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Pakap Gene Detail
Summary
  • Symbol
    Pakap
  • Name
    paralemmin A kinase anchor protein
  • Synonyms
    53-H12, AF064781, Akap2, AKAP-KL, B230340M18Rik, Gm20459, Palm2, Palm2-Akap2, Palm2Akap2, pEN70
  • Feature Type
    protein coding gene
  • IDs
    MGI:5141924
    NCBI Gene: 677884
  • Alliance
    gene page
  • Transcription Start Sites
    49 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:57434475-57896984 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 31.66 cM, cytoband C1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    13613 from dbSNP Build 142
  • Strain Annotations
    52
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_5141924
 protein coding gene Chr4:57434247-57896984 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028317
 protein coding gene Chr4:56229950-56523201 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028318
 protein coding gene Chr4:56377204-56708277 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028319
 protein coding gene Chr4:56528778-56708280 (+)
A/J MGP_AJ_G0028278
 protein coding gene Chr4:54221016-54365759 (+)
A/J MGP_AJ_G0028280
 protein coding gene Chr4:54374090-54554984 (+)
A/J MGP_AJ_G0028279
 protein coding gene Chr4:54221311-54554981 (+)
AKR/J MGP_AKRJ_G0028227
 protein coding gene Chr4:55579910-55869640 (+)
AKR/J MGP_AKRJ_G0028229
 protein coding gene Chr4:55877559-56060399 (+)
AKR/J MGP_AKRJ_G0028228
 protein coding gene Chr4:55720929-56060396 (+)
BALB/cJ MGP_BALBcJ_G0028297
 protein coding gene Chr4:54250460-54530769 (+)
BALB/cJ MGP_BALBcJ_G0028299
 protein coding gene Chr4:54536082-54716961 (+)
BALB/cJ MGP_BALBcJ_G0028298
 protein coding gene Chr4:54385554-54716958 (+)
C3H/HeJ MGP_C3HHeJ_G0028019
 protein coding gene Chr4:56232612-56569843 (+)
C3H/HeJ MGP_C3HHeJ_G0028018
 protein coding gene Chr4:56094109-56379823 (+)
C3H/HeJ MGP_C3HHeJ_G0028020
 protein coding gene Chr4:56384951-56569846 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028739
 protein coding gene Chr4:58375333-58739112 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028740
 protein coding gene Chr4:58541164-58734461 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028738
 protein coding gene Chr4:58235046-58532970 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026045
 protein coding gene Chr4:51010248-51332233 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026044
 protein coding gene Chr4:50879424-51152885 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026046
 protein coding gene Chr4:51158510-51332231 (+)
CAST/EiJ MGP_CASTEiJ_G0027456
 protein coding gene Chr4:55811132-56104529 (+)
CAST/EiJ MGP_CASTEiJ_G0027457
 protein coding gene Chr4:55953075-56300926 (+)
CAST/EiJ MGP_CASTEiJ_G0027458
 protein coding gene Chr4:56112219-56300929 (+)
CBA/J MGP_CBAJ_G0027984
 protein coding gene Chr4:60395680-60729783 (+)
CBA/J MGP_CBAJ_G0027985
 protein coding gene Chr4:60550030-60729786 (+)
CBA/J MGP_CBAJ_G0027983
 protein coding gene Chr4:60244255-60544591 (+)
DBA/2J MGP_DBA2J_G0028135
 protein coding gene Chr4:54273915-54453051 (+)
DBA/2J MGP_DBA2J_G0028133
 protein coding gene Chr4:53990474-54267882 (+)
DBA/2J MGP_DBA2J_G0028134
 protein coding gene Chr4:54122845-54453048 (+)
FVB/NJ MGP_FVBNJ_G0028100
 protein coding gene Chr4:53218050-53497623 (+)
FVB/NJ MGP_FVBNJ_G0028102
 protein coding gene Chr4:53503556-53679576 (+)
FVB/NJ MGP_FVBNJ_G0028101
 protein coding gene Chr4:53351481-53679573 (+)
LP/J MGP_LPJ_G0028233
 protein coding gene Chr4:56476834-56822514 (+)
LP/J MGP_LPJ_G0028234
 protein coding gene Chr4:56632030-56822517 (+)
LP/J MGP_LPJ_G0028232
 protein coding gene Chr4:56476567-56623349 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028126
 protein coding gene Chr4:63674409-63865090 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028125
 protein coding gene Chr4:63519436-63865087 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028124
 protein coding gene Chr4:63519133-63670141 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028776
 protein coding gene Chr4:56073479-56265866 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028774
 protein coding gene Chr4:55768688-56067163 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028775
 protein coding gene Chr4:55917842-56265863 (+)
PWK/PhJ MGP_PWKPhJ_G0027182
 protein coding gene Chr4:54130572-54455786 (+)
PWK/PhJ MGP_PWKPhJ_G0027183
 protein coding gene Chr4:54273938-54455789 (+)
PWK/PhJ MGP_PWKPhJ_G0027181
 protein coding gene Chr4:53991545-54268217 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027010
 protein coding gene Chr4:55189601-55535837 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027011
 protein coding gene Chr4:55345859-55535835 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027009
 protein coding gene Chr4:55055905-55340247 (+)
WSB/EiJ MGP_WSBEiJ_G0027535
 protein coding gene Chr4:55858179-56215098 (+)
WSB/EiJ MGP_WSBEiJ_G0027536
 protein coding gene Chr4:56020081-56215101 (+)
WSB/EiJ MGP_WSBEiJ_G0027534
 protein coding gene Chr4:55721607-56012928 (+)



Homology
more
  • Human Ortholog
    PALM2AKAP2, PALM2 and AKAP2 fusion
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PALM2AKAP2, PALM2 and AKAP2 fusion
  • Synonyms
    AKAP-2, AKAP2, AKAP-KL, AKAPKL, MISP2, PALM2, PALM2-AKAP2, PRKA2
  • Links
    NCBI Gene ID: 445815
    neXtProt AC: NX_Q8IXS6, NX_Q9Y2D5
    UniProt: Q9Y2D5

  • Chr Location
    9q31.3; chr9:109498325-110172512 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for loss of expression in the heart display increased susceptibility to myocardial ischemic injury.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    11
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    68
  • Tissues
    23
  • cDNA Data
    28
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 677884 NCBI Gene Model | MGI Sequence Detail 462510 C57BL/6J ±  kb
    transcript NM_001384149 RefSeq | MGI Sequence Detail 8581 C57BL/6  
    polypeptide O54931 UniProt | EBI | MGI Sequence Detail 1089 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 31
      cDNA 29
      Primer pair 2

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGI:1306795, MGI:1934601, MGI:2140178, MGI:2140348, MGI:2140719, MGI:2443506, MGI:3845895
    References
    more
    • Summaries
      All 41
      Developmental Gene Expression 5
      Gene Ontology 6
      Phenotypes 4
    • Earliest
      J:46555 Dong F, et al., Molecular characterization of a cDNA that encodes six isoforms of a novel murine A kinase anchor protein. J Biol Chem. 1998 Mar 13;273(11):6533-41
    • Latest
      J:345193 Maric D, et al., A-Kinase Anchoring Protein 2 Promotes Protection against Myocardial Infarction. Cells. 2021 Oct 23;10(11)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory