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Mcm6 Gene Detail
Summary
  • Symbol
    Mcm6
  • Name
    minichromosome maintenance complex component 6
  • Synonyms
    D1Wsu22e, Mcmd6
  • Feature Type
    protein coding gene
  • IDs
    MGI:1298227
    NCBI Gene: 17219
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:128259327-128287401 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 55.80 cM, cytoband E4
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1021 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1298227
 protein coding gene Chr1:128259312-128287442 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016429
 protein coding gene Chr1:131572374-131602006 (-)
A/J MGP_AJ_G0016412
 protein coding gene Chr1:126664482-126695336 (-)
AKR/J MGP_AKRJ_G0016377
 protein coding gene Chr1:130415113-130443033 (-)
BALB/cJ MGP_BALBcJ_G0016372
 protein coding gene Chr1:127041346-127071059 (-)
C3H/HeJ MGP_C3HHeJ_G0016198
 protein coding gene Chr1:130578301-130607332 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016833
 protein coding gene Chr1:136520209-136550619 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014546
 protein coding gene Chr1:120022633-120050741 (-)
CAST/EiJ MGP_CASTEiJ_G0015779
 protein coding gene Chr1:129563289-129593121 (-)
CBA/J MGP_CBAJ_G0016171
 protein coding gene Chr1:141125028-141156237 (-)
DBA/2J MGP_DBA2J_G0016277
 protein coding gene Chr1:125701812-125729864 (-)
FVB/NJ MGP_FVBNJ_G0016276
 protein coding gene Chr1:124419173-124447301 (-)
LP/J MGP_LPJ_G0016348
 protein coding gene Chr1:132920078-132950519 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016301
 protein coding gene Chr1:146969234-146997780 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016869
 protein coding gene Chr1:130194421-130223646 (-)
PWK/PhJ MGP_PWKPhJ_G0015565
 protein coding gene Chr1:124679293-124708185 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015353
 protein coding gene Chr1:129145026-129175443 (-)
WSB/EiJ MGP_WSBEiJ_G0015841
 protein coding gene Chr1:130152355-130182301 (-)



Homology
more
  • Human Ortholog
    MCM6, minichromosome maintenance complex component 6
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MCM6, minichromosome maintenance complex component 6
  • Synonyms
    MCG40308, Mis5, P105MCM
  • Links
    NCBI Gene ID: 4175
    neXtProt AC: NX_Q14566
    UniProt: Q14566

  • Chr Location
    2q21.3; chr2:135839626-135876443 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    7 phenotypes from multigenic genotypes
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trapped allele exhibit prenatal lethality. Mice heterozygous for this allele exhibit increased micronulei-containing red blood cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    50
  • GO References
    18
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    760
  • Tissues
    38
  • cDNA Data
    228
  • Literature Summary
    12
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000026355 Ensembl Gene Model | MGI Sequence Detail 28075 C57BL/6J ±  kb
transcript ENSMUST00000027601 Ensembl | MGI Sequence Detail 2910 Not Applicable  
polypeptide ENSMUSP00000027601 Ensembl | MGI Sequence Detail 821 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 232
    Genomic 2
    cDNA 229
    Primer pair 1

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-34267, MGI:106573
References
more
  • Summaries
    All 69
    Developmental Gene Expression 12
    Gene Ontology 18
    Phenotypes 11
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:313619 Bedogni F, et al., Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory