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Clec4d Gene Detail
Summary
  • Symbol
    Clec4d
  • Name
    C-type lectin domain family 4, member d
  • Synonyms
    Clecsf8, mcl, mMCL, Mpcl
  • Feature Type
    protein coding gene
  • IDs
    MGI:1298389
    NCBI Gene: 17474
  • Alliance
    gene page
  • Transcription Start Sites
    37 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:123239070-123252224 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 58.33 cM, cytoband F3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    517 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1298389
 protein coding gene Chr6:123239066-123252227 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031243
 protein coding gene Chr6:126414584-126427757 (+)
A/J MGP_AJ_G0031212
 protein coding gene Chr6:121577041-121590191 (+)
AKR/J MGP_AKRJ_G0031142
 protein coding gene Chr6:124954720-124967866 (+)
BALB/cJ MGP_BALBcJ_G0031222
 protein coding gene Chr6:121305765-121318915 (+)
C3H/HeJ MGP_C3HHeJ_G0030941
 protein coding gene Chr6:124913504-124926646 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031681
 protein coding gene Chr6:129742725-129755879 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028837
 protein coding gene Chr6:118144435-118157712 (+)
CAST/EiJ MGP_CASTEiJ_G0030330
 protein coding gene Chr6:125165665-125178761 (+)
CBA/J MGP_CBAJ_G0030904
 protein coding gene Chr6:134821223-134834367 (+)
DBA/2J MGP_DBA2J_G0031060
 protein coding gene Chr6:120539652-120552798 (+)
FVB/NJ MGP_FVBNJ_G0031012
 protein coding gene Chr6:119465582-119478745 (+)
LP/J MGP_LPJ_G0031141
 protein coding gene Chr6:126588140-126601329 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031048
 protein coding gene Chr6:138745951-138759096 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031710
 protein coding gene Chr6:124855789-124868935 (+)
PWK/PhJ MGP_PWKPhJ_G0030044
 protein coding gene Chr6:119358848-119372148 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029872
 protein coding gene Chr6:122992641-123007063 (+)
WSB/EiJ MGP_WSBEiJ_G0030412
 protein coding gene Chr6:125148302-125161814 (+)



Homology
more
  • Human Ortholog
    CLEC4D, C-type lectin domain family 4 member D
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CLEC4D, C-type lectin domain family 4 member D
  • Synonyms
    CD368, CLEC-6, CLEC6, CLECSF8, Dectin-3, MCL, MPCL
  • Links
    NCBI Gene ID: 338339
    neXtProt AC: NX_Q8WXI8
    UniProt: Q8WXI8

  • Chr Location
    12p13.31; chr12:8509475-8531696 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    31 phenotypes from 2 alleles in 2 genetic backgrounds
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased sensitivity to trehalose-6,60'-dimycolate treatment. Mice homozygous for a different knock-out allele exhibit increased susceptibility to pneumonia infection.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    719
  • Tissues
    13
  • cDNA Data
    14
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000030144 Ensembl Gene Model | MGI Sequence Detail 13155 C57BL/6J ±  kb
    transcript ENSMUST00000032240 Ensembl | MGI Sequence Detail 1323 Not Applicable  
    polypeptide ENSMUSP00000032240 Ensembl | MGI Sequence Detail 219 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 15
      Genomic 1
      cDNA 14

      Microarray probesets 3
    References
    more
    • Summaries
      All 55
      Developmental Gene Expression 1
      Gene Ontology 6
      Phenotypes 26
    • Earliest
      J:48677 Balch SG, et al., Cloning of a novel C-type lectin expressed by murine macrophages. J Biol Chem. 1998 Jul 17;273(29):18656-64
    • Latest
      J:344288 Muraosa Y, et al., Fungal chitin-binding glycoprotein induces Dectin-2-mediated allergic airway inflammation synergistically with chitin. PLoS Pathog. 2024 Jan;20(1):e1011878
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory