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Map1b Gene Detail
Summary
  • Symbol
    Map1b
  • Name
    microtubule-associated protein 1B
  • Synonyms
    LC1, MAP5, Mtap1b, Mtap-5, Mtap5
  • Feature Type
    protein coding gene
  • IDs
    MGI:1306778
    NCBI Gene: 17755
  • Alliance
    gene page
  • Transcription Start Sites
    81 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:99557954-99653048 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 52.90 cM
  • Mapping Data
    18 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2452 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    2
  • RFLP
    6
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1306778
 protein coding gene Chr13:99557954-99653110 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020876
 protein coding gene Chr13:101209191-101306976 (-)
A/J MGP_AJ_G0020830
 protein coding gene Chr13:97327192-97423884 (-)
AKR/J MGP_AKRJ_G0020804
 protein coding gene Chr13:100304299-100403899 (-)
BALB/cJ MGP_BALBcJ_G0020828
 protein coding gene Chr13:98031013-98128734 (-)
C3H/HeJ MGP_C3HHeJ_G0020619
 protein coding gene Chr13:100036702-100134111 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021262
 protein coding gene Chr13:104223873-104337207 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018831
 protein coding gene Chr13:93065293-93159278 (-)
CAST/EiJ MGP_CASTEiJ_G0020137
 protein coding gene Chr13:99448267-99546355 (-)
CBA/J MGP_CBAJ_G0020579
 protein coding gene Chr13:108357138-108457104 (-)
DBA/2J MGP_DBA2J_G0020704
 protein coding gene Chr13:97096649-97196386 (-)
FVB/NJ MGP_FVBNJ_G0020685
 protein coding gene Chr13:95841900-95937614 (-)
LP/J MGP_LPJ_G0020779
 protein coding gene Chr13:101305049-101408332 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020713
 protein coding gene Chr13:108662827-108759771 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021303
 protein coding gene Chr13:99751066-99850943 (-)
PWK/PhJ MGP_PWKPhJ_G0019890
 protein coding gene Chr13:95917009-96013754 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019713
 protein coding gene Chr13:96046519-96143209 (-)
WSB/EiJ MGP_WSBEiJ_G0020195
 protein coding gene Chr13:100191981-100293084 (-)



Homology
more
  • Human Ortholog
    MAP1B, microtubule associated protein 1B
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MAP1B, microtubule associated protein 1B
  • Synonyms
    DFNA83, FUTSCH, MAP5, PPP1R102, PVNH9
  • Links
    NCBI Gene ID: 4131
    neXtProt AC: NX_P46821
    UniProt: P46821

  • Chr Location
    5q13.2; chr5:72107234-72209565 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human MAP1B associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    48 phenotypes from 3 alleles in 5 genetic backgrounds
    12 phenotypes from multigenic genotypes
    35 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for one knock-out allele die prior to E8.5. While mice homozygous for other knock-out alleles exhibit behavioral, visual system, and nervous system defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    95
  • GO References
    18
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1014
  • Tissues
    96
  • cDNA Data
    37
  • Literature Summary
    29
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000052727 Ensembl Gene Model | MGI Sequence Detail 95095 C57BL/6J ±  kb
    transcript ENSMUST00000064762 Ensembl | MGI Sequence Detail 11808 Not Applicable  
    polypeptide ENSMUSP00000068374 Ensembl | MGI Sequence Detail 2464 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 57
      Genomic 4
      cDNA 41
      Primer pair 10
      Other 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-12583, MGD-MRK-12589, MGI:2145294, MGI:97179
    References
    more
    • Summaries
      All 126
      Developmental Gene Expression 29
      Gene Ontology 18
      Phenotypes 35
    • Earliest
      J:34302 Noble M, et al., The microtubule binding domain of microtubule-associated protein MAP1B contains a repeated sequence motif unrelated to that of MAP2 and tau. J Cell Biol. 1989 Dec;109(6 Pt 2):3367-76
    • Latest
      J:345844 Guo Y, et al., Docking protein 6 (DOK6) selectively docks the neurotrophic signaling transduction to restrain peripheral neuropathy. Signal Transduct Target Ther. 2024 Feb 14;9(1):32
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory