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Ugdh Gene Detail
Summary
  • Symbol
    Ugdh
  • Name
    UDP-glucose dehydrogenase
  • Synonyms
    Udpgdh
  • Feature Type
    protein coding gene
  • IDs
    MGI:1306785
    NCBI Gene: 22235
  • Alliance
    gene page
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:65570550-65593185 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 33.67 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    713 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1306785
 protein coding gene Chr5:65570550-65593292 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029578
 protein coding gene Chr5:65047790-65073112 (-)
A/J MGP_AJ_G0029546
 protein coding gene Chr5:62632868-62656650 (-)
AKR/J MGP_AKRJ_G0029494
 protein coding gene Chr5:64625039-64649880 (-)
BALB/cJ MGP_BALBcJ_G0029555
 protein coding gene Chr5:63323248-63346424 (-)
C3H/HeJ MGP_C3HHeJ_G0029278
 protein coding gene Chr5:64964030-64988385 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030009
 protein coding gene Chr5:67728600-67753634 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027249
 protein coding gene Chr5:58706940-58728989 (-)
CAST/EiJ MGP_CASTEiJ_G0028686
 protein coding gene Chr5:64067481-64089959 (-)
CBA/J MGP_CBAJ_G0029247
 protein coding gene Chr5:69928459-69955151 (-)
DBA/2J MGP_DBA2J_G0029393
 protein coding gene Chr5:62671364-62693815 (-)
FVB/NJ MGP_FVBNJ_G0029353
 protein coding gene Chr5:61843196-61866139 (-)
LP/J MGP_LPJ_G0029478
 protein coding gene Chr5:65555418-65580653 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029381
 protein coding gene Chr5:72811144-72834381 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030042
 protein coding gene Chr5:64295961-64318960 (-)
PWK/PhJ MGP_PWKPhJ_G0028410
 protein coding gene Chr5:61635613-61658540 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028244
 protein coding gene Chr5:63612227-63634450 (-)
WSB/EiJ MGP_WSBEiJ_G0028766
 protein coding gene Chr5:64498703-64521184 (-)



Homology
more
  • Human Ortholog
    UGDH, UDP-glucose 6-dehydrogenase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    UGDH, UDP-glucose 6-dehydrogenase
  • Synonyms
    DEE84, EIEE84, GDH, UDPGDH, UDP-GlcDH, UGD
  • Links
    NCBI Gene ID: 7358
    neXtProt AC: NX_O60701
    UniProt: O60701

  • Chr Location
    4p14; chr4:39498755-39528311 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human UGDH associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    14 phenotypes from 2 alleles in 4 genetic backgrounds
    3 phenotypes from multigenic genotypes
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mutation of this gene results in developmental arrest during gastrulation with defects in endoderm and mesoderm migration.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    24
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    815
  • Tissues
    105
  • cDNA Data
    105
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 22235 NCBI Gene Model | MGI Sequence Detail 22636 C57BL/6J ±  kb
    transcript NM_009466 RefSeq | MGI Sequence Detail 2461 FVB/N  
    polypeptide O70475 UniProt | EBI | MGI Sequence Detail 493 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • Protein Ontology
      PR:000017046 UDP-glucose 6-dehydrogenase
      (term hierarchy)
    • EC
      1.1.1.22
    • InterPro Domains
      IPR008927 6-phosphogluconate dehydrogenase-like, C-terminal domain superfamily
      IPR036291 NAD(P)-binding domain superfamily
      IPR028356 UDP-glucose 6-dehydrogenase, eukaryotic type
      IPR017476 UDP-glucose/GDP-mannose dehydrogenase
      IPR014027 UDP-glucose/GDP-mannose dehydrogenase, C-terminal
      IPR036220 UDP-glucose/GDP-mannose dehydrogenase, C-terminal domain superfamily
      IPR014026 UDP-glucose/GDP-mannose dehydrogenase, dimerisation
      IPR001732 UDP-glucose/GDP-mannose dehydrogenase, N-terminal
    • GlyGen
      O70475 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 109
      Genomic 1
      cDNA 106
      Primer pair 1
      Other 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 62
      Developmental Gene Expression 7
      Gene Ontology 12
      Phenotypes 28
    • Earliest
      J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
    • Latest
      J:345473 Lee JG, et al., PIBF1 regulates trophoblast syncytialization and promotes cardiovascular development. Nat Commun. 2024 Feb 19;15(1):1487
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory