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Crygs Gene Detail
Summary
  • Symbol
    Crygs
  • Name
    crystallin, gamma S
  • Synonyms
    Opj
  • Feature Type
    protein coding gene
  • IDs
    MGI:1298216
    NCBI Gene: 12970
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:22623953-22630160 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 13.66 cM
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    335 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1298216
 protein coding gene Chr16:22623953-22630327 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022671
 protein coding gene Chr16:20325205-20331442 (-)
A/J MGP_AJ_G0022632
 protein coding gene Chr16:19344744-19350956 (-)
AKR/J MGP_AKRJ_G0022607
 protein coding gene Chr16:20156387-20162598 (-)
BALB/cJ MGP_BALBcJ_G0022637
 protein coding gene Chr16:19546684-19552894 (-)
C3H/HeJ MGP_C3HHeJ_G0022401
 protein coding gene Chr16:20257161-20263367 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023087
 protein coding gene Chr16:20768025-20774230 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020605
 protein coding gene Chr16:20037404-20043351 (-)
CAST/EiJ MGP_CASTEiJ_G0021931
 protein coding gene Chr16:20261529-20267755 (-)
CBA/J MGP_CBAJ_G0022373
 protein coding gene Chr16:21640894-21647091 (-)
DBA/2J MGP_DBA2J_G0022505
 protein coding gene Chr16:19325308-19331879 (-)
FVB/NJ MGP_FVBNJ_G0022481
 protein coding gene Chr16:19295229-19301705 (-)
LP/J MGP_LPJ_G0022573
 protein coding gene Chr16:20082810-20089326 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022500
 protein coding gene Chr16:21183756-21191430 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023098
 protein coding gene Chr16:20103211-20110313 (-)
PWK/PhJ MGP_PWKPhJ_G0021671
 protein coding gene Chr16:19570305-19576483 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021501
 protein coding gene Chr16:19888726-19894902 (-)
WSB/EiJ MGP_WSBEiJ_G0021974
 protein coding gene Chr16:20066564-20072766 (-)



Homology
more
  • Human Ortholog
    CRYGS, crystallin gamma S
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CRYGS, crystallin gamma S
  • Synonyms
    CRYG8, CTRCT20
  • Links
    NCBI Gene ID: 1427
    neXtProt AC: NX_P22914
    UniProt: P22914

  • Chr Location
    3q27.3; chr3:186538441-186546702 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Crygs mouse models; 1 with human CRYGS associations

Human Disease Mouse Models
      
IDs
 View 3 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 4 alleles in 4 genetic backgrounds
    1 phenotype from multigenic genotypes
    3 images
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mutations in this gene can cause cataracts and/or disrupted lens fiber cell morphology and organization. Aging mice homozygous for a knock-out allele do not develop cataracts but show focusing defects associated with inefficient clearance of cellular organelles and altered actin distribution.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    6
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    713
  • Tissues
    7
  • cDNA Data
    14
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12970 NCBI Gene Model | MGI Sequence Detail 6208 C57BL/6J ±  kb
    transcript NM_009967 RefSeq | MGI Sequence Detail 708 ZRU/MplStud  
    polypeptide O35486 UniProt | EBI | MGI Sequence Detail 178 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 15
      Genomic 1
      cDNA 14

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-13035, MGI:1890491, MGI:2146420, MGI:97437
    References
    more
    • Summaries
      All 37
      Developmental Gene Expression 3
      Diseases 3
      Gene Ontology 4
      Phenotypes 14
    • Earliest
      J:21950 Favor J, A comparison of the dominant cataract and recessive specific-locus mutation rates induced by treatment of male mice with ethylnitrosourea. Mutat Res. 1983 Aug;110(2):367-82
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory