Itgae MGI Mouse Gene Detail - MGI:1298377 - integrin alpha E, epithelial-associated

Symbol

Itgae
Name

integrin alpha E, epithelial-associated
Synonyms

alpha-E1, CD103

Feature Type

protein coding gene
IDs

MGI:1298377
NCBI Gene: 16407
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr11:72981409-73038272 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 45.22 cM
Mapping Data

3 experiments

SNPs within 2kb

532 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1298377	protein coding gene	Chr11:72981396-73038272 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018651	protein coding gene	Chr11:73761403-73825042 (+)
A/J	MGP_AJ_G0018619	protein coding gene	Chr11:70991750-71054064 (+)
AKR/J	MGP_AKRJ_G0018588	protein coding gene	Chr11:73158093-73221536 (+)
BALB/cJ	MGP_BALBcJ_G0018591	protein coding gene	Chr11:71296253-71355332 (+)
C3H/HeJ	MGP_C3HHeJ_G0018404	protein coding gene	Chr11:73115705-73177203 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019042	protein coding gene	Chr11:75991727-76074245 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016685	protein coding gene	Chr11:67801996-67860045 (+)
CAST/EiJ	MGP_CASTEiJ_G0017959	protein coding gene	Chr11:73496843-73558952 (+)
CBA/J	MGP_CBAJ_G0018376	protein coding gene	Chr11:79360793-79423117 (+)
DBA/2J	MGP_DBA2J_G0018485	protein coding gene	Chr11:70621878-70678522 (+)
FVB/NJ	MGP_FVBNJ_G0018476	protein coding gene	Chr11:70168162-70228378 (+)
LP/J	MGP_LPJ_G0018556	protein coding gene	Chr11:74259065-74321422 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018499	protein coding gene	Chr11:79876530-79937504 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019084	protein coding gene	Chr11:73348693-73407212 (+)
PWK/PhJ	MGP_PWKPhJ_G0017732	protein coding gene	Chr11:71258865-71320150 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017522	protein coding gene	Chr11:73061239-73125002 (+)
WSB/EiJ	MGP_WSBEiJ_G0018013	protein coding gene	Chr11:73096262-73154406 (+)

Human Ortholog

ITGAE, integrin subunit alpha E

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ITGAE, integrin subunit alpha E
Synonyms

CD103, HUMINAE
Links

HGNC:6147

NCBI Gene ID: 3682

neXtProt AC: NX_P38570

UniProt: P38570
Chr Location

17p13.2; chr17:3714628-3801188 (-) GRCh38

MGI Vertebrate Homology

Itgae stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: ITGAE
Gene Tree

Itgae

less

Phenotype Summary

7 phenotypes from 2 alleles in 2 genetic backgrounds
62 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

46
Chemically induced (other)

1
Endonuclease-mediated

5
Gene trapped

32
Targeted

8
Genomic Mutations

2 involving Itgae
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

83 strains or lines available

Homozygotes for a targeted null mutation exhibit reductions in the numbers of intestinal and vaginal intraepithelial lymphocytes and of T lymphocytes of the lamina propria.

less

All GO Annotations

13
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

721
Tissues

15
cDNA Data

20
Literature Summary

6

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase itgae

less

All Sequences

47
RefSeq

8
UniProt

5
CCDS

CCDS24995.1, CCDS24996.1

Ensembl

ENSMUSG00000005947 (Evidence)
NCBI Gene

16407

			Length	Strain/Species	Flank
genomic	ENSMUSG00000005947	Ensembl Gene Model \| MGI Sequence Detail	56864	C57BL/6J	± kb
transcript	ENSMUST00000006101	Ensembl \| MGI Sequence Detail	3845	Not Applicable
polypeptide	ENSMUSP00000006101	Ensembl \| MGI Sequence Detail	1167	Not Applicable

less

UniProt

5 Sequences
Protein Ontology

PR:000001010 integrin alpha-E

(term hierarchy)
InterPro Domains

IPR013517 FG-GAP repeat

IPR013519 Integrin alpha beta-propellor

IPR000413 Integrin alpha chain

IPR018184 Integrin alpha chain, C-terminal cytoplasmic region, conserved site

IPR028994 Integrin alpha, N-terminal

IPR048285 Integrin alpha, second immunoglobulin-like domain

IPR032695 Integrin domain superfamily

IPR036465 von Willebrand factor A-like domain superfamily

IPR002035 von Willebrand factor, type A
GlyGen

Q60677 18 sites, 1 O-linked glycan (1 site)

less

All nucleic 21

cDNA 20

Primer pair 1

Microarray probesets 5

Summaries

All 131

Developmental Gene Expression 6

Gene Ontology 8

Phenotypes 62
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:354883 Burton OT, et al., The tissue-resident regulatory T cell pool is shaped by transient multi-tissue migration and a conserved residency program. Immunity. 2024 Jul 9;57(7):1586-1602.e10

TSS for Itgae:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr102877	Chr11:72981380-72981429 (+)	-4 bp
Tssr102878	Chr11:73002573-73002616 (+)	21,186 bp
Tssr102879	Chr11:73017580-73017603 (+)	36,183 bp
Tssr102880	Chr11:73029113-73029116 (+)	47,706 bp
Tssr102881	Chr11:73029139-73029182 (+)	47,752 bp
Tssr102882	Chr11:73029184-73029198 (+)	47,782 bp
Tssr102883	Chr11:73029265-73029308 (+)	47,878 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24