disease	Mouse Models
				familial febrile seizures 2 IDs familial febrile seizures 2 DOID:0111310 OMIM:602477

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

41 phenotypes from 11 alleles in 11 genetic backgrounds
32 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

19
Chemically induced (ENU)

4
Chemically induced (other)

1
Endonuclease-mediated

5
Spontaneous

3
Targeted

6
Genomic Mutations

1 involving Hcn2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

31 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for mutant alleles exhibit decreased body weight, behavioral/neurological abnormalities, and tremors or absence seizures.

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All GO Annotations

47
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

799
Tissues

46
cDNA Data

14
Literature Summary

12

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase hcn2

ZFIN hcn2b

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All Sequences

31
RefSeq

2
UniProt

2
CCDS

CCDS23986.1

Ensembl

ENSMUSG00000020331 (Evidence)
NCBI Gene

15166

			Length	Strain/Species	Flank
genomic	15166	NCBI Gene Model \| MGI Sequence Detail	19475	C57BL/6J	± kb
transcript	NM_008226	RefSeq \| MGI Sequence Detail	3195	Not Specified
polypeptide	O88703	UniProt \| EBI \| MGI Sequence Detail	863	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000000706 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2

(term hierarchy)
PDB

1Q3E, 1Q43, 1Q5O, 2Q0A, 3BPZ, 3ETQ, 3FFQ, 4EQF, 5JON, 5KHG, 5KHH, 5KHI, 5KHJ, 5KHK
InterPro Domains

IPR018488 Cyclic nucleotide-binding, conserved site

IPR000595 Cyclic nucleotide-binding domain

IPR018490 Cyclic nucleotide-binding domain superfamily

IPR005821 Ion transport domain

IPR013621 Ion transport N-terminal

IPR003938 Potassium channel, voltage-dependent, EAG/ELK/ERG

IPR051413 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel

IPR014710 RmlC-like jelly roll fold
GlyGen

O88703 3 sites, 1 O-linked glycan (2 sites)

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All nucleic 20

cDNA 14

Primer pair 6

Microarray probesets 5

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MGI:3582956

Summaries

All 99

Developmental Gene Expression 12

Gene Ontology 10

Phenotypes 32
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:354124 Han X, et al., Opioid-Induced Hyperalgesia and Tolerance Are Driven by HCN Ion Channels. J Neurosci. 2024 Feb 7;44(6)

TSS for Hcn2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr94384	Chr10:79552422-79552500 (+)	-7 bp
Tssr94385	Chr10:79564584-79564606 (+)	12,127 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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