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Cabin1 Gene Detail
Summary
  • Symbol
    Cabin1
  • Name
    calcineurin binding protein 1
  • Synonyms
    A330070M20Rik, Cain, Ppp3in
  • Feature Type
    protein coding gene
  • IDs
    MGI:1298375
    NCBI Gene: 104248
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:75481946-75600175 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 38.56 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2400 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1298375
 protein coding gene Chr10:75481944-75600194 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017361
 protein coding gene Chr10:75826247-75948456 (-)
A/J MGP_AJ_G0017338
 protein coding gene Chr10:73224294-73343520 (-)
AKR/J MGP_AKRJ_G0017299
 protein coding gene Chr10:75186871-75304805 (-)
BALB/cJ MGP_BALBcJ_G0017298
 protein coding gene Chr10:73420008-73538995 (-)
C3H/HeJ MGP_C3HHeJ_G0017122
 protein coding gene Chr10:75225330-75346702 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017756
 protein coding gene Chr10:78514522-78635991 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015446
 protein coding gene Chr10:69682759-69798962 (-)
CAST/EiJ MGP_CASTEiJ_G0016693
 protein coding gene Chr10:75546767-75667120 (-)
CBA/J MGP_CBAJ_G0017094
 protein coding gene Chr10:81582234-81702862 (-)
DBA/2J MGP_DBA2J_G0017199
 protein coding gene Chr10:72527186-72645182 (-)
FVB/NJ MGP_FVBNJ_G0017192
 protein coding gene Chr10:71670775-71793369 (-)
LP/J MGP_LPJ_G0017272
 protein coding gene Chr10:76327084-76449708 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017220
 protein coding gene Chr10:83678990-83798110 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017795
 protein coding gene Chr10:75215574-75335112 (-)
PWK/PhJ MGP_PWKPhJ_G0016476
 protein coding gene Chr10:72352415-72470637 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016259
 protein coding gene Chr10:74462103-74581692 (-)
WSB/EiJ MGP_WSBEiJ_G0016756
 protein coding gene Chr10:75190708-75313610 (-)



Homology
more
  • Human Ortholog
    CABIN1, calcineurin binding protein 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CABIN1, calcineurin binding protein 1
  • Synonyms
    CAIN, KB-318B8.7, PPP3IN
  • Links
    NCBI Gene ID: 23523
    neXtProt AC: NX_Q9Y6J0
    UniProt: Q9Y6J0

  • Chr Location
    22q11.23; chr22:24011192-24178628 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human CABIN1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 3 alleles in 3 genetic backgrounds
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutants exhibit embryonic lethality during organogenesis. Mice producing a truncated protein exhibit elevated levels of serum IgG1, IgG2b and IgE, produce more IgG1 in response to T-cell dependent antigen, and have enhanced expression of cytokines in response to anti-CD3 stimulation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    708
  • Tissues
    2
  • cDNA Data
    20
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020196 Ensembl Gene Model | MGI Sequence Detail 118230 C57BL/6J ±  kb
    transcript ENSMUST00000001712 Ensembl | MGI Sequence Detail 7417 Not Applicable  
    polypeptide ENSMUSP00000001712 Ensembl | MGI Sequence Detail 2187 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      14 Sequences
    • InterPro Domains
      IPR015134 Calcineurin-binding protein cabin-1, MEF2-binding domain
      IPR033053 Histone transcription regulator 3/CABIN1
      IPR011990 Tetratricopeptide-like helical domain superfamily
      IPR019734 Tetratricopeptide repeat
    Molecular
    Reagents
    less
    • All nucleic 28
      Genomic 7
      cDNA 20
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1351873, MGI:2442407
    References
    more
    • Summaries
      All 48
      Developmental Gene Expression 2
      Gene Ontology 4
      Phenotypes 20
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    11/12/2024
    MGI 6.24     		The Jackson Laboratory