Dio3 MGI Mouse Gene Detail - MGI:1306782 - deiodinase, iodothyronine type III

Symbol

Dio3
Name

deiodinase, iodothyronine type III

Feature Type

protein coding gene
IDs

MGI:1306782
NCBI Gene: 107585
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr12:110245664-110247531 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 60.56 cM, cytoband F1
Mapping Data

2 experiments

SNPs within 2kb

87 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1306782	protein coding gene	Chr12:110245502-110247531 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0020116	protein coding gene	Chr12:112560353-112562382 (+)
A/J	MGP_AJ_G0020070	protein coding gene	Chr12:108206440-108208469 (+)
AKR/J	MGP_AKRJ_G0020046	protein coding gene	Chr12:111374765-111376793 (+)
BALB/cJ	MGP_BALBcJ_G0020056	protein coding gene	Chr12:108683646-108685675 (+)
C3H/HeJ	MGP_C3HHeJ_G0019858	protein coding gene	Chr12:111819610-111821639 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020501	protein coding gene	Chr12:116001616-116003645 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018113	protein coding gene	Chr12:104710790-104712821 (+)
CAST/EiJ	MGP_CASTEiJ_G0019400	protein coding gene	Chr12:106771962-106773991 (+)
CBA/J	MGP_CBAJ_G0019825	protein coding gene	Chr12:120511813-120513842 (+)
DBA/2J	MGP_DBA2J_G0019942	protein coding gene	Chr12:107752375-107754403 (+)
FVB/NJ	MGP_FVBNJ_G0019927	protein coding gene	Chr12:106553736-106555765 (+)
LP/J	MGP_LPJ_G0020017	protein coding gene	Chr12:112394732-112396761 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019965	protein coding gene	Chr12:123667136-123669164 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020530	protein coding gene	Chr12:110851274-110853303 (+)
PWK/PhJ	MGP_PWKPhJ_G0019159	protein coding gene	Chr12:102367046-102369075 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018963	protein coding gene	Chr12:105018042-105020072 (+)
WSB/EiJ	MGP_WSBEiJ_G0019457	protein coding gene	Chr12:111764960-111766989 (+)

Human Ortholog

DIO3, iodothyronine deiodinase 3

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DIO3, iodothyronine deiodinase 3
Synonyms

5DIII, D3, DIOIII, TXDI3
Links

HGNC:2885

NCBI Gene ID: 1735

neXtProt AC: NX_P55073

UniProt: P55073
Chr Location

14q32.31; chr14:101560139-101563452 (+) GRCh38

MGI Vertebrate Homology

Dio3 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: DIO3
Protein SuperFamily

IOD
Gene Tree

Dio3

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Phenotype Summary

19 phenotypes from 2 alleles in 2 genetic backgrounds
30 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Endonuclease-mediated

2
Targeted

4
Incidental Mutations

APF
Find Mice (IMSR)

7 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele show partial embryonic or perinatal mortality, growth retardation, reduced fertility, and severe anomalies in thyroid status and physiology, including reduced T3 clearance and neonatal thyrotoxicosis followed by central hypothyroidism that persists throughout life.

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All GO Annotations

19
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1014
Tissues

169
cDNA Data

10
Literature Summary

42

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA DIO3

Xenbase dio3

ZFIN dio3a, dio3b

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All Sequences

36
RefSeq

2
UniProt

2
CCDS

CCDS26171.2

Ensembl

ENSMUSG00000075707 (Evidence)
NCBI Gene

107585

			Length	Strain/Species	Flank
genomic	107585	NCBI Gene Model \| MGI Sequence Detail	1868	C57BL/6J	± kb
transcript	NM_172119	RefSeq \| MGI Sequence Detail	1872	C57BL/6
polypeptide	Q91ZI8	UniProt \| EBI \| MGI Sequence Detail	304	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000006482 thyroxine 5-deiodinase

(term hierarchy)
PDB

4TR3, 4TR4
EC

1.21.99.3
InterPro Domains

IPR000643 Iodothyronine deiodinase

IPR008261 Iodothyronine deiodinase, active site

IPR027252 Iodothyronine deiodinase I/III

IPR036249 Thioredoxin-like superfamily

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All nucleic 27

Genomic 3

cDNA 11

Primer pair 11

Other 2

Microarray probesets 1

Summaries

All 105

Developmental Gene Expression 42

Gene Ontology 10

Phenotypes 30
Earliest

J:50456 Hernandez A, et al., Localization of the type 3 iodothyronine deiodinase (DIO3) gene to human chromosome 14q32 and mouse chromosome 12F1. Genomics. 1998 Oct 1;53(1):119-21
Latest

J:357738 Liu Y, et al., Cone photoreceptor differentiation regulated by thyroid hormone transporter MCT8 in the retinal pigment epithelium. Proc Natl Acad Sci U S A. 2024 Jul 23;121(30):e2402560121

TSS for Dio3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr115195	Chr12:110245662-110245665 (+)	0 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24